The Effects of &lt;b&gt;&lt;i&gt;Lysimachia christinae Hance&lt;/i&gt;&lt;/b&gt; Extract Fractions on Endothelium-Dependent Vasodilatation

Zhang, Fei-Xue; Liu, Xiufen; Ke, Zhiqiang; Wu, Ning-hua; Chen, Hongguang; Liu, Chao

doi:10.1159/000500011

Cited by 8 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extracts of these plants are known to contain polyphenols [37] and saponins [38]. It has been shown that extracts of species of the Lysimachia genus have antioxidant [39][40][41], anthelmintic [42], antimicrobial [43], and endothelioprotective effects [41], and they can improve the vasodilating function of the endothelium [44], inhibit lipogenesis processes [36], and exhibit therapeutic effects on neurodegenerative diseases [45].…”

Section: Introductionmentioning

confidence: 99%

The Content of Certain Groups of Phenolic Compounds and the Biological Activity of Extracts of Various Halophyte Parts of Spergularia marina (L.) Griseb. and Glaux maritima L. at Different Levels of Soil Salinization

Pungin

Lartseva

Loskutnikova

et al. 2022

Plants

View full text Add to dashboard Cite

Halophyte plants are known for their resistance to harsh environmental conditions associated with excess salts in their habitats. Their resistance to salinization is due, among other things, to their high ability to detoxify free radicals, owing to the relatively high content of antioxidants. On the coast of the Baltic Sea and in the lagoons, there are several rare halophyte species included in the Red Book of the Kaliningrad Region (Russia) and the Baltic region, such as Spergularia marina (L.) Griseb. and Glaux maritima L. The aim of the research was to study the accumulation of certain groups of phenolic compounds in different parts of S. marina and G. maritima plants under conditions of weak and strong soil salinity, as well as to analyze the antioxidant, antibacterial, and fungicidal activity of extracts of the studied plant species. The present study showed an increase in total phenolic content in the roots and shoots of S. marina, and the shoots of G. maritima, in response to increased soil salinity. At the same time, the total content of flavonoids in all the studied parts of the two plant species remained unchanged. However, the content of individual flavonoids (hesperetin, epicatechin, apigenin derivative, luteolin derivative) in S. marina increased, for G. maritima there was a tendency to reduce the content of flavonoids in roots and shoots with an increase in soil salinity. There was an increase in the total content of hydroxycinnamic acids in the roots of Glaux maritima, as well as an increase in the content of protocatechuic acid in the roots and shoots of Spergularia marina. A positive relationship was established between the antioxidant activity of S. marina root extracts and the total content of phenolic compounds, as well as G. maritima shoots extracts and the total content of phenolic compounds. Extracts of S. marina showed no antibacterial activity against Escherichia coli and Bacillus subtilis, and weak fungicidal activity of stem extracts and inflorescences grown on soils, with high levels of salinities, was detected against Candida albicans. The extracts of roots and shoots from G. maritima showed weak antimicrobial and fungicidal activity.

show abstract

Section: Introductionmentioning

confidence: 99%

The Content of Certain Groups of Phenolic Compounds and the Biological Activity of Extracts of Various Halophyte Parts of Spergularia marina (L.) Griseb. and Glaux maritima L. at Different Levels of Soil Salinization

Pungin

Lartseva

Loskutnikova

et al. 2022

Plants

View full text Add to dashboard Cite

show abstract

“…Among various types of TCM for the treatment of urolithiasis, Lysimachia christinae Hance (Jin Qian Cao), a herbaceous plant of the family Primulaceae, is widely used for treating hepatobiliary lithiasis, urolithiasis, biliary calculus, etc . On account of its various medicinal values as an herb, it has been increasingly investigated for its chemical constituent analyses and therapeutic potential. − Gallic acid (GaA), a dietary polyphenolic acid that has antioxidative, antibacterial, and anticancer properties, is one of the most important polyphenols in Jin Qian Cao . However, the effect of gallic acid on the formation of kidney stones, specifically the crystallization of calcium oxalate, has rarely been investigated.…”

