The Effects of Norepinephrine and Angiotensine on the Lymphatic System

Foldi, M; Zoltán, Ö.T.

doi:10.1159/000135849

Cited by 6 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hall, Morris &; Woolley (1965), for example, found that a 15 mmn infusion of adrenaline (50 jug min', a dose similar to that used in the present study) had no effect on thoracic duct pressure or lymph flow in sheep. Foldi & Zoltan (1966) found that noradrenaline depressed thoracic duct flow in the dog while adrenaline enhanced it. In contrast, DeMicheli & Glasser (1975) found that both adrenaline and noradrenaline increased canine thoracic duct flow, the latter being more potent.…”

Section: Discussionmentioning

confidence: 96%

The effect of intravenous adrenaline and noradrenaline infusion of peripheral lymph flow in the sheep.

McHale¹,

Roddie²

1983

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Pressure fluctuations and lymph flow were measured in popliteal, prefemoral and mesenteric efferent lymphatic vessels in conscious sheep.2. Intravenous adrenaline infusion increased frequency of lymphatic contraction and lymph flow in all three vessels. In the case of the prefemoral vessels flow remained high after the infusion had stopped.3. Intravenous noradrenaline infusion also increased frequency of contraction and lymph flow in all three vessels but prefemoral flow was depressed after the infusion had stopped.4. Lymphatic frequency of contraction and lymph flow increased when the animals were startled.5. Anaesthetizing the animals with pentobarbitone did not abolish lymphatic contractions, nor did it prevent the response to adrenaline and noradrenaline infusions.6. The most obvious interpretation of these results is that adrenaline and noradrenaline act by increasing frequency and force of pumping of lymphatic vessels.

show abstract

Section: Discussionmentioning

confidence: 96%

The effect of intravenous adrenaline and noradrenaline infusion of peripheral lymph flow in the sheep.

McHale¹,

Roddie²

1983

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…The peripheral sympathetic nervous system may modulate the flow of lymph in lymphatics, since autonomic innervation of thoracic ducts and other lymphatic channels has been demonstrated anatomically [2 71 and since epinephrine has been shown to be potent in increasing thoracic duct lymph flow [14]. The peripheral sympathetic nervous system may also regulate the number of lymphocytes in the general circulation; anxiety [13] and epinephrine injections [22] produce lymphocytosis in humans, and stress-induced lymphocytosis in cats can be prevented by sympathectomy [24].…”

mentioning

confidence: 99%

Lymph nodes—A possible site for sympathetic neuronal regulation of immune responses

Giron

Crutcher

Davis

1980

Annals of Neurology

138

View full text Add to dashboard Cite

Noradrenergic fibers were identified in rat cervical lymph nodes by fluorescence histochemistry and confirmed by radioenzymatic determination of norepinephrine. After superior cervical ganglionectomy, lymph node norepinephrine and noradrenergic fluorescence were strikingly decreased. The alpha-adrenergic radioligand [3H] dihydroergocryptine bound to saturable sites on lymph node membranes (0.20 pmol/mg protein; affinity constant, 8 nM) with characteristics expected for alpha-adrenergic receptor binding. The alpha-adrenergic binding sites were present in high concentration in membranes from lymph node stroma but were negligible in membranes of lymphocytes teased from nodes. In lymph nodes the ratio of alpha-adrenergic binding sites to norepinephrine content was higher than ratios of many other sympathetically innervated tissues such as iris or vas deferens. The presence of sympathetic innervation and the high concentration of alpha-adrenergic binding sites relative to that innervation suggest that the sympathetic nervous system modulates an intrinsic lymph node function through alpha-adrenergic mechanisms.

show abstract

“…The structures of 3-ethoxycarbonylethyl-7-hydroxy-4-methylcoumarin (4) and 3-ethoxycarbonylethyl-7-hydroxy-4, 8-dimethylcoumarin (5) has been determined from their 13 C-NMR spectra which showed a lactone carbonyl at (162.7 and an ester carbonyl at (173.2. In compound 4, they appeared at (162.6 and 173.7.…”

Section: Resultsmentioning

confidence: 99%

“…It is evident from the literature that the simple coumarins possess a diverse array of pharmacological and biochemical properties (2,5), some of which may be of potential pharmaceutical interest. It is also equally evident that their specificity of action is rather limited (7), in the sense that individual members of the coumarin family sometimes exert multiple actions, often within similar ranges of concentration.…”

Section: Introductionmentioning

confidence: 99%