The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index

Purwar, Parth; Khan, Mohammed Akhlaq; Gupta, Abhishek; Mahdi, Abbas Ali; Pandey, Sushil; Singh, Babita; Dixit, Jaya; Rai, Priya

doi:10.3109/00016357.2015.1030768

Cited by 9 publications

(12 citation statements)

References 43 publications

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“…Further, the Galbraith plots showed that the studies performed by Shi et al, Purwar et al, Mendoza-Azpur et al, Thanakun et al, and Karthikeyan et al (L1) [30, 31, 49, 51, 52]; Mendoza-Azpur et al and Sete et al (A1) [16, 31]; and Purwar et al (L2) [57] were located outside of the two lines in the Galbraith plots of the subgroups of BMI <30. After removing the outliers, the heterogeneities effectively decreased, and the results were not materially changed in the subgroups of BMI <30 (L1: SMD = 0.796, 95% CI: 0.572–1.020, P = 0.000; I 2 = 40.9, P = 0.095; A1: SMD = −0.251, 95% CI: −0.408 to −0.095, P = 0.002; I 2 = 13.6, P = 0.323; L2: SMD = −0.162, 95% CI: −0.417 to 0.094, P = 0.215; I 2 = 0.0, P = 0.556).…”

Section: Resultsmentioning

confidence: 99%

“…Besides this, nine clinical trials detecting the serum levels of leptin and adiponectin in patients with periodontitis before and after periodontal treatments were included [28, 29, 39, 54–59]. The clinical trials performed by Duzagac et al, Purwar et al, and Shimada et al also enrolled the periodontally healthy groups and provided the pretherapy data on the serum levels of leptin and adiponectin in patients with periodontitis and healthy individuals [54, 57, 58]. The studies performed by Altayet al, Duzagacet al, Goncalveset al, Mendoza-Azpuret al, and Zimmermann et al provided the data on subjects with BMI <30 and BMI ≥30 separately [31, 32, 39, 54–56], and the study performed by Zeigler et al provided only the data on obesity subjects.…”

Section: Resultsmentioning

confidence: 99%

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Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

et al. 2017

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BackgroundThis study aimed to assess the difference in serum levels of leptin and adiponectin in patients with periodontitis and in periodontally healthy individuals and evaluate the changes in circulating leptin and adiponectin after periodontal therapy. Leptin and adiponectin are the most generally studied adipokines that function as inflammatory cytokines. Although the association between periodontitis and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent.MethodsA systematic search of the Pubmed, Embase, Web of Science, and Cochrane Library up to September 2016 was conducted. The studies were screened and selected by two writers according to the specific eligibility criteria. The quality of included cross-sectional studies was assessed using the quality assessment form recommended by the Agency for Healthcare Research and Quality and Methodological Index for Nonrandomized Studies. The meta-analyses were conducted using the STATA 12.0 software.ResultsA total of 399 manuscripts were yielded and 25 studies were included in the present meta-analysis. Significantly elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis were observed in the subgroup analysis of body mass index (BMI) <30. The overall and subgroup analyses showed no significant change in the serum levels of leptin in patients with periodontitis after periodontal treatment. The subgroup analysis of systemically healthy patients showed no significant change in serum levels of adiponectin in patients with periodontitis after periodontal treatment.ConclusionsThe present meta-analysis supported elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis compared with controls in the BMI <30 population. In systemically healthy patients with periodontitis, serum levels of leptin and adiponectin do not significantly change after periodontal treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

et al. 2017

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“…In the two Purwar studies [20,21] and the Karthikeyan study [18], CP was defined for each patient by plaque index, gingival index, pocket depth, and clinical level of periodontal attachment that were scored on six sites (mesiovestibular, vestibular, distovestibular, mesiolingual, lingual, and distolingual) in each tooth, excluding the third molar, and the presence of bleeding during probing was evaluated using a sterile periodontal probe. All clinical parameters were recorded by one independent person.…”

Section: Description Of Selected Studies For Quantitative Analysismentioning

confidence: 99%

“…The diagnosis of CP was established on the basis of clinical findings of gingival inflammation, clinical loss of periodontal attachment of >5 mm for Purwar [20,21] and only >1 mm for Karthikeyan [19], pocket depth of ≥4 mm in 3-4 sites in >4 teeth in each quadrant, and radiographic evidence of bone loss.…”

Section: Description Of Selected Studies For Quantitative Analysismentioning

confidence: 99%

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Analysis of leptin concentrations in oral fluids (saliva and crevicular gingival fluid) and blood in patients with chronic periodontal disease: systematic review of literature

Caillet

Mignan

Dang

et al. 2020

J Oral Med Oral Surg

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Objective: The objective of this systematic analysis was to perform a qualitative and quantitative synthesis of the literature concerning salivary and serum leptin variations in patients with chronic periodontitis (CP) compared with healthy subjects. Saliva leptin concentration analysis could be a relevant and non-invasive biological test for the evaluation of periodontal disease in both medical and clinical trials, beyond the clinical and radiographic elements. Material and Method: Querying the PubMed and Web of Science databases identified articles that met our inclusion criteria. Quantitative analysis of the literature data was performed with the Review Manager 5.3 software. Results: The qualitative analysis included 14 articles and showed a decrease of salivary leptin (5 studies out of 5) and an increase of serum leptin (11 of 12 studies) in patients with CP compared to unaffected subjects of CP. Quantitative analysis was performed on 4 trials. For salivary leptin, we confirmed a decrease in its level in patients with CP with a standardized mean difference (SMD) of −2.27, 95% CI [−2.68, −1.86]. The difference was highly significant but we detected a very important heterogeneity in this dataset (I2 = 94%). For serum leptin, we also confirmed an increase in its rate in patients with CP with an SMD of 2.18, 95% CI [1.75, 2.61]. The difference was highly significant but the heterogeneity measured in this dataset was also too high (I2 = 95%). Conclusion: The current level of evidence was insufficient to assert an increase in serum leptin and a decrease in salivary leptin in CP patients compared to healthy controls due to a great heterogeneity of the values measured in the studies.

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Impact of non-surgical periodontal treatment on salivary expression of cytokines related to bone metabolism

et al. 2020

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The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index

Abstract: Altered concentrations of leptin in serum and saliva are observed in CP patients which can be restored in favor of health after periodontal therapy.

Cited by 9 publications

References 43 publications

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Analysis of leptin concentrations in oral fluids (saliva and crevicular gingival fluid) and blood in patients with chronic periodontal disease: systematic review of literature

Impact of non-surgical periodontal treatment on salivary expression of cytokines related to bone metabolism

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