“…In a study from South Carolina, levels of care were defined by both, availability of medical speciality and subspeciality care as well as by volume of annual deliveries (Level III ‡ 1,500 annual deliveries), and lower neonatal mortality and shorter hospital stays among VLBW-neonates were reported for Level III centres [1]. Third, minimal caseload/ volume criteria for NICUs are often linked to a specific subpopulation at risk, such as gestational age \32 weeks [27], or birthweight 500-1,499 g [1,6,21,28], based on the concept that neonates being at highest risk will benefit most from centralised perinatal care. In contrast, previous studies on the impact of obstetrical volume and perinatal outcome referenced to all deliveries [4,11,25,26].…”