The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications

Fenercioğlu, Ayşen Kutan; Saler, Tayyibe; Genç, Ece; Sabuncu, Hilmi; Altuntaş, Yüksel

doi:10.1007/bf03346565

Cited by 112 publications

(78 citation statements)

References 22 publications

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“…All other chemicals used were of analytical grade. "moderate correlation"; 0.60-0.79 "strong correlation"; 0.80-1.0 "very strong correlation", as mentioned in other research studies (Fenercioglu et al, 2010;Floegela et al, 2011;Harris et al, 2011).…”

Section: Reagentssupporting

confidence: 51%

Assay of Antioxidant Capacity and Phenolic Compounds in some Romanian and Cypriot Wine

Luchian

Colibaba

Codreanu

et al. 2018

Not Bot Horti