The effects of orbital frontal cortex damage on the modulation of defensive responses by rats in playful and nonplayful social contexts.

Pellis, Sergio M.; Hastings, Erica; Shimizu, Toshihisa; Kamitakahara, Holly; Komorowska, Joanna; Forgie, Margaret L.; Kolb, Bryan

doi:10.1037/0735-7044.120.1.72

Cited by 100 publications

(108 citation statements)

References 68 publications

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“…In keeping with these findings, the structure of social play and its sensitivity to social cues was found to be altered after neonatal lesions of the PFC or OFC (Bell et al, 2009;Panksepp et al, 1994;Pellis et al, 2006;Schneider and Koch, 2005).…”

Section: Introductionsupporting

confidence: 56%

“…Although the neural substrates of social play behavior are incompletely understood (Siviy and Panksepp, 2011;Trezza et al, 2010;Vanderschuren et al, 1997), there is evidence to support a role for the prefrontal cortex (PFC) and striatum in the regulation of social play behavior (Bell et al, 2009;Panksepp et al, 1994;Pellis et al, 1993Pellis et al, , 2006Schneider and Koch, 2005;Trezza et al, 2011Trezza et al, , 2012. As it is in these regions that profound neural changes occur during the juvenile and adolescent period (Casey and Jones, 2010;Crone and Dahl, 2012;Spear, 2000), the abundance of social play behavior suggests that play is related to the maturation of the PFC and striatum.…”

Section: Introductionmentioning

confidence: 99%

“…However, most of these studies used either indirect approaches (Cheng et al, 2008;Gordon et al, 2002;Van Kerkhof et al, 2013) or neonatal lesions (Bell et al, 2009;Panksepp et al, 1994;Pellis et al, 1993Pellis et al, , 2006Schneider and Koch, 2005), which may disrupt normal brain development and/or lead to compensatory changes in non-affected structures. Therefore, here we investigated the role of PFC and striatum subregions in social play behavior using a temporary pharmacological inactivation technique, which allows for transient disruption of functional activity but leaves normal brain development and function intact (Martin, 1991;McFarland and Kalivas, 2001;Van Duuren et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

Kerkhof

Damsteegt

Trezza

et al. 2013

Neuropsychopharmacol

140

118

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Social play behavior is a characteristic, vigorous form of social interaction in young mammals. It is highly rewarding and thought to be of major importance for social and cognitive development. The neural substrates of social play are incompletely understood, but there is evidence to support a role for the prefrontal cortex (PFC) and striatum in this behavior. Using pharmacological inactivation methods, ie, infusions of GABA receptor agonists (baclofen and muscimol; B&M) or the AMPA/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), we investigated the involvement of several subregions of the medial PFC and striatum in social play. Inactivation of the prelimbic cortex, infralimbic cortex, and medial/ventral orbitofrontal cortex using B&M markedly reduced frequency and duration of social play behavior. Local administration of DNQX into the dorsomedial striatum increased the frequency and duration of social play, whereas infusion of B&M tended to have the same effect. Inactivation of the nucleus accumbens (NAcc) core using B&M increased duration but not frequency of social play, whereas B&M infusion into the NAcc shell did not influence social play behavior. Thus, functional integrity of the medial PFC is important for the expression of social play behavior. Glutamatergic inputs into the dorsomedial striatum exert an inhibitory influence on social play, and functional activity in the NAcc core acts to limit the length of playful interactions. These results highlight the importance of prefrontal and striatal circuits implicated in cognitive control, decision making, behavioral inhibition, and reward-associated processes in social play behavior.

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

Kerkhof

Damsteegt

Trezza

et al. 2013

Neuropsychopharmacol

140

118

View full text Add to dashboard Cite

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“…The early research on RTP was done on nonhuman animals. The RTP of rats, hamsters, monkeys, and chimpanzees is fairly well-described [Chalmers, 1983;Paquette, 1994;Pellis, 1987, 1988] and studies have clearly established links between RTP and frontal-lobe functioning [Burgdorf et al, 2006;Panksepp et al, 2003;Pellis et al, 2005Pellis et al, , 2006 and socialization, particularly in primates [Hughes, 1991;Millar, 1968]. Although adults often confuse RTP with genuine aggression [Scott and Panksepp, 2003], research has clearly distinguished these two types of behaviors [Jones, 1972] and demonstrated that they arise from two distinct motivational systems, one associated with affiliation and the other with competition [Panksepp, 1998a;Paquette, 1994;Pellis et al, 2005].…”

