The effects of passive smoking on the human placenta: A gross and microscopic study

Sreenivasan, Srividya; Khare, Satyam

doi:10.4103/jasi.jasi_5_19

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“…These morphological changes are similar to those of apoptosis, known as programmed cell death [18]. In similar studies, the increase in the number of apoptotic nuclei in trophoblasts of patients with preeclampsia has been pointed out [19][20][21]. Rath et al [22] reported that trophoblastic basement membrane thickening was associated with preeclampsia and HELLP.…”

Section: Discussionmentioning

confidence: 67%

Severe Pre-Eclampsia Complicated by Hellp Syndrome in the Hoffbauer and Syncytiotrophoblast Cells (Ultrastructural and Immunohistochemical Study)

Nergız

ÖZTÜRK

Aşır

et al. 2022

Middle East Journal of Science

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The aim of this study was to evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblast and Hoffbauer cells in placental villi of HELLP syndrome patients. Placental samples with twenty control (normotensive) and twenty HELLP syndrome were fixed in 10% neutral formalin solution for paraffin-embedding wax protocol. Placental samples were fixed in 2.5% buffered glutaraldehyde and then, in 1% osmium tetra oxide for routine electron microscopic procedure. When the HELLP group fetal placental sections were examined, intracytoplasmic edema in syncytiotrophoblast, degenerative vacuoles and degenerative findings on cell surface membranes were observed. Moreover, villous edema was remarkable. The number of CD68 positive Hoffbauer cells per villus control group sections was 0.23 ± 0.02 and the number of CD68 positive cells per villus in HELLP group placenta sections was 0.83 ± 0.12 . The increase in the number of Hoffbauer cells per villus in the HELLP group was statistically significant (p

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