The effects of neurochemical lesioning of dopaminergic terminals in early ontogenesis on behavior in adult rats

Shabanov, Petr D.; Lebedev, A. A.; Meshcherov, Sh. K.; Streltsov, V.F.

doi:10.1007/s11055-005-0089-y

Cited by 8 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, as experimental exposure began early in this study (5 dpf), at a time at which neurogenesis was still underway and the nervous system was maturing (Kastenhuber et al 2010, McGraw et al 2012, Souza & Tropepe 2011, the phenotypes observed may reflect this early disruption. Similar effects have been demonstrated following the embryonic disruption of monoamine systems (Dennis et al 2013, Shabanov et al 2005, Silva et al 2013 or early exposure to silver or cadmium (Kusch et al 2008, Powers et al 2011. Such a delayed effect has also been demonstrated in zebrafish, following the exposure of embryos or larvae to PAH mixtures (Vignet et al 2014a), in rat, after perinatal exposure (Crépeaux et al 2012) and after the exposure of Pacific herring embryos to weathered crude oil (Carls et al 1999).…”

Section: Discussionmentioning

confidence: 60%

Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior

Vignet

Ménach

Lyphout

et al. 2014

Environ Sci Pollut Res

View full text Add to dashboard Cite

In the last 10 years, behavior assessment has been developed as an indicator of neurotoxicity and an integrated indicator of physiological disruption. Polycyclic aromatic hydrocarbon (PAH) release into the environment has increased in recent decades resulting in high concentrations of these compounds in the sediment of contaminated areas. We evaluated the behavioral consequences of long-term chronic exposure to PAHs, by exposing zebrafish to diets spiked with three PAH fractions at environmentally relevant concentrations. Fish were exposed to these chemicals from their first meal (5 days postfertilization) until they became reproducing adults (at 6 months old). The fractions used were representative of PAHs of pyrolytic (PY) origin and of two oils differing in composition (a heavy fuel oil (HO) and a light crude oil (LO)). Several tests were carried out to evaluate circadian spontaneous swimming activity, responses to a challenge (photomotor response), exploratory tendencies, and anxiety levels. We found that dietary PAH exposure was associated with greater mobility, lower levels of exploratory activity, and higher levels of anxiety, particularly in fish exposed to the HO fraction and, to a lesser extent, the LO fraction. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can induce behavioral disruptions resulting in poorer fish performance.

show abstract

Section: Discussionmentioning

confidence: 60%

Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior

Vignet

Ménach

Lyphout

et al. 2014

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…This possibility is supported by a host of studies underscoring the key role of DA in behavioral disinhibition (Black et al , 2002; Megens et al , 1992; van Gaalen et al , 2006) and anxiolysis (Shabanov et al , 2005; Picazo et al , 2009). Previous studies have shown that PEA induces modification of the DA signaling, which may play a role in the behavioral responses mediated by this trace amine (Kuroki et al , 1990; Sotnikova et al , 2004).…”

Section: Discussionmentioning

confidence: 95%

Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice

Bortolato

Godar

Davarian

et al. 2009

Neuropsychopharmacol

View full text Add to dashboard Cite

Monoamine oxidase (MAO) B catalyzes the degradation of b-phenylethylamine (PEA), a trace amine neurotransmitter implicated in mood regulation. Although several studies have shown an association between low MAO B activity in platelets and behavioral disinhibition in humans, the nature of this relation remains undefined. To investigate the impact of MAO B deficiency on the emotional responses elicited by environmental cues, we tested MAO B knockout (KO) mice in a set of behavioral assays capturing different aspects of anxiety-related manifestations, such as the elevated plus maze, defensive withdrawal, marble burying, and hole board. Furthermore, MAO B KO mice were evaluated for their exploratory patterns in response to unfamiliar objects and risk-taking behaviors. In comparison with their wild-type (WT) littermates, MAO B KO mice exhibited significantly lower anxiety-like responses and shorter latency to engage in risk-taking behaviors and exploration of unfamiliar objects. To determine the neurobiological bases of the behavioral differences between WT and MAO B KO mice, we measured the brain-regional levels of PEA in both genotypes. Although PEA levels were significantly higher in all brain regions of MAO B KO in comparison with WT mice, the most remarkable increments were observed in the striatum and prefrontal cortex, two key regions for the regulation of behavioral disinhibition. However, no significant differences in transcript levels of PEA's selective receptor, trace amine-associated receptor 1 (TAAR1), were detected in either region. Taken together, these results suggest that MAO B deficiency may lead to behavioral disinhibition and decreased anxiety-like responses partially through regional increases of PEA levels.

show abstract

“…Shabanov et al . (2005) examined the effects of prenatal (days 13–17 of pregnancy) and early postnatal (days 4–10) systemic 6‐OHDA lesions in rats.…”

Section: Studies Examining the Effects Of Lesions (See Also Table 7)mentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

View full text Add to dashboard Cite

Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

show abstract

The effects of neurochemical lesioning of dopaminergic terminals in early ontogenesis on behavior in adult rats

Cited by 8 publications

References 6 publications

Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior

Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior

Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Contact Info

Product

Resources

About