The effects of MS-10 dietary supplement, mixture of Korean thistle and thyme extracts, on bone health, and symptoms in menopausal women

Antioxidant Capacity of Thistle (Cirsium japonicum) in Various Drying Methods and their Protection Effect on Neuronal PC12 cells and Caenorhabditis elegans

“…In contrast with our results, however, thermal cooking such as grilling, baking, microwaving, and roasting induced an increase of chlorogenic acid in plants [31,32]. In another example, pre-thermal treatment for a short time even at high-temperature before full drying and extraction has shown a positive effect on the Antioxidants 2020, 9,200 7 of 14 increase in phenolic contents [29][30][31][32][33]. Normally, when heat is applied to plants, it ruptures the tissue, leading to an increase in the bioactive ingredient elution.…”

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

“…MS‐10, a combined herbal extract of Cirsium japonicum and T. vulgaris , produced changes in genes associated with the expression of tumor suppressor and bone health. And it had the potential for improving women's menopausal symptoms, particularly bone health, without side effects …”

“…And it had the potential for improving women's menopausal symptoms, particularly bone health, without side effects. [128] Thymus also has significant anthelmintic activities. For example, T. bovei essential oil exhibited strong anthelmintic activity higher than the used reference standard piperazine citrate and it could be employed as new anthelmintic agents.…”

تأثير حمص الشام المنبت على صحة عظام الفئران المستأصلة المبايض کنموذج لانقطاع الطمث

“…Estrogen deficiency due to menopause affects a woman on all levels, from subcellular structures, organs, regulatory systems to biomentalpsycho-social functioning (Dijket al, 2015).During menopause, estrogen deficiency affects bone metabolism (Noh et al, 2019).Menopause increases bone fragility in women,by decreasingbone mass and bone mineral density (BMD).Estrogen deficiency is associated with an unbalanced between resorption and formation in favour of bone resorption, gradually leading to bone loss (Farlayet al, 2019).Osteoporosis in menopausal women is mainly managed using estrogen replacement therapy (ERT), bisphosphonates, selective estrogen receptor modulators, and calcitonin. Unfortunately, the positive effects of these drugs are counteracted by serious side effects such as increased risk of cancer and thromboembolism.…”

“…Therefore, it is necessary to search for new, less toxic, drugs that can prevent osteoporosis. The potential medical applications of phytochemicals are becoming more recognized in the scientific community and there have been many efforts to identify the effects of natural compounds on bone health in women with menopausal symptoms (Noh et al, 2019).Isoflavone is a chemical compound isolated from di-phenolic secondary metabolites of phtoestrogens with a structure similar to that of human estrogen (Hsiao and Hsieh, 2018). The primary sources of isoflavone in the diet are the plants of the Leguminosae family such as chickpea (Merlantiet al, 2018).…”