The effects of oral cadmium exposure on passive avoidance performance in the adult rat

Nation, Jack R.; Bourgeois, Anthony E.; Clark, Donald R.; Baker, Dorothy M.; Hare, Michael F.

doi:10.1016/0378-4274(84)90180-2

Cited by 28 publications

(5 citation statements)

References 9 publications

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“…Cadmium sulfate of 1 mg/kg rat was administered intramuscularly once daily for 4 months (long‐term treatment) (Rastogi et al 1977). Cadmium sulfate of 5 mg/kg rat and/or L‐cysteine 5 mg/kg rat were administered separately once, and after 8 hr the animals were sacrificed (short‐term treatment) (Nation et al 1984). Moreover, different CdSO 4 doses (1, 2 or 5 mg/kg rat) were administered in the short‐term treatment to better understand the nature of the observed changes in brain AChE, (Na + ,K + )‐ATPase and Mg 2+ ‐ATPase activities.…”

Section: Methodsmentioning

confidence: 99%

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine

Carageorgiou¹,

Tzotzes²,

Pantos³

et al. 2004

Basic Clin Pharma Tox

100

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This study was undertaken in order to investigate: a) the short-and long-term in vivo effects of cadmium (Cd) on brain acetylcholinesterase (AChE), (Na Brain total antioxidant status was decreased by Cd (30%, PϽ0.01), while it was increased by L-cysteine or L-cysteineπCd (50%, PϽ0.001) in the short-term in vivo treatment. L-cysteine reversed the enzymatic activity changes observed with Cd alone in the high-dose short-term in vivo treatment of rats, as well as the brain AChE inhibition induced by Cd in the in vitro experiments. These results indicate that: a) Cd can influence in a different way the examined enzyme activities after short-and long-term administration, b) Cd may modulate brain cholinergic mechanism(s), neural excitability and metabolic energy production, and c) L-cysteine can have a protective antioxidant effect on the oxidative stress of the brain induced by Cd.

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Section: Methodsmentioning

confidence: 99%

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine

Carageorgiou¹,

Tzotzes²,

Pantos³

et al. 2004

Basic Clin Pharma Tox

100

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“…Several animal studies have reported effects of cadmium on electrophysiological parameters, markers of neurotransmitter function, and neurobehavioral outcomes (Ali et al 1986; Desi et al 1998; Lehotzky et al 1990; Nagymajtenyi et al 1997; Nation et al 1983, 1984, 1989, 1990). Studies in children have reported associations between higher cadmium levels and mental retardation (Jiang et al 1990; Marlowe et al 1983), decreased verbal IQ (Thatcher et al 1982), lower neuropsychological test performance (Bonithon-Kopp et al 1986; Stellern et al 1983), learning disability (LD) (Capel et al 1981; Ely et al 1981; Pihl and Parkes 1977), poor reading performance (Thatcher et al 1984b), neurophysiological evoked potential differences (Thatcher et al 1984a), and behavioral problems in the presence of concurrently elevated lead levels (Marlowe et al 1985a).…”

mentioning

confidence: 99%

Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children

Ciesielski¹,

Weuve

Bellinger

et al. 2012

Environ Health Perspect

220

112

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Background: Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes.Objective: Our aim was to evaluate associations between urinary cadmium concentration and reported learning disability (LD), special education utilization, and attention deficit hyperactivity disorder (ADHD) in U.S. children using National Health and Nutrition Examination Survey (NHANES) data.Methods: We analyzed data from a subset of participants in NHANES (1999–2004) who were 6–15 years of age and had spot urine samples analyzed for cadmium. Outcomes were assessed by parent or proxy-respondent report. We fit multivariable-adjusted logistic regression models to estimate associations between urinary cadmium and the outcomes.Results: When we compared children in the highest quartile of urinary cadmium with those in the lowest quartile, odds ratios adjusted for several potential confounders were 3.21 [95% confidence interval (CI): 1.43, 7.17] for LD, 3.00 (95% CI: 1.12, 8.01) for special education, and 0.67 (95% CI: 0.28, 1.61) for ADHD. There were no significant interactions with sex, but associations with LD and special education were somewhat stronger in males, and the trend in the ADHD analysis was only evident among those with blood lead levels above the median.Conclusions: These findings suggest that children who have higher urinary cadmium concentrations may have increased risk of both LD and special education. Importantly, we observed these associations at exposure levels that were previously considered to be without adverse effects, and these levels are common among U.S. children.

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“…There are studies suggesting that Cd affects the GABA-ergic system (Nation et al, 1984). It was reported that Cd decreased GABA content in the prefrontal cortex (Esquifino et al, 2002), which might promote avoidance learning as a consequence of increased anxiety levels in animals (Nation et al, 1984).…”

Section: Discussionmentioning

confidence: 98%

The Influence of Intracerebral Streptozotocin and/or Cadmium on Memory Processes in Mice Exposed to Transient Cerebral Oligemia

Sałaga-Pylak

Pikuła

Wójtowicz-Chomicz

et al. 2010

Journal of Toxicology and Environmental Health, Part A

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The aim of the study was to examine the effects of simultaneous acute exposure to cadmium (Cd) and in the presence of streptozotozin (STZ) on the central nervous system (CNS) memory processes in mice subjected to transient brain ischemia. In order to obtain transient brain ischemia, operative occlusion of common carotid arteries for 30 min was performed. Cadmium chloride was administered intraperitoneally (ip) after the surgery at a single dose of 0.1 LD(50) (LD(50) = 14 mg/kg). Disturbances in glucose metabolism in the brain tissue were induced by bilateral intracerebral administration of STZ, a drug that inhibits the function of a neuronal insulin receptor. Long-term memory was evaluated by means of a step-through passive avoidance task. Spatial working memory expressed as spontaneous alternations was tested in the Y-maze test. Coexposure to brain oligemia and STZ on the CNS produced significant impairment of long-term memory processes in mice. An additional exposure to Cd exacerbated the deficits of these processes. These results indicate that brain oligemia, Cd, and altered glucose metabolism may aggravate adverse effects on memory.

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The effects of oral cadmium exposure on passive avoidance performance in the adult rat

Cited by 28 publications

References 9 publications

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine

Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children

The Influence of Intracerebral Streptozotocin and/or Cadmium on Memory Processes in Mice Exposed to Transient Cerebral Oligemia

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The effects of oral cadmium exposure on passive avoidance performance in the adult rat

Cited by 28 publications

References 9 publications

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na+,K+)‐ATPase and Mg2+‐ATPase Activities: Protection by L‐Cysteine

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na+,K+)‐ATPase and Mg2+‐ATPase Activities: Protection by L‐Cysteine

Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children

The Influence of Intracerebral Streptozotocin and/or Cadmium on Memory Processes in Mice Exposed to Transient Cerebral Oligemia

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In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine

In vivo and in vitro Effects of Cadmium on Adult Rat Brain Total Antioxidant Status, Acetylcholinesterase, (Na⁺,K⁺)‐ATPase and Mg²⁺‐ATPase Activities: Protection by L‐Cysteine