The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients

Abstract

The periodontal health of 30 adult epileptic patients treated with either sodium valproate or phenytoin was compared with a control group (n = 15) of otherwise healthy patients. The 3 groups were matched for age and sex. Patients on phenytoin therapy showed significantly higher plaque scores (P less than 0.05), gingival index (P less than 0.05) and pocketing (P less than 0.05) than patients in the control group. The % of gingival hyperplasia was significantly higher (P less than 0.05) in the phenytoin-treated patients than those on sodium valproate or in the control group. However, patients on phenytoin therapy had significantly less bone loss than those on sodium valproate (P less than 0.05) or in the control group (P less than 0.01). No significant differences were observed between the sodium valproate group and the control group on any of the parameters assessed. The results from this study would suggest that sodium valproate has no unwanted effects on periodontal health and may be considered a safe alternative, regarding the periodontal aspects, to phenytoin for the treatment of adult onset epilepsy.

Prevalence and Risk of Gingival Enlargement in Patients Treated With Nifedipine

“…The following grades were scored in 6 points around each tooth: grade 0, normal gingiva; 1, minimal enlargement (≤2 mm in size, with gingiva covering the cervical third or less of the anatomic crown); 2, moderate enlargement (2 to 4 mm in size and/or gingiva extending into the middle third of the anatomic crown); and 3, severe enlargement (nodular growth >4 mm and/or gingiva covering more than two-thirds of the tooth crown). Gingival overgrowth was also measured in the buccal-lingual direction in all interdental papilla according to the index described by Seymour et al 57 and modified by Miranda et al (MB index). 58 The increase in size of the papilla was measured from the enamel surface, at the interdental contact point, to the outer papillary surface.…”

İlaca Bağli Di̇şeti̇ Büyümesi̇ İki̇ Vaka Sunumu

“…Tedavi öncesi görünüm Seymour ve ark. 'nın 12 hiperplazi indeksi değerlerine göre hastanın dişetleri skor 2 olarak belirlendi. Hastanın oral hijyeni iyi olmamasına rağmen supra ve subgingival diş taşları pek fazla gözlenmedi.…”

Hereditary Gingival Fibromatosis: Report of Two Cases

“…[16][17][18] BPT dâ hi lin de ağız hij ye ni eği ti mi ve ril di, diş yü zeyi te miz li ği ve kök yü ze yi düz leş tir me si iş lem le ri uy gu lan dı. BPT son ra sı dört haf ta lık iyi leş me sü resi bek len dik ten son ra cer ra hi pe ri o don tal te da vi ye ge çil di (Resim 2a, b).…”