The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Asbaghi, Omid; Hosseini, Rozita; Boozari, Behnoosh; Ghaedi, Ehsan; Kashkooli, Sara; Moradi, Sajjad

doi:10.1007/s12011-020-02157-0

Cited by 41 publications

(35 citation statements)

References 52 publications

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“…In the human body, magnesium is a cofactor in several enzyme systems such as Na + /K + -ATPase, hexokinase, creatine kinase, protein kinase. Also, magnesium plays a role in signal transduction, protein synthesis, neuromuscular conduction,, muscle and nerve transmission, blood glucose control, and blood pressure regulation [ 37 38 39 ]. Abnormal magnesium homeostasis can lead to metabolic disorders, such as diabetes [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zamani

Haghighat

2022

Clin Nutr Res

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The aim of this systematic review and meta-analysis was to summarize all the existing randomized controlled trials (RCTs) evidence and to evaluate the effects of magnesium supplementation on serum magnesium, calcium and urinary magnesium concentrations in patients with type 2 diabetes compared with the control. Two independent authors systematically searched online databases including Embase, Scopus, PubMed, and Web of Science from inception until 30th January 2022. RCTs complying with the inclusion criteria were included in this meta-analysis. The heterogeneity among the included studies was assessed using Cochrane’s Q test and I-square (I 2 ) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Sixteen trials were included in this meta-analysis. Serum magnesium (mean difference, 0.15 mg/dL; 95% confidence interval [CI], 0.06 to 0.23; p = 0.001) and urinary magnesium (WMD, 1.99 mg/dL; 95% CI, 0.36 to 3.62; p = 0.017) concentrations were significantly increased after magnesium supplementation when compared with the control group. However, magnesium supplementation did not have any significant effect on serum calcium (WMD, −0.09 mg/dL; 95% CI, −0.27 to 0.08; p = 0.294) level when compared with the control group. This meta-analysis demonstrated that magnesium supplementation significantly increased Serum magnesium levels which may have played an indirect role in improved clinical symptoms in patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zamani

Haghighat

2022

Clin Nutr Res

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“…Magnesium, ein essenzieller Mineralstoff, ist u. a. am intrazellulären Kohlenhydratstoffwechsel, der Insulinsekretion und -signalkaskade, dem Lipidstoffwechsel und der Regulation des Blutdrucks beteiligt [352]. Die Evidenz zur Wirkung einer Magnesium-Supplementation auf die glykämische Kontrolle und den Blutdruck bei Personen mit T2Dm ist widersprüchlich [352][353][354]. Nach Supplementation mit Magnesium vs.…”

Section: Ddg-praxisempfehlungunclassified

Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

Skurk

Bosy‐Westphal

Grünerbel³

et al. 2021

Diabetologie und Stoffwechsel

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“…These results were consistent with some previous studies, which reported that tobacco smoking [31] and alcohol drinking [32] behaviors may be associated with decrease in blood magnesium concentrations. But some other studies suggested that blood magnesium was inversely associated with BMI [33], TG [34], and blood pressure [35]. Of note, although the significantly inverse association between folate and magnesium levels in the univariate analysis, there was no significant relation of folate with magnesium in the multivariate models ( p = 0.937).…”

Section: Discussionmentioning

confidence: 86%

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Lin

Song

et al. 2020

Ann Nutr Metab

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Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33–5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12–3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.

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The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 41 publications

References 52 publications

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

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