The Effects of Mindfulness Meditation-Based Complex Exercise Program on Motor and Nonmotor Symptoms and Quality of Life in Patients with Parkinson's Disease

Son, Hye-Gyeong; Choi, Eun Suk

doi:10.1016/j.anr.2018.06.001

Cited by 33 publications

(69 citation statements)

References 23 publications

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“…The beneficial effects of mindfulness were most pronounced on anxiety and depressive symptoms. This is in line with previous studies that tested the effect of mindfulness-based interventions in PD patients: improvements in depressed mood were seen in six out of eight studies 27 , 40 – 44 , improvement in anxiety in four out of seven studies 27 , 40 – 42 , 44 , and improvement of motor symptoms in two out of three studies 27 , 45 that measured these symptoms. The focus of mindfulness on the present moment might discourage past-oriented ruminative thoughts, explaining the beneficial effects on mood and anxiety.…”

Section: Discussionsupporting

confidence: 91%

Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

Heide

Speckens

Faber³

et al. 2021

npj Parkinsons Dis.

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Many Parkinson’s disease (PD) patients notice that motor symptoms worsen during stress, and experience stress-related neuropsychiatric symptoms such as anxiety and depression. Here we investigated which personal and disease characteristics are associated with perceived stress in PD, which PD symptoms are sensitive to stress, and we assessed self-reported benefits of stress-reducing strategies such as mindfulness. We sent an online survey to the Fox Insight cohort (n = 28,385 PD patients, n = 11,413 healthy controls). The survey included specific questions about the influence of stress on PD symptoms, use of stress-reducing strategies, and several validated scales measuring perceived stress, anxiety, dispositional mindfulness, rumination, and self-compassion. We received completed surveys from 5000 PD patients and 1292 controls. Patients perceived more stress than controls. Among patients, stress was correlated with increased rumination (R = 0.65), lower quality of life (R = −0.56), lower self-compassion (R = −0.65), and lower dispositional mindfulness (R = −0.48). Furthermore, patients indicated that stress significantly worsened both motor symptoms – especially tremor – and non-motor symptoms. Physical exercise was most frequently used to reduce stress (83.1%). Mindfulness was practiced by 38.7% of PD respondents, who noticed improvement in both motor and non-motor symptoms. Among non-users, 43.4% were interested in gaining mindfulness skills. We conclude that PD patients experience greater levels of stress than controls, and that stress worsens both motor and non-motor symptoms. Mindfulness may improve PD symptom severity, with the strongest effects on anxiety and depressed mood. These findings justify further controlled studies to establish the merits of mindfulness and other stress-alleviating interventions.

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Section: Discussionsupporting

confidence: 91%

Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

Heide

Speckens

Faber³

et al. 2021

npj Parkinsons Dis.

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“…With regard to anxiety and depression rating scales, MCIDs in PD populations have only been established for the Beck Depression Inventory, 15 Geriatric Depression Scale (GDS)-30, 16 and Hospital Anxiety and Depression Scale (HADS) 17 (Supporting Information). From this we can conclude that the improvement in HADS-D depression score of 2.6 points and in HADS-A anxiety score of 2.4 points reported by Kwok et al 18 is likely clinically relevant (HADS-D: MCID = 1.7 points; HADS-A: MCID = 1.8 points), whereas the improvement in GDS-30 depression of 3.4 points reported by Son et al 19 is not (MCID = 5.4). For motor symptoms, all trials used Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III) scores as an outcome measure, for which the MCID threshold was estimated to be 3.25 points.…”

Section: Clinical Effect Of Mindfulness-based Interventionsmentioning

confidence: 53%

Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms

Heide

Meinders²,

Speckens

et al. 2020

Movement Disorders

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Patients with Parkinson's disease (PD) are very vulnerable to the negative effects of psychological distress: neuropsychiatric symptoms, such as anxiety and depression, are highly prevalent in PD; motor symptoms (such as tremor) typically worsen in stressful situations; and dopaminergic medication is less effective. Furthermore, animal studies of PD suggest that chronic stress may accelerate disease progression. Adequate self‐management strategies are therefore essential to reduce the detrimental effects of chronic stress on PD. Mindfulness‐based interventions encourage individuals to independently self‐manage and adapt to the challenges created by their condition. In PD, emerging clinical evidence suggests that mindfulness‐based interventions may reduce psychological distress and improve clinical symptoms, but insight into the underlying mechanisms is lacking. In this viewpoint, we provide a systematic overview of existing mindfulness trials in PD. Furthermore, we discuss the cerebral mechanisms involved in acute and chronic stress, and the impact of mindfulness‐based interventions on these networks. In addition, we delineate a hypothetical mechanistic framework of how chronic stress may increase the susceptibility for neuropsychiatric symptoms in PD and may potentially even influence disease progression. We end with offering recommendations for future research. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

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“…The results presented here are consistent with an expanding body of literature demonstrating the beneficial aspects of exercise and mindfulness on physical performance, cognitive function, and well-being in persons with PD. [18][19][20][21] Our study indicates that such benefits are applicable in a field setting and can be extended over a 12-month period. The positive findings spanning a full year were especially gratifying, given the progressive nature of PD.…”

Section: Discussionmentioning

confidence: 73%

Motor Performance and Quality of Life in a Community Exercise Program for Parkinson Disease

Stiles

Jaffe

Schwartz

et al. 2020

Topics in Geriatric Rehabilitation

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We investigated the effect of a comprehensive community program composed of exercise, mindfulness practice, and education on motor function and quality of life in individuals with Parkinson disease (PD). Thirty-six participants completed physical and quality-of-life assessments independently at baseline and 12 months. Physical assessments showed stability or improvement in functional mobility, integrated strength, and walking ability over the 1-year interval. PDQ-39 measures showed improvement in 6 of 8 indices: mobility, activities of daily living, emotional well-being, stigma reduction, social support, and bodily discomfort. Our results demonstrate the effectiveness of exercise, mindfulness, and education in community and group settings.

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The Effects of Mindfulness Meditation-Based Complex Exercise Program on Motor and Nonmotor Symptoms and Quality of Life in Patients with Parkinson's Disease

Cited by 33 publications

References 23 publications

Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

Stress and mindfulness in Parkinson’s disease – a survey in 5000 patients

Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms

Motor Performance and Quality of Life in a Community Exercise Program for Parkinson Disease

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