The Effects of Magnetic Field on the Biomechanics Parameters of Soleus and Extensor Digitorum Longus Muscles in Rats with Streptozotocin-Induced Diabetes

Pelit, Aykut; Özaykan, Besim; Tuli, Abdullah; Demirkazık, Ayşe; Emre, Mustafa; Günay, İsmail

doi:10.1089/dia.2007.0280

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…In addition, the CT and HRT of the rats in group DM were found to be prolonged compared to group C ( p < 0.05). On the other hand, the maximal tetanic force values obtained from skeletal muscles for the groups treated with antioxidant treatment increased significantly ( p < 0.05) in comparison with group DM and group C. We observed that tetanic contraction forces improvement was 3-4 times greater than the isometric contraction force, which correlates with the results from our previous study [ 17 , 36 ].…”

Section: Discussionsupporting

confidence: 89%

Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin‐Induced Diabetic Rats

Taştekin

Pelit

Polat

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Aims The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4′-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4′ trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats. Materials and Methods At the end of the 5-week experimental period, the right gastrocnemius muscles of the rats were examined biomechanically, while the left ones were examined histologically. In addition, blood glucose, serum insulin, and malondialdehyde (MDA) levels were analyzed in blood samples taken from the rats. Results The skeletal muscle isometric contraction forces, which showed a decrease with diabetes, were observed to increase with antioxidant applications. Blood glucose, serum insulin, and MDA levels in diabetic rats approached normal levels after applying PTS. When the electron microscopic images of the rat skeletal muscle were examined, those in the combination treatment group were observed to show a better enhancement in the skeletal muscle morphological structure compared to the other diabetic and treatment groups. Conclusion According to the findings, we suggest that these antioxidant treatments might have good therapeutic nutraceutical potential for some muscle diseases that coexist with diabetes. These treatments should be comprehensively investigated in the future.

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Section: Discussionsupporting

confidence: 89%

Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin‐Induced Diabetic Rats

Taştekin

Pelit

Polat

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, the blood glucose levels for diagnosing diabetes in humans during fasting and 2 h postprandial are 7.0 mmol/L (126 mg/dL) or greater and 11.1 mmol/L (200 mg/dL) or greater [28] , respectively, and the situation for diabetic rats is that they can be considered as diabetic with blood glucose levels of 300 mg/dL (16.7 mmol/L) [7] . The J48 algorithm used the Twitch (mN/mm 2 ) feature to classify the data in the set.…”

Section: Resultsmentioning

confidence: 99%

“…Experimentally induced diabetes is associated with changes in the contractile and electrical properties of skeletal muscles. The soleus and extensor digitorumlongus (EDL) are important skeletal muscles that play important roles in standing to the gravity force and exercises [7] . At the same time, atrophy may develop (muscle loss) in skeletal muscles and results in decreased muscle strength.…”

Section: Introductionmentioning

confidence: 99%

PCA Destekli J48 Algoritmasıİle Manyetik Alanla Tedavi Edilen Diyabetik Sıçanların Biyokimyasal ve Biyomekanik Verilerinin Sınıflandırılması

Pelit¹,

Ibeikci²,

Ozalp³

et al. 2019

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the J48 mediated decision tree algorithm from the principal component analysis-PCA, which is more complex, one of the statistical algorithms of diabetic metabolic disorders of Wistar albino rats' biochemical values and magnetic field application. Wistar Albino rats were examined under 4 different groups including the control group. When the results were examined, it was observed that PCA increased the success rate of classification from 96.25% to 97.50% when used with J48 decision tree algorithm. Thus, the PCA-supported J48 algorithm demonstrated that Wistar albino rats could be successfully used on the data obtained from more complex diabetic metabolic values.

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“…In muscle cells, SERCA promotes relaxation by pumping calcium ions from the cytosol into the lumen of the SR, the main storage compartment for intracellular calcium (Primeau et al, 2018). In another study that investigated the effect of MF on the isometric contraction properties of soleus and extensor digitorum longus muscles in rats, it has been reported that MF increases both muscle contraction forces compared to control values (Pelit et al, 2008). Also, MF decreased the contraction time of the two muscles of rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of extremely low-frequency electromagnetic field exposure on the skeletal muscle functions in rats

et al. 2020

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The aim of the present study was to systematically investigate the effects of chronic exposure to extremely low-frequency electromagnetic field (ELF-EMF) on electrophysiological, histological and biochemical properties of the diaphragm muscle in rats. Twenty-nine newly weaned (24 days old, 23–80 g) female ( n = 15) and male ( n = 14) Wistar Albino rats were used in this study. The animals were randomly divided into two groups: the control group and the electromagnetic field (EMF) group. The control group was also randomly divided into two groups: the control female group and the control male group. The EMF exposure group was also randomly divided into two groups: the ELF-EMF female group and the ELF-EMF male group. The rats in the ELF-EMF groups were exposed for 4 h daily for up to 7 months to 50 Hz frequency, 1.5 mT magnetic flux density. Under these experimental conditions, electrophysiological parameters (muscle bioelectrical activity parameters: intracellular action potential and resting membrane potential and muscle mechanical activity parameter: force–frequency relationship), biochemical parameters (Na+, K+, Cl− and Ca+2 levels in the blood serum of rats; Na+-K+ ATPase enzyme-specific activities in muscle tissue; and free radical metabolism in both muscle tissue and serum) and transmission electron microscopic morphometric parameters of the diaphragm muscle were determined. We found that chronic exposure to ELF-EMF had no significant effect on the histological structure and mechanical activity of the muscle and on the majority of muscle bioelectrical activity parameters, with the exception of some parameters of muscle bioelectrical activity. However, the changes in some bioelectrical activity parameters were relatively small and unlikely to be clinically relevant.

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The Effects of Magnetic Field on the Biomechanics Parameters of Soleus and Extensor Digitorum Longus Muscles in Rats with Streptozotocin-Induced Diabetes

Abstract: In our study, these results suggest that MF exposure regulates the isometric contractile characteristics of the soleus and EDL muscles of rats with diabetes, positively.

Cited by 9 publications

References 17 publications

Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin‐Induced Diabetic Rats

Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin‐Induced Diabetic Rats

PCA Destekli J48 Algoritmasıİle Manyetik Alanla Tedavi Edilen Diyabetik Sıçanların Biyokimyasal ve Biyomekanik Verilerinin Sınıflandırılması

Effects of extremely low-frequency electromagnetic field exposure on the skeletal muscle functions in rats

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