The effects of low-level laser therapy on the healing of bone defects in streptozotocin-induced diabetic rats: A histological and morphometric evaluation

Yildirimturk, Senem; Sirin, Yigit; Tekkeşın, Merva Soluk; Gürler, Gökhan; Fırat, Deniz

doi:10.1080/14764172.2017.1341048

Cited by 15 publications

(16 citation statements)

References 36 publications

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“…PBMT involves radiation from the red to infrared regions, with the latter being most cited in the literature as effective in the early stages of bone repair during the reconstruction process. This is because, at the early stages, there is a large amount of differentiating cells, and reduction of these cells at a late time of repair reduces the PBMT-related osteostimulatory potential [25,48,64].…”

Section: Discussionmentioning

confidence: 99%

“…Most experimental and clinical studies describe that PBMT aids in the process of tissue regeneration, demonstrating biological modulatory effects on cell differentiation [9,16,17]. Photobiomodulation of bone tissue seems to increase the results of fracture repair [18], periodontal tissue [19], implant osseointegration [20] and bone reconstruction with or without biomaterials [15,[21][22][23][24][25]. Its application in clinical practice with the purpose of assisting healing after bone graft reconstruction surgery [26] is still poorly described in the scientific literature.…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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The use of low-level laser therapy (LLLT) with biomodulatory effects on biological tissues, currently called photobiomodulation therapy (PBMT), assists in healing and reduces inflammation. The application of biomaterials has emerged in bone reconstructive surgery, especially the use of bovine bone due to its biocompatibility. Due to the many benefits related to the use of PBMT and bovine bones, the aim of this research was to review the literature to verify the relationship between PBMT and the application of bovine bone in bone reconstruction surgeries. We chose the PubMed/MEDLINE, Web of Science, and Scopus databases for the search by matching the keywords: “Bovine bone AND low-level laser therapy”, “Bovine bone AND photobiomodulation therapy”, “Xenograft AND low-level laser therapy”, and “Xenograft AND photobiomodulation therapy”. The initial search of the three databases retrieved 240 articles, 18 of which met all inclusion criteria. In the studies concerning animals (17 in total), there was evidence of PBMT assisting in biomaterial-related conduction, formation of new bone, bone healing, immunomarker expression, increasing collagen fibers, and local inflammation reduction. However, the results disagreed with regard to the resorption of biomaterial particles. The only human study showed that PBMT with bovine bone was effective for periodontal regeneration. It was concluded that PBMT assists the process in bone reconstruction when associated with bovine bone, despite divergences between applied protocols.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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“…For example, studies found that LLI could promote the regeneration of gastrocnemius muscle after cold injury and enhance neovascularization after injury, indicating a potential role of PBM on regeneration and angiogenesis after muscle injury [209,210]. In addition, the beneficial effects of PBM have been experimentally demonstrated on recurrent aphthous stomatitis, skin burn injuries, diabetes mellitus, sports injuries, and osteoarthritis [211][212][213][214][215][216]. Most significantly, PBM is able to confer its photobiological effect at the cellular level without thermal and toxic effects [217].…”

Section: Methylene Blue and Photobiomodulation As Therapeutic Approachesmentioning

confidence: 99%

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

Yang

Youngblood

et al. 2020

Transl Neurodegener

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Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease. Ample evidence suggests mitochondria are a promising target for neuroprotection. Recently, methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative injury. This review will discuss two widely studied approaches for the improvement of brain mitochondrial respiration, methylene blue (MB) and photobiomodulation (PBM). MB is a widely studied drug with potential beneficial effects in animal models of brain disease, as well as limited human studies. Similarly, PBM is a non-invasive treatment that promotes energy production and reduces both oxidative stress and inflammation, and has garnered increasing attention in recent years. MB and PBM have similar beneficial effects on mitochondrial function, oxidative damage, inflammation, and subsequent behavioral symptoms. However, the mechanisms underlying the energy enhancing, antioxidant, and anti-inflammatory effects of MB and PBM differ. This review will focus on mitochondrial dysfunction in several different brain diseases and the pathological improvements following MB and PBM treatment.

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“…[6][7][8] One of the debated treatment modalities, despite its common use, is low-level laser therapy (LLLT) [9][10][11][12][13][14] that is used in the treatment of many diseases. [15][16][17][18][19][20] Imani et al and Munguia et al concluded that almost 60% of the literature between 2000 to 2018 demonstrated that LLLT was useful in reducing pain and trigger point sensitivity, improving the quality of life. 21,22 Momenzadeh et al 23 reached the same result.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of the Polarized Low-Level Laser in the Treatment of Patients With Myofascial Trigger Points in the Trapezius Muscles

2020

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Introduction: This study assessed the effect of polarized low-level laser therapy (PLLLT) on the treatment of myofascial trigger points (MTrPs) in the trapezius muscles. Its effectiveness in pain reduction was compared to low-level laser therapy (LLLT). Methods: Sixty-four patients with MTrPs were randomly divided into 2 groups, namely PLLLT and LLLT. Each patient received treatment for a period of 2 weeks, 5 sessions a week. The intensity of laser irradiation to the skin surface was 6 J/cm 2 . The system exit power was 160 mw at a 755 nm wavelength. The visual analog scale (VAS) for the 1st, 5th and 10th sessions was analyzed through two-way repeated measures ANOVA. Results: Increasing the number of treatment sessions was effective in reducing pain intensity (P > 0.05). The effect of LLLT on pain reduction was significantly greater than that of PLLLT (P > 0.05). Referred pain (RP), the limitation of neck movement (LNM), the presence of muscular taut band (PMTB) and the sensitivity of muscular taut band (SMTB) were reduced significantly by the end of the 10th session, compared with participants' condition at the beginning of the 1st session in both groups. Conclusion: PLLLT and LLLT can effectively treat MTrPs in the trapezius muscles and they reduce RP, LNM, PMTB, and SMTB in particular. However, the effect of the LLLT was significantly greater than that of PLLLT. In accordance with the observed results, LLLT is recommended as an effective method for treating MTrPs.

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The effects of low-level laser therapy on the healing of bone defects in streptozotocin-induced diabetic rats: A histological and morphometric evaluation

Abstract: LLLT application promoted vascularization and new bone formation in animals with DM to a limited extent, since it was unable to support the healing process up to the level of non-diabetic animals.

Cited by 15 publications

References 36 publications

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

The Effectiveness of the Polarized Low-Level Laser in the Treatment of Patients With Myofascial Trigger Points in the Trapezius Muscles

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