Purpose: The purpose of the study was to examine the influences of partial sleep deprivation on young healthy trained women's responses to the sub-maximal NDKS exercise testing protocol. Methods: 32females 20.4±1.67 years of age, volunteered to participate in this study. Subjects underwent two sub-maximal NDKS exercise tests, once after 7-8 hours of sleep, and once after staying awake for 20hours. S-Klotho, blood pressure, heart rate, fasting blood glucose, and lactate were obtained at baseline, immediate-post, and post a dynamic recovery of 15minutes. Results: S-Klotho at baseline was 422.09±32.62(pg•mL-¹). Significant differences were found between conditions regarding immediate-post S-Klotho concentration (547.18±51.75 vs 501.15±73.33 (pg•mL-¹), respectively, p ≤ 0.01). Significant differences were found between conditions regarding post-recovery S-Klotho concentration (443.31±35.66 vs 471.48±52.84(pg•mL-¹), respectively, p ≤ 0.01). Conclusion: While not all comparisons for data obtained were significantly different, subjects had impaired responses while partially sleep deprived. In addition, partial sleep deprivation influenced S-Klotho concentrations for the worst while compared to non-sleep deprivation.

Purpose: The purpose of the study was to examine the influences of partial sleep deprivation on young healthy trained men's responses to the maximal NDKS exercise testing protocol. Methods: 33 males 21.2±2.31 years of age, volunteered to participate in this study. Subjects underwent two maximal NDKS exercise tests, once after 7-8hours of sleep, and once after staying awake for 20hours. S-Klotho, blood pressure, and heart rate were obtained at baseline, immediate-post, and post a dynamic recovery of 15minutes. Oxygen uptake was measured throughout exercise. Results: Significant differences were found between S-Klotho values at baseline and immediate-post of PSD and NPSD (463.31±64.18vs 651.17±70.81 pg•mL-¹, F(1,65) = 33.45, p = 0.01 and 463.31±64.18vs 727.14±81.3 pg•mL-¹, F(1,65) = 38.06, p = 0.01 respectively). Significant differences were found between conditions regarding PSD immediate-post S-Klotho concentration and that of NPSD (651.17±70.81 vs 727.14±80.3 pg•mL-¹, respectively, F(1,65) = 14.648, p = 0.02). Significant differences were found between conditions regarding baselinepost-recovery S-Klotho concentration and PSD(463.31±64.18 vs 522.68±51.98 pg•mL-¹, respectively, F(1,65) = 12.96, p-0.03). Significant differences were found between immediate-post S-Klotho values and postrecovery (PSD: 651.17±70.81 vs 522.68±51.98 pg•mL-¹, F(1,65) = 31.2, p = 0.03) and (NPSD: 727.14±80.3 vs 513.41±55.24 pg•mL-¹, F(1,65) = 34.2, p = 0.02). Conclusion: Partial sleep deprivation induced multiple negative significant differences in S-Klotho concentrations and in some cases, hemodynamic responses as well. Oxygen uptake was significantly lower while partially sleep deprived.