The effects of local and sustained release of fibroblast growth factor on wound healing in esophageal anastomoses

Fedakar-Senyucel, Mine; Bingöl-Koloğlu, Meltem; Vargun, Rahsan; Akbay, Canan; Saraç, Fahriye; Renda, Nurten; Hasırcı, Nesrin; Göllü, Gülnur; Dindar, Hüseyin

doi:10.1016/j.jpedsurg.2007.10.016

Cited by 24 publications

(26 citation statements)

References 28 publications

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“…AI, CI, GTA, GTFM, CD, re-epithelialization (R), neovascularization (N), and PTR in anastomosis lines could be considered reliable and objective anastomoses markers in scar tissue formation. 7,9 Our results showed that the local application of NH significantly increased AI scores in the NH group when compared with the S group and significantly increased GTA in the NH group when compared with the S group. NH did not decrease fibrosis, but increased important parameters in wound healing such as re-epithelialization and neovascularization in an experimental model of PUA in rabbits.…”

Section: Discussionmentioning

confidence: 60%

“…Ab7778) antibodies were used for immunohistochemistry. [7][8][9][10][11][12] The specimens were scored for the differentiation of the healing and the repairing of the PUA. Histopathological parameters such as acute inflammation (AI) (presence of polymorphonuclear leukocytes at the anastomosis site), chronic inflammation (CI) (presence of lymphocytes and plasma cells), extent of granulation tissue (amount of granulation tissue), granulation tissue fibroblast maturation (maturation of granulation tissue, namely young, plump fibroblasts within a basophilic background or spindle fibroblasts compressed within a hyalinized background), collagen deposition (collagen matrix deposition between fibroblast bundles), re-epithelialization (urothelial re-epithelializationover the anastomosis site), neovascularization (amount of vascular proliferation during healing phase), and peripheral tissue reaction (PTR) (amount of foreign body reaction and reactive changes in the surrounding tissues of the anastomosis site) were evaluated according to a four-tiered system (score 0-3).…”

Section: Methodsmentioning

confidence: 99%

“…We used a modified histologic scoring system developed specifically for this study based on the scoring system suggested in previous studies. 7,9 According to the scoring system, the extent of polymorphonuclear leukocyte infiltration at the anastomosis site was graded as "0" if none, and graded as "3" if extensive. All other morphologic parameters were evaluated according to the same principle.…”

Section: Methodsmentioning

confidence: 99%

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The Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomoses

Yurtçu

Baba

2012

Renal Failure

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Objectives: This study aimed to investigate the effect of natrium hyaluronate (NH) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA). Materials and methods: Eighteen rabbits were divided equally into three groups: surgical (S), sham (Sh), and NH. A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were injected with saline (Sh group) and NH (NH group) into anastomoses lines after the surgical procedure. The S group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelialization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later. Main findings: There were no significant differences in the GTFM scores in the S group compared with those in the NH group. In the NH group, N scores were higher than they were in the S group. Re-epithelialization in the NH group was higher than it was in the S group. Principle conclusions: NH did not decrease fibrosis, but increased important parameters in wound healing such as neovascularization and re-epithelialization in an experimental model of PUA in rabbits.

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Section: Discussionmentioning

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomoses

Yurtçu

Baba

2012

Renal Failure

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“…3) synthesis of scaffolds with biosignals for cell development, which are normally present in the cell (growth promoters, cell differentiation and proliferation) (Fedakar-Senyucel et al 2008).…”

Section: Definition Of Tissue Engineeringmentioning

confidence: 99%

Chitosan – a promising biomaterial in veterinary medicine

Drewnowska¹,

Turek²,

Carstanjen³

et al. 2013

Polish Journal of Veterinary Sciences

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Biomaterials originate from natural substances and are widely used in medicine. Although they have to satisfy many conditions to be useful for treatment, more and more research is carried out with new types of biomaterials that can help replace various tissues such as tendons and bones. Chitosan is a very promising material, revealing unique features, which makes it useful for veterinary medicine -antimicrobial activity, biocompatibility, biodegradability. It is also known as good scaffold material, especially when combined with other polymers. This article describes chitosan as a biomaterial and tissue engineering scaffold with possible applications in veterinary medicine.

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“…Some water-soluble polymers are especially useful because of the safety in which the film is prepared and applied to humans. For example, gelatin polypeptide is the most popular one for film formation and has been used as the base for capsule preparation [7]. First, aqueous gelatin solution is prepared, and then, a cross-linking agent such as glutaraldehyde is added to stabilize the film.…”

Section: Introductionmentioning

confidence: 99%