The effects of low-dose 2-hydroxyethyl methacrylate on apoptosis and survival in human dental pulp cells

Chen, Rung-Shu; Lee, Ming‐Shu; Hu, Yu-Jen; Hu, Chia-Yuan; Tseng, Wan-Yu

doi:10.1016/j.jfma.2020.11.022

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been speculated that incompletely polymerized RMGICs may release a substantial amount of unreacted HEMA monomers. These monomers may diffuse readily through the dentin barrier into the dentin–pulp complex due to their low molecular weight (130.14 g/mol) and hydrophilicity [ 20 ]. Furthermore, poor waste management in dental clinics may increase the risk of monomer contact with dental health care personnel or the contamination of the environment.…”

Section: Introductionmentioning

confidence: 99%

Monomer Conversion, Dimensional Stability, Biaxial Flexural Strength, Ion Release, and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Methacrylate-Functionalized Polyacids and Spherical Pre-Reacted Glass Fillers

et al. 2021

View full text Add to dashboard Cite

The aim of this study was to prepare RMGICs for pulp protection that contain polyacids functionalized with methacrylate groups (CMs) to enable light-activated polymerization without the need for toxic 2-hydroxyethyl methacrylate (HEMA) monomers. The effects of using CM liquids with 0 or 5 wt% HEMA on the physical/mechanical properties and cytotoxicity of the experimental RMGICs were assessed. Spherical pre-reacted glass fillers (SPG) were used as the powder phase. The experimental RMGICs were prepared by mixing SPG with CM liquid (0 wt% HEMA, F1) or CMH liquid (5 wt% HEMA, F2). Commercial materials (Vitrebond, VB; TheraCal LC, TC) were used for the comparisons. The degree of monomer conversion and fluoride release of both F1 and F2 were significantly lower than those of VB. F1 showed comparable biaxial flexural strength with VB but higher strength than TC. The dimensional stability (mass/volume changes) of the experimental materials was comparable with that of the commercial materials. F1 and F2 exhibited higher Sr/Ca ion release and relative cell viability than VB. The use of CMH liquid reduced the strength but enhanced the fluoride release of the experimental RMGICs. In conclusion, the experimental RMGICs showed comparable strength but lower cytotoxicity compared to the commercial RMGICs. These novel materials could be used as alternative materials for pulp protection.

show abstract

Section: Introductionmentioning

confidence: 99%