The effects of partial sleep deprivation and the sub-maximal NDKS exercise testing protocol on S-Klotho and hemodynamic responses in women

Abstract

Purpose: The purpose of the study was to examine the influences of partial sleep deprivation on young healthy trained women's responses to the sub-maximal NDKS exercise testing protocol. Methods: 32females 20.4±1.67 years of age, volunteered to participate in this study. Subjects underwent two sub-maximal NDKS exercise tests, once after 7-8 hours of sleep, and once after staying awake for 20hours. S-Klotho, blood pressure, heart rate, fasting blood glucose, and lactate were obtained at baseline, immediate-post, and post a dynamic recovery of 15minutes. Results: S-Klotho at baseline was 422.09±32.62(pg•mL-¹). Significant differences were found between conditions regarding immediate-post S-Klotho concentration (547.18±51.75 vs 501.15±73.33 (pg•mL-¹), respectively, p ≤ 0.01). Significant differences were found between conditions regarding post-recovery S-Klotho concentration (443.31±35.66 vs 471.48±52.84(pg•mL-¹), respectively, p ≤ 0.01). Conclusion: While not all comparisons for data obtained were significantly different, subjects had impaired responses while partially sleep deprived. In addition, partial sleep deprivation influenced S-Klotho concentrations for the worst while compared to non-sleep deprivation.