The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

Damsgaard, Camilla T.; Mølgaard, Christian; Matthiessen, Jeppe; Gyldenløve, Sedsel N; Lauritzen, Lotte

doi:10.1038/pr.2012.28

Cited by 33 publications

(37 citation statements)

References 37 publications

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“…DHA was positively correlated with BMD of the whole body and the spine at 22 years of age, and with the change in BMD at the spine between 16 and 22 years of age. However, a recent clinical trial provided an n-3 supplement as 900mg of DHA and 200 mg EPA daily to boys aged 13-15 for 16 weeks, and there were no associations between EPA or DHA status and BMC, BMD or markers of bone formation [58]. While the results gathered from animal models thus far would suggest n-3 PUFA intake to be beneficial to bone growth, further large scale clinical trials are needed to ascertain this claim.…”

Section: Timing Of Exposurementioning

confidence: 90%

Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models

et al. 2013

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Incorporating n-3 polyunsaturated fatty acids (PUFA) in the diet may promote the development of a healthy skeleton and thereby reduce the risk of developing osteoporosis in later life. Studies using developing animal models suggest lowering dietary n-6 PUFA and increasing n-3 PUFA intakes, especially long chain n-3 PUFA, may be beneficial for achieving higher bone mineral content, density and stronger bones. To date, the evidence regarding the effects of α-linolenic acid (ALA) remain equivocal, in contrast to evidence from the longer chain products, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This review reports the results of investigations into n-3 PUFA supplementation on bone fatty acid composition, strength and mineral content in developing animal models as well as the mechanistic relationships of PUFA and bone, and identifies critical areas for future research. Overall, this review supports a probable role for essential (ALA) and long chain (EPA and DHA) n-3 PUFA for bone health. Understanding the role of PUFA in optimizing bone health may lead to dietary strategies that promote bone development and maintenance of a healthy skeleton.

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Section: Timing Of Exposurementioning

confidence: 90%

Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models

et al. 2013

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“…In vivo and in vitro studies have indicated that dietary n-3PUFAs may up-regulate the expression of IGF-1, IGF-binding proteins, and TGF-B1, thus enhancing the differentiation of pre-osteoblasts into mature osteoblasts [23]. Furthermore, n-3PUFAs may reduce the expression of peroxisome proliferator-activated receptorγ (PPARr), a transcription factor involved in osteoblast/adipocyte commitment, thus favoring osteoblast differentiation [24]. …”

Section: Discussionmentioning

confidence: 99%

Analyzing the association between fish consumption and osteoporosis in a sample of Chinese men

Tao

Tang

et al. 2017

J Health Popul Nutr

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BackgroundThe main purpose of this study was to estimate the associations between frequency of fish food consumption and osteoporosis (OP) in general Chinese men.MethodsWe conducted a large-scale, community-based, cross-sectional study to investigate the associations by using self-report questionnaire to access frequency of fish food intake. A total of 1092 men were available for data analysis in this study. Multiple regression models controlling for confounding factors to include frequency of fish food consumption variable were performed to investigate the relationships for OP.ResultsPositive correlations between frequency of fish food consumption and T score were reported (β = 0.084, P value = 0.025). Multiple regression analysis indicated that the frequency of fish food consumption was significantly associated with OP (P < 0.05 for model 1 and model 2). The men with high frequency of fish food consumption had a lower prevalence of OP.ConclusionsThe findings indicated that frequency of fish food consumption was independently and significantly associated with OP. The prevalence of OP was less frequent in Chinese men preferring fish food habits.Trial registrationClinicalTrials.gov Identifier: NCT02451397 retrospectively registered 28 May 2015.

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“…However, it proved to be somewhat difficult to ‎estimate the direct effect of EPA, or its layer thickness, on bone growth (Damsgaard et al. ), something which could be addressed in the future research.…”

Section: Discussionmentioning

confidence: 99%

“…The radiographic investigations of this study found bone growth along EPA-coated surfaces, as highlighted in Figures 3 and 4. However, it proved to be somewhat difficult to estimate the direct effect of EPA, or its layer thickness, on bone growth (Damsgaard et al 2012), something which could be addressed in the future research.…”

Section: Discussionmentioning

confidence: 99%

EPA‐coated titanium implants promote osteoconduction in white New Zealand rabbits

Mustafa

Lung

Mustafa

et al. 2014

Clinical Oral Implants Res

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Objectives: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles.Material and methods: Sandblasted and cleansed planar titanium specimens with a size of 5 9 5 9 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The other side of the specimens was kept highly polished (the control side). These specimens were inserted in rabbit mandibles. Twelve rabbits were randomly assigned into three study groups (n = 4). The rabbits were sacrificed at 4, 8, and 12 weeks. The harvested specimens with the implants were assessed for new bone formation on both sides of the implant using CBCT, conventional radiographs, and the biaxial pullout test. The results were statistically analyzed by a nonparametric Kruskal-Wallis test and Friedman's test as multiple comparisons and by Brunner-Langer nonparametric mixed model approach (R Software).

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The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

Cited by 33 publications

References 37 publications

Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models

Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models

Analyzing the association between fish consumption and osteoporosis in a sample of Chinese men

EPA‐coated titanium implants promote osteoconduction in white New Zealand rabbits

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