The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor-bearing mice

Akiyama, Yasuyuki; Mori, Takeshi; Katayama, Yoshiki; Niidome, Takuro

doi:10.1016/j.jconrel.2009.06.006

Cited by 193 publications

(167 citation statements)

References 24 publications

Supporting

Mentioning

159

Contrasting

Order By: Relevance

“…Importantly, the diameter of the particles should not be more than 100 nm to avoid opsonisation and subsequent elimination of the immune system [23][24][25][26]. The advantages of using Ag and Au nanoscale particles for drug delivery applicationinclude the ability of these structures to:…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System

Lah¹,

Samykano²,

Trigueros³

2016

JNMR

View full text Add to dashboard Cite

In the recent years, noble metal particles such as gold (Au) and silver (Ag) have been used progressively as efficient and safe nanoscale drug carriers in treating malignant as cites of cancerous cells. These single crystal structures of functionalised therapeutic particles with the size less than 100 nm in diameter had proven offered an excellent function to modulate the oxidative stress and toxicity at affected membrane cells particularly to achieve the site-specific delivery of drugs. This mini-review will highlight the current advances of Au and Ag nanoscale particles as smart chemotherapeutic molecule carriers to these malignancies in impeding cancer cell activities locally. The paper also reviewed valuable insights of their efficacy in maintaining and precisely control the drugs release level within the therapeutic windows.

show abstract

Section: Introductionmentioning

confidence: 99%

Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System

Lah¹,

Samykano²,

Trigueros³

2016

JNMR

View full text Add to dashboard Cite

show abstract

“…In this study, surface grafting with PEG:Au molar ratio of 1.5 showed the most prolonged blood circulation, and thus demonstrated increased tumor-targeting ability with decreased liver and spleen accumulation. 47 Surface charge and size contribution for biodistribution…”

mentioning

confidence: 99%

Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency

Kim¹,

Khang²

2015

IJN

View full text Add to dashboard Cite

Over the past 60 years, numerous medical strategies have been employed to overcome neoplasms. In fact, with the exception of lung, bronchial, and pancreatic cancers, the 5-year survival rate of most cancers currently exceeds 70%. However, the quality of life of patients during chemotherapy remains unsatisfactory despite the increase in survival rate. The side effects of current chemotherapies stem from poor target efficiency at tumor sites due to the uncontrolled biodistribution of anticancer agents (ie, conventional or current approved nanodrugs). This review discusses the effective physiochemical factors for determining biodistribution of nanocarriers and, ultimately, increasing tumor-targeting probability by avoiding the reticuloendothelial system. Second, stem cell-conjugated nanotherapeutics was addressed to maximize the tumor searching ability and to inhibit tumor growth. Lastly, physicochemical material properties of anticancer nanodrugs were discussed for targeting cellular organelles with modulation of drug-release time. A better understanding of suggested topics will increase the tumor-targeting ability of anticancer drugs and, ultimately, promote the quality of life of cancer patients during chemotherapy.

show abstract

“…It is known that nanorods localized in tumor tissues, 14 but distribution of nanoparticles in tumor tissues have not been clarified. Here, we attempted to use IMS of tumortissue sections to visualize their distributions within the tissues.…”

mentioning

confidence: 99%

“…At 72 h after the injection, most injected gold nanorods were not found in the blood flow, but were localized within the liver and tumor tissues. 13,14 Figure 1(d+f) indicates that gold nanorods were localized in the vasculature-rich regions that had a reddish color, even at 72 h after the injection.…”

mentioning

confidence: 99%