The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats

Rinker, Jennifer A.; Busse, Gregory D.; Roma, Peter G.; Chen, Scott A.; Barr, Christina S.; Riley, Anthony L.

doi:10.1007/s00213-007-1050-2

Cited by 17 publications

(11 citation statements)

References 69 publications

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“…The 1.5 g/kg i.p. injection dose used in the current studies is within the 1.0-1.5 g/kg dose that causes taste aversions in adult rats (Liu et al 2009;Morales et al 2014;Rinker et al 2008). This decreased consumption effect is also similar to a strong and reliable decrease in voluntary alcohol consumption seen in another experiment from our laboratory, where alcohol injections were given at the end of the 24-h alcohol access period rather than the beginning (unpublished data).…”

Section: Alcohol Injections Caused High Spikes Of Blood Alcohol Levelsupporting

confidence: 80%

Prior alcohol consumption does not impair go/no-go discrimination learning, but causes over-responding on go trials, in rats

Pickens

Fisher

Bright

et al. 2016

Behavioural Brain Research

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Section: Alcohol Injections Caused High Spikes Of Blood Alcohol Levelsupporting

confidence: 80%

Prior alcohol consumption does not impair go/no-go discrimination learning, but causes over-responding on go trials, in rats

Pickens

Fisher

Bright

et al. 2016

Behavioural Brain Research

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“…Specifically, Cunningham and his colleagues have reported a direct relationship between the strength of aversions induced by alcohol and the degree of alcohol-induced hypothermia, i.e., the greater the alcohol-induced decrease in body temperature, the greater the strength of the aversion induced by alcohol. Consistent with this idea, the concurrent administration of nicotine and alcohol to naïve animals results in a significant decrease in rectal temperature and an increase in alcohol-induced taste aversions (Rinker et al , 2008). Although the present findings show that a history of nicotine during both periadolescence and early adulthood attenuates both alcohol-induced hypothermia and alcohol-induced taste aversions, the relationship was not absolute.…”

Section: Discussionmentioning

confidence: 72%

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Rinker

Hutchison

Chen

et al. 2011

Pharmacology Biochemistry and Behavior

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The majority of smokers begin their habit during adolescence, which often precedes experimentation with alcohol. Interestingly, very little preclinical work has been done examining how exposure to nicotine during periadolescence impacts the affective properties of alcohol in adulthood. Understanding how periadolescent nicotine exposure influences the aversive effects of alcohol might help to explain why it becomes more acceptable to this preexposed population. Thus, Experiment 1 exposed male Sprague Dawley rats to either saline or nicotine (0.4 mg/kg, IP) from postnatal day 34 to 43 (periadolescence) and then examined changes in the aversive effects of alcohol (0, 0.56, 1.0 and 1.8 g/kg, IP) in adulthood using the conditioned taste aversion (CTA) design. Changes in blood alcohol concentration (BAC) as well as alcohol-induced hypothermia and locomotor suppression were also assessed. To determine if changes seen were specific to nicotine exposure during periadolescence, the procedures were replicated in adults (Experiment 2). Preexposure to nicotine during periadolescence attenuated the acquisition of the alcohol-induced CTAs (at 1.0 g/kg) and the hypothermic effects of alcohol (1.0 g/kg). Adult nicotine preexposure produced similar attenuation in alcohol's aversive (at 1.8 g/kg) and hypothermic (1.8 g/kg) effects. Neither adolescent nor adult nicotine preexposure altered BACs or alcohol-induced locomotor suppression. These results suggest that nicotine can alter the aversive and physiological effects of alcohol, regardless of the age at which exposure occurs, possibly increasing its overall reinforcing value and making it more likely to be consumed.

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“…There is little evidence of a direct interaction between nicotine and alcohol in aversive or rewarding motivational measures as nicotine did not affect alcohol-induced conditioned taste aversions [67,68] and alcohol did not affect nicotine-induced CPP [67]; though nicotine and alcohol do cross-reinstate extinguished CPP [69]. Nicotine has been shown to attenuate alcohol-induced ataxia [70,71] suggesting that nicotine may attenuate some of the direct effects (e.g., motoric disruption) of higher alcohol doses (i.e., the descending limb of the dose-effect curve) allowing subjects to self-administer more drug.…”

Section: Nicotine + Alcohol Interactionsmentioning

confidence: 99%

Interactions between nicotine and drugs of abuse: a review of preclinical findings

Kohut

2016

The American Journal of Drug and Alcohol Abuse

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Polysubstance abuse is common among substance use disorder patients and nicotine is one of the most commonly co-used substances. Epidemiological and clinical laboratory studies suggest that nicotine, when combined with other drugs of abuse, increases intake of one or both substances. This review focuses on the preclinical literature regarding nicotine’s interaction with alcohol, stimulants (i.e., cocaine, amphetamines), opioids (i.e., morphine, heroin) and Δ9-tetrahydrocannabinol (THC). The current understanding of how these various classes of abused drugs may interact with nicotine on behavioral, physiological, and pharmacological indices that may be important in maintaining co-use of one or both substances in human populations are highlighted. Suggestions as to future areas of research and gaps in knowledge are offered.

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The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats

Cited by 17 publications

References 69 publications

Prior alcohol consumption does not impair go/no-go discrimination learning, but causes over-responding on go trials, in rats

Prior alcohol consumption does not impair go/no-go discrimination learning, but causes over-responding on go trials, in rats

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Interactions between nicotine and drugs of abuse: a review of preclinical findings

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