The effects of long term feeding ofSolanum glaucophyllum to growing rats on Ca, Mg, P and bone metabolism

Puche, R. C.; Locatto, M. E.; Ferretti, J.L.; Fernández, M.C.; Orsatti, M.; Valenti, J. L.

doi:10.1007/bf02546401

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Even the 250-mg dose was approximately 60 times greater than that used to reproduce the disease in cattle, when compared on a gram per kilogram basis [5,6]. The dietary calcium level in the present study, 0.4%, although close to recommended levels [16], was somewhat lower than that used by others [6]. It is possible, although not considered likely, that this represented a limiting factor in eliciting a dose response.…”

Section: Discussioncontrasting

confidence: 48%

“…There are considerable species differences in the dose response to Solanum, and rats have been noted to be relatively resistant [6]. Even the 250-mg dose was approximately 60 times greater than that used to reproduce the disease in cattle, when compared on a gram per kilogram basis [5,6]. The dietary calcium level in the present study, 0.4%, although close to recommended levels [16], was somewhat lower than that used by others [6].…”

Section: Discussionsupporting

confidence: 37%

“…The increased bone formation could be a direct effect of Solanum on bone-forming cells or associated with the increase in serum calcium that was seen. The elevation of serum calcium was probably the result of its increased intestinal absorption, a well-documented effect of Solanum [6,9].…”

Section: Discussionmentioning

confidence: 96%

“…This may represent an inability of the rats to utilize more than a certain amount of the plant. There are considerable species differences in the dose response to Solanum, and rats have been noted to be relatively resistant [6]. Even the 250-mg dose was approximately 60 times greater than that used to reproduce the disease in cattle, when compared on a gram per kilogram basis [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…The cause of the hyperostosis is unclear. Observations on naturally affected or experimental animals have suggested that either increased bone formation [4][5][6] or inhibition of bone resorption [7] may play a role.…”

mentioning

confidence: 99%

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Acute effects ofSolanum malacoxylon on bone formation rates in growing rats

et al. 1979

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The plant Solanum malacoxylon is responsible for a syndrome of hypercalcemia, soft tissue mineralization, and progressive wasting in South American cattle known as enteque seco or espichamento. There is evidence that a glycoside of 1,25-dihydroxycholecalciferol is the active principle in the plant. The basis for the hyperostosis seen in the disease is unclear. To study the acute effects on bone formation rates, 8-week-old rats were given an aqueous extract equivalent to 250 or 1000 mg of Solanum daily per os for 7 days. Bones were labeled by injection of fluochrome 2 days before the start of treatment and 2 days prior to sacrifice. Morphometric evaluation of undecalcified sections of caudal vertebrae revealed an increased amount of trabecular bone in both Solanum treated groups with no difference due to dose level. This was associated with an increase in the bone apposition rate on trabecular surfaces. No differences were found in the amount of osteoid seam width. Periosteal apposition rate and endochondral bone formation were also measured and no significant differences found. The findings indicate that acute stimulation of cell level bone formation on trabecular surfaces may play a role in the hyperostosis seen in the naturally occurring condition.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionsupporting

confidence: 37%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Acute effects ofSolanum malacoxylon on bone formation rates in growing rats

et al. 1979

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Influence of partially purified extracts ofSolanum malacoxylon on bone resorption in organ culture

Liskova-Kiar

Proschek

1978

Calc. Tis Res.

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Long-term effects of high or low Ca intakes and of lack of parathyroid function on rat femur biomechanics

et al. 1985

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In order to assess the repercussion of chronically affected parathyroid function on bone biomechanics, 3-point flexion tests were carried out with fresh, whole femurs of young, intact rats fed diets with low, normal, or high Ca contents, and thyroparathyroidectomized (TPTX) rats fed normal Ca diet. Ca-restriction reduced, and TPTX augmented, inertial parameters and load-resistance of the whole femurs, not affecting the bending stress or the modulus of elasticity of the bone material, suggesting that parathyroid status affected bone mass and architecture without biomechanical alteration of bone tissue. High-Ca feeding enhanced tissue strength and stiffness as a direct effect, not altering bone geometry. The relationships between the energy-absorbing capacity of the whole bones or of the bone tissue, and the moment of inertia of the fracture sections in weight-paired animals showed that (1) in intact rats under normocalcic diet, the inertia of the section was unrelated to the whole-bone biomechanical performance, while bone section architecture depended on bone tissue biomechanical quality; and (2) in the absence of the parathyroids, or in chronically-induced hyperparathyroidism, this last relationship did not apply, but section architecture had a major influence on the whole-bone biomechanics, independently of physiological stresses. The evidence obtained can be interpreted to indicate that architectural changes brought about by the parathyroids contribute to the regulation of bone biomechanics by adapting organ inertial parameters to tissue quality.

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The effects of long term feeding ofSolanum glaucophyllum to growing rats on Ca, Mg, P and bone metabolism

Cited by 8 publications

References 26 publications

Acute effects ofSolanum malacoxylon on bone formation rates in growing rats

Acute effects ofSolanum malacoxylon on bone formation rates in growing rats

Influence of partially purified extracts ofSolanum malacoxylon on bone resorption in organ culture

Long-term effects of high or low Ca intakes and of lack of parathyroid function on rat femur biomechanics

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