Section: Introductionmentioning

confidence: 99%

A New Perspective of Gallic Acid on Calcium Oxalate Nucleation

Tang

Shi

et al. 2020

Crystal Growth & Design

View full text Add to dashboard Cite

The therapeutics for nephrolithiasis have created an awareness of the potential effects of crystal modifiers on the biocrystallization process. The crystallization of calcium oxalate, a primary constituent of kidney stones, is confirmed to be inhibited by natural or synthetic modifiers, but the induction of calcium oxalate dihydrate and trihydrate, which is likewise effective for retardation of stone formation, is rarely focused on. Herein, we performed a systematic investigation of the effect of gallic acid, a natural polyphenol, on the nucleation of calcium oxalate from both experimental and simulation approaches. Our results reveal that the solution species of gallic acid alter the nucleation pathways of calcium oxalate and induce the formation of different types of amorphous structures corresponding to calcium oxalate hydrates. Different species of gallic acid regulate the formation of three types of amorphous calcium oxalates (ACOs) by incorporating the proper water contents and specific interactions. Fluorescence microscopy further demonstrates clearly the incorporation of gallic acid in the nucleated calcium oxalate precipitates. These findings unveil the nucleation mechanism of different calcium oxalate hydrates with the inclusion of modifiers and provide insights for an understanding of stone formation and its potential inhibitors.

show abstract

“…Rutin, a natural flavone derivative, has powerful antioxidant capacity by scavenging free radicals and chelating metals in vivo and in vitro (Javed et al, 2012;Kamalakkannan, Stanely, & Prince, 2006;Magalingam, Radhakrishnan, & Haleagrahara, 2013). Previous studies have shown that the components of LHE may contribute to its potent antioxidant effects by preventing hydrogen peroxide (H 2 O 2 )-induced oxidative stress (Wu et al, 2018;Zhang, Liu, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Rutin, a natural flavone derivative, has powerful antioxidant capacity by scavenging free radicals and chelating metals in vivo and in vitro (Javed et al., 2012; Kamalakkannan, Stanely, & Prince, 2006; Magalingam, Radhakrishnan, & Haleagrahara, 2013). Previous studies have shown that the components of LHE may contribute to its potent antioxidant effects by preventing hydrogen peroxide (H 2 O 2 )‐induced oxidative stress (Wu et al., 2018; Zhang, Liu, 2019). Our previous study also revealed that LHE has high antioxidant activities as tested by 2,2′‐azino‐bis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) and 2,2′‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing antioxidant power (FRAP), and reducing power assay (Lee, 2019).…”

Section: Discussionmentioning

confidence: 99%

Lysimachia christinae Hance as an anticancer agent against breast cancer cells

Kim

Lee

et al. 2020

Food Science & Nutrition

View full text Add to dashboard Cite

Breast cancer is the most common cancer in women, and metastasis is the leading cause of death in breast cancer patients. Although chemoprevention is widely employed to treat breast cancer, anticancer drugs can cause significant adverse effects. Lysimachia christinae Hance (LH) is a traditional Chinese medicinal plant with diverse therapeutic effects. However, its potential anticancer activity has not been fully investigated in breast cancers to date. Using high‐performance liquid chromatography–mass spectrometry, we found that the main constituent of LH extract (LHE) was rutin. Our results indicated that LHE or rutin markedly decreased the proliferation and viability of estrogen receptor (ER)‐positive MCF‐7 and ER‐negative HCC38 human breast cancer cells. LHE treatment induced morphological changes in apoptotic nuclei using 4′,6‐diamidino‐2‐phenylindole (DAPI) staining. Annexin V–fluorescein isothiocyanate (FITC) propidium iodide (PI) staining assay revealed that apoptosis significantly increased in both breast cancer cell types after LHE treatment. Additionally, the expression of poly (ADP‐ribose) polymerase (PARP), Bcl‐2, and phospho‐Akt decreased, while that of cleaved PARP and p53 increased, in both cell types. Furthermore, LHE treatment inhibited epithelial–mesenchymal transition (EMT). LHE treatment significantly upregulated E‐cadherin level in MCF‐7 and HCC38 cells, while vimentin level was downregulated in HCC38 cells. In addition, transwell and wound‐healing assays revealed that LHE or rutin inhibited breast cancer cell migration. Overall, these findings demonstrate that LHE is a promising therapeutic agent that acts by promoting apoptosis and reducing cell proliferation, EMT, and cell migration in ER‐positive and ER‐negative breast cancer cells.

show abstract

The Effects of <b><i>Lysimachia christinae Hance</i></b> Extract Fractions on Endothelium-Dependent Vasodilatation

Cited by 8 publications

References 20 publications

The Content of Certain Groups of Phenolic Compounds and the Biological Activity of Extracts of Various Halophyte Parts of Spergularia marina (L.) Griseb. and Glaux maritima L. at Different Levels of Soil Salinization

The Content of Certain Groups of Phenolic Compounds and the Biological Activity of Extracts of Various Halophyte Parts of Spergularia marina (L.) Griseb. and Glaux maritima L. at Different Levels of Soil Salinization

A New Perspective of Gallic Acid on Calcium Oxalate Nucleation

Lysimachia christinae Hance as an anticancer agent against breast cancer cells

Contact Info

Product

Resources

About