The effects of neurotensin on selected parameters of lipid metabolism in rats

Piątek, Jacek; Witmanowski, Henryk; Paluszak, J; Krauss, Hanna; Krawczyk, Julia

doi:10.1016/j.peptides.2004.12.005

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…In the present study, pro-NT levels positively correlate with triglycerides concentration, which aligns with evidence from experimental models. NT administration was shown to directly modulate lipid metabolism in rats [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity

et al. 2018

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Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating precursor of NT, predict obesity, type 2 diabetes (T2D), and cardiovascular disease. In obesity, the presence of visceral adipose tissue (VAT) inflammation leads to unfavorable metabolic outcomes and is associated with the development of T2D and non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the relationship between plasma pro-NT levels and the presence of VAT inflammation in biopsies from 40 morbidly obese subjects undergoing bariatric surgery. We demonstrated that higher proNT levels are significantly associated with greater macrophages infiltration, HIF-1α, WISP-1, and UNC5B expression in VAT (all p < 0.01) due to the diagnosis of T2D and NAFLD. The overall results show that, in obesity, pro-NT is a biomarker of VAT inflammation and insulin-resistance. Additionally, NT may be involved in the development of dysmetabolic conditions likely mediated by increased gut fat absorption and the presence of a proinflammatory milieu in the adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity

et al. 2018

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“…Mechanisms behind the relationship between pro-NT and high CV risk remain partially unidentified. Based on ours and previous data, it can be speculated that NT contributes to the development of accumulating cardiometabolic risk factors by influencing food intake [ 14 – 16 ] and overall energy balance, though increased intestinal lipid absorption [ 11 , 12 , 21 ], altered glucose metabolism [ 15 , 16 , 18 , 22 ], adipose tissue homeostasis [ 19 ] and body fat distribution [ 22 ].…”

Section: Discussionmentioning

confidence: 97%

“…Besides, several pathophysiological mechanisms, partially overlapping those occurring in type 2 diabetes (T2D) and metabolic syndrome (MS), have been demonstrated in T1D [6,7]; among them, altered secretion pattern of gut peptide hormones, including amylin, ghrelin and glucosedependent insulinotropic polypeptide (GIP), was found also in T1D individuals [8,9]. Neurotensin (NT) is a gut hormone released by intestinal neuroendocrine cells in response to fat ingestion, facilitating fatty acids translocation through the intestinal mucosa [10][11][12]. NT also acts as a neurotransmitter by modulating the leptin-mediating food intake in the central nervous system [13,14].…”

Section: Introductionmentioning

confidence: 99%

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High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up

et al. 2021

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Aims Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile. Methods For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of Rome, Italy, collected at the baseline and after 10 years. Fasting plasma pro-NT levels were measured in T1D subjects at the baseline and in 34 age-, sex-, BMI-comparable healthy individuals recruited in the same period. Results Pro-NT did not differ significantly between patients and controls (median[range] pro-NT: 156.3 [96.6–198.2] vs. 179.4 [139.7–230.7] pmol/L, p = 0.26). In T1D, greater fasting pro-NT associated with poor glycemic control at baseline and predicted increased waist circumference, reduced insulin sensitivity, dyslipidemia and hypertension at 10-year follow-up. High pro-NT predicted 10-year very-high CV risk with adjusted OR = 11 (95%C.I.: 1.4–94.5; p = 0.029). Conclusions In T1D individuals, elevated pro-NT levels predict the development of adverse metabolic profile, which translates in higher CV risk profile at 10-year follow-up. Pro-NT represents a novel predictor/marker of CV risk factors in adults with T1D.

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“…NTS, which encodes a common precursor for peptides neuromedin N and neurotensin, participates in the regulation of fat metabolism in muscles [81,82]. A recent research confirmed its specific pathogenic role in the pathophysiology of RA [83].…”

Section: Discussionmentioning

confidence: 99%

Identifying Infliximab‐ (IFX‐) Responsive Blood Signatures for the Treatment of Rheumatoid Arthritis

Ding

Zeng

et al. 2021

BioMed Research International

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Rheumatoid arthritis (RA) is a severe chronic pathogenic inflammatory abnormality that damages small joints. Comprehensive diagnosis and treatment procedures for RA have been established because of its severe symptoms and relatively high morbidity. Medication and surgery are the two major therapeutic approaches. Infliximab (IFX) is a novel biological agent applied for the treatment of RA. IFX improves physical functions and benefits the achievement of clinical remission even under discontinuous medication. However, not all patients react to IFX, and distinguishing IFX-sensitive and IFX-resistant patients is quite difficult. Thus, how to predict the therapeutic effects of IFX on patients with RA is one of the urgent translational medicine problems in the clinical treatment of RA. In this study, we present a novel computational method for the identification of the applicable and substantial blood gene signatures of IFX sensitivity by liquid biopsy, which may assist in the establishment of a clinical drug sensitivity test standard for RA and contribute to the revelation of unique IFX-associated pharmacological mechanisms.

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The effects of neurotensin on selected parameters of lipid metabolism in rats

Cited by 7 publications

References 18 publications

Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity

Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity

High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up

Identifying Infliximab‐ (IFX‐) Responsive Blood Signatures for the Treatment of Rheumatoid Arthritis

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