Section: Play and Socializationmentioning

confidence: 99%

Rough‐and‐tumble play and the regulation of aggression: an observational study of father–child play dyads

Flanders

Leo

Paquette

et al. 2009

Aggressive Behavior

119

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Rough-and-tumble play (RTP) is a common form of play between fathers and children. It has been suggested that RTP can contribute to the development of selfregulation. This study addressed the hypothesis that the frequency of father-child RTP is related to the frequency of physically aggressive behavior in early childhood. This relationship was expected to be moderated by the dominance relationship between father and son during play. Eighty-five children between the ages of 2 and 6 years were videotaped during a free-play session with their fathers in their homes and questionnaire data was collected about father-child RTP frequency during the past year. The play dyads were rated for the degree to which the father dominated play interactions. A significant statistical interaction revealed that RTP frequency was associated with higher levels of physical aggression in children whose fathers were less dominant. These results indicate that RTP is indeed related to physical aggression, though this relationship is moderated by the degree to which the father is a dominant playmate.

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“…The parietal cortex has been shown to activate in self-interested economic decision making, especially expected utility calculations (14)(15)(16). Neural networks involved in social rewards also have been heavily researched (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Of particular interest to us is the orbitofrontal cortex (OFC), which is known to be reliably involved in social reward evaluation and decision making processes (15,17,19,(28)(29)(30)(31).…”

mentioning

confidence: 99%

Neural responses to sanction threats in two-party economic exchange

Xiao²,

Houser

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Sanctions are used ubiquitously to enforce obedience to social norms. However, recent field studies and laboratory experiments have demonstrated that cooperation is sometimes reduced when incentives meant to promote prosocial decisions are added to the environment. Although various explanations for this effect have been suggested, the neural foundations of the effect have not been fully explored. Using a modified trust game, we found that trustees reciprocate relatively less when facing sanction threats, and that the presence of sanctions significantly reduces trustee's brain activities involved in social reward valuation [in the ventromedial prefrontal cortex (VMPFC), lateral orbitofrontal cortex, and amygdala] while it simultaneously increases brain activities in the parietal cortex, which has been implicated in rational decision making. Moreover, we found that neural activity in a trustee's VMPFC area predicts her future level of cooperation under both sanction and no-sanction conditions, and that this predictive activity can be dynamically modulated by the presence of a sanction threat.cooperation ͉ neuroimaging ͉ perception shift ͉ punishment ͉ social norms S anctions are ubiquitous in modern human societies (1). The purpose of sanctions is to enforce norm obedience beyond the level that humans might achieve in the absence of punishment (2-4). However several recent field studies and laboratory experiments have established that adding monetary sanctions to an environment can reduce cooperation (5-7). Substantial speculation has arisen surrounding the source of this counterintuitive effect, including the possibility that the presence of sanctions might change individuals' perceptions of the environment, thus crowding out internal motivations for cooperation (5-8). The imposition of sanctions also might be perceived as a signal of distrust (9-11) and might create a hostile atmosphere (12, 13), leading to decreased cooperation.Previous behavioral experiments have sought to distinguish these competing explanations. For example, a recent study (5) reported data from an experiment aimed at determining the relative importance of intentions and incentives in producing noncooperative behavior. Participants played a one-shot investment experiment in pairs. Investors sent a certain amount to trustees, requested a return on that investment, and, in some treatments, could threaten sanctions to enforce their requests. Decisions by trustees facing threats imposed (or not) by investors were compared with decisions by trustees facing threats imposed (or not) by nature. The main finding was that when not threatened, trustees typically decided to return a positive amount less than the investor requested, but when threatened, that decision was less common. This result is the same whether the sanction is imposed by a human investor or by nature, suggesting that the detrimental effect of sanctions on cooperation might not hinge specifically on trustees' perceptions of investor intentions.

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The effects of orbital frontal cortex damage on the modulation of defensive responses by rats in playful and nonplayful social contexts.

Cited by 100 publications

References 68 publications

Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

Rough‐and‐tumble play and the regulation of aggression: an observational study of father–child play dyads

Neural responses to sanction threats in two-party economic exchange

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