The effects of physical therapy with neuromuscular electrical stimulation in patients with septic shock

Lago, Alessandra Fabiane; Oliveira, Anamaria Siriani de; Souza, Hugo Celso Dutra de; Silva, João; Basile-Filho, Aníbal; Gastaldi, Ada Clarice

doi:10.1097/md.0000000000009736

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…Sepsis has been identified as a systemic inflammatory response to infection or injury (1). About 50% of sepsis patients require intensive care unit treatment (2,3), leading to high morbidity and mortality (4,5). The annual incidence of severe sepsis is increasing, with a recent report showing 132 cases of patients per 100,000 people, a mortality rate of nearly 50%, and the high financial burden of $50,000 per patient for nursing care (6,7).…”

Section: Introductionmentioning

confidence: 99%

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Sun

Luan

Guo

et al. 2020

Braz J Med Biol Res

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Section: Introductionmentioning

confidence: 99%

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Sun

Luan

Guo

et al. 2020

Braz J Med Biol Res

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“…Registered onJune 5, 2017 and November 13, 2018 https://clinicaltrials.gov/ ). The protocol was published previously [ 13 ]. The data were collected in an ICU of a Brazilian University Hospital from November 2018 to January 2020.…”

Section: Methodsmentioning

confidence: 99%

Effects of physical therapy with neuromuscular electrical stimulation in acute and late septic shock patients: A randomised crossover clinical trial

et al. 2022

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Background Patients with sepsis and immobility in the intensive care unit are associated with muscle weakness, and early mobilisation can counteract it. However, during septic shock, mobilisation is often delayed due to the severity of the illness. Neuromuscular electrical stimulation (NMES) may be an alternative to mobilise these patients early. This study aims to identify whether NMES performed within the first 72 hours of septic shock diagnosis or later is safe from a metabolic perspective. Methods This is the analysis of two randomised controlled crossover studies. Patients with acute septic shock (within the first 72 hours of diagnosis) and sepsis and septic shock in the late phase (after 72 hours of diagnosis) were eligible. Patients were submitted in a random order to the intervention protocol (dorsal decubitus position with the lower limbs raised and NMES) and control (dorsal decubitus position with the lower limbs raised without NMES). The patients were allocated in group 1 (intervention and control) or group 2 (control and intervention) with a wash-out period of 4 to 6 hours. Metabolic variables were evaluated by indirect calorimetry. Results Sixteen patients were analysed in the acute septic shock study and 21 in the late sepsis/septic shock study. There were no significant differences between Oxygen Consumption (VO2) values in the acute phase of septic shock when the baseline period, intervention, and control protocols were compared (186.59 ± 46.10; 183.64 ± 41.39; 188.97 ± 44.88, p>0.05- expressed in mL/Kg/min). The same was observed when the VO2 values in the late phase were compared (224.22 ± 53.09; 226.20 ± 49.64; 226.79 ± 58.25, p>0.05). The other metabolic variables followed the same pattern, with no significant differences between the protocols. When metabolic variables were compared between acute to late phase, significant differences were observed (p<0.05). Conclusions As metabolic rates in septic shock patients had no increase during NMES, either in the first 72 hours of diagnosis or later, NMES can be considered safe from a metabolic viewpoint, even despite the higher metabolic demand in the acute phase of shock. Trial registration NCT03193164; NCT03815994. Registered on June 5, 2017; November 13, 2018 (clinicaltrials.gov/).

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“…A randomized, controlled clinical trial is underway to elucidate the possible beneficial effects of NMES, evaluated by the mobilization of ESC in patients with septic shock. This study will explore the potential use of NMES as a preventive and rehabilitative tool in critical patients in septic shock [30].…”

Section: Parameters Of Nmes and Effects On Microcirculationmentioning

confidence: 99%

Neuromuscular Electrical Stimulation in Intensive Care Unit Patients: Integrative Review

Baron¹,

Pinto²,

Koepp³

et al. 2019

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Intensive care units' acquired muscle weakness is present in approximately 50% of the patients. Although active muscle training can attenuate weakness, a large proportion of critical patients cannot participate in any active mobilization. Neuromuscular electrical stimulation may be an alternative strategy to reverse muscle weakness. The objective of the study was to review the scientific publications on the use of neuromuscular electrical stimulation and its parameters and the main results in patients hospitalized in intensive care units. This is an integrative review surveying studies in online databases. The studies were selected from the following descriptors: neuromuscular electrical stimulation AND parameters AND intensive care units AND muscle weakness. The inclusion criteria included articles that addressed the topic of neuromuscular electrical stimulation and the parameters used in patients admitted to intensive care units, aged 18 years or older. Exclusion criteria were studies involving animals, case reports, letters to the editor and book chapters. The search comprised articles in the Portuguese, English and Spanish languages from

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The effects of physical therapy with neuromuscular electrical stimulation in patients with septic shock

Cited by 13 publications

References 34 publications

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Effects of physical therapy with neuromuscular electrical stimulation in acute and late septic shock patients: A randomised crossover clinical trial

Neuromuscular Electrical Stimulation in Intensive Care Unit Patients: Integrative Review

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