The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review

Fakheran, Omid; Khademi, Abbasali; Bagherniya, Mohammad; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1007/978-3-030-73234-9_5

Cited by 9 publications

(5 citation statements)

References 118 publications

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“…Nutraceuticals are known for their health benefits: reduction of the risk of cancer and heart disease, but also the prevention or treatment of hypertension, hypercholesterolemia, overweight, osteoporosis, diabetes, arthritis, digestive disorders, and constipation, not to mention headaches [ 57 , 58 , 59 ]. It was shown that nutraceuticals may have therapeutic properties such as anti-inflammatory and antibacterial effects that may be beneficial for the treatment of periodontitis [ 60 ].…”

Section: Perspectivesmentioning

confidence: 99%

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Martin

Foulon

El‐Hage

et al. 2022

IJMS

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The study aimed to examine the impact of the oropharyngeal microbiome in the pathophysiology of schizophrenia and to clarify whether there might be a bidirectional link between the oral microbiota and the brain in a context of dysbiosis-related neuroinflammation. We selected nine articles including three systemic reviews with several articles from the same research team. Different themes emerged, which we grouped into 5 distinct parts concerning the oropharyngeal phageome, the oropharyngeal microbiome, the salivary microbiome and periodontal disease potentially associated with schizophrenia, and the impact of drugs on the microbiome and schizophrenia. We pointed out the presence of phageoma in patients suffering from schizophrenia and that periodontal disease reinforces the role of inflammation in the pathophysiology of schizophrenia. Moreover, saliva could be an interesting substrate to characterize the different stages of schizophrenia. However, the few studies we have on the subject are limited in scope, and some of them are the work of a single team. At this stage of knowledge, it is difficult to conclude on the existence of a bidirectional link between the brain and the oral microbiome. Future studies on the subject will clarify these questions that for the moment remain unresolved.

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Section: Perspectivesmentioning

confidence: 99%

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Martin

Foulon

El‐Hage

et al. 2022

IJMS

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“…The main source of periodontitis is bacteria and their elements, which can cause inflammation and subsequently damage the periodontium. When periodontitis occurs, ROS are produced, mostly by hyperactive neutrophils, and may not be balanced by the host antioxidant defense system, causing tissue damage; therefore, over the last few years, in support of the treatment of periodontitis, various biomaterials have been utilized as a contact inhibition membrane in guided tissue regeneration (GTR), which is the current gold standard clinical regeneration treatment [ 100 , 101 ]. Herein, some available antioxidant materials involved in the regeneration of the hard part of periodontal tissue (alveolar bone) have been reviewed.…”

Section: Role Of Antioxidant Materials In the Tissue Regeneration Pro...mentioning

confidence: 99%

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

et al. 2023

Self Cite

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Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts.

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“…Recently, natural products have shown many positive effects in the adjuvant therapy of periodontitis, 137–140 with the majority of them possessing exceptional anti-inflammatory, antioxidant, and bacteriostatic properties. Clinical studies 32 have shown that the subgingival delivery of 10% PEF gel as an adjunct to SRP in the treatment of chronic periodontitis can significantly improve the periodontal parameters of patients more effectively than SRP alone, including the plaque index (PI), gingival index (GI), modified sulcus bleeding index (mSBI), probing pocket dept (PPD), and clinical attachment level (CAL).…”

Section: Periodontitismentioning

confidence: 99%

Phyllanthus emblicafruits: a polyphenol-rich fruit with potential benefits for oral management

Li¹,

Yu²,

Zhang³

et al. 2023

Food Funct.

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The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review

Cited by 9 publications

References 118 publications

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature

Phyllanthus emblicafruits: a polyphenol-rich fruit with potential benefits for oral management

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