The effects of perfluoro-n-decanoic acid (PFDA) on rat heart ?-receptors, adenylate cyclase, and fatty acid composition*1

Pilcher, Gary D.; Gutshall, Denise M.; Langley, Albert E.

doi:10.1016/0041-008x(87)90327-9

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…The toxic potency of PFDA is quite high, with an LD 50 4.6-fold lower than that estimated for PFOA (Olson and Andersen, 1983). PFDA has also been reported to produce hepatotoxicity, anorexia, alteration of fatty acid metabolism, reduction of circulating thyroid hormones and androgen, bradycardia, and hypothermia in the rat (Bookstaff et al, 1990;George and Andersen, 1986;Gutshall et al, 1988Gutshall et al, , 1989Langley and Pilcher, 1985;Pilcher and Langley, 1986;Pilcher et al, 1987;Singer et al, 1990).…”

Section: Toxicity Of Other Perfluoroalkyl Acidsmentioning

confidence: 89%

The developmental toxicity of perfluoroalkyl acids and their derivatives

Lau

Butenhoff²,

Rogers

2004

Toxicology and Applied Pharmacology

767

480

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Perfluoroalkyl acids such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have applications in numerous industrial and consumer products. Although the toxicology of some of these compounds has been investigated in the past, the widespread prevalence of PFOS and PFOA in humans, as demonstrated in recent bio-monitoring studies, has drawn considerable interest from the public and regulatory agencies as well as renewed efforts to better understand the hazards that may be inherent in these compounds. This review provides a brief overview of the perfluoroalkyl chemicals and a summary of the available information on the developmental toxicity of the eight-carbon compounds, PFOS and PFOA. Although the teratological potentials of some of these chemicals had been studied in the past and the findings were generally unremarkable, results from recent postnatal studies on developmental and reproductive indices have prompted consideration of their relevance to human health risk. Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals.

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Section: Toxicity Of Other Perfluoroalkyl Acidsmentioning

confidence: 89%

The developmental toxicity of perfluoroalkyl acids and their derivatives

Lau

Butenhoff²,

Rogers

2004

Toxicology and Applied Pharmacology

767

480

View full text Add to dashboard Cite

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Effects on Rodents of Perfluorofatty Acids

DePierre

The Handbook of Environmental Chemistry

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Perfluorodecanoic acid decreases the enzyme activity and the amount of glutathione S-transferases proteins and mRNAs in vivo

Schramm¹

1989

Chemico-Biological Interactions

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The weak interaction plays a critical role in modern Big Bang cosmology. This review will emphasize two of its most publicized cosmological connections: (1) Big Bang nucleosynthesis and (2) Dark Matter. The first of these is connected to the cosmological prediction of of Neutrino Flavours, N, N 3 which is now being confirmed at SLC and LEP. The second is interrelated to the whole problem of galaxy and structure formation in the universe. This review will demonstate the role of the weak interaction both for dark matter candidates and for the problem of generating seeds to form structure.

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The effects of perfluoro-n-decanoic acid (PFDA) on rat heart ?-receptors, adenylate cyclase, and fatty acid composition*1

Cited by 8 publications

References 25 publications

The developmental toxicity of perfluoroalkyl acids and their derivatives

The developmental toxicity of perfluoroalkyl acids and their derivatives

Effects on Rodents of Perfluorofatty Acids

Perfluorodecanoic acid decreases the enzyme activity and the amount of glutathione S-transferases proteins and mRNAs in vivo

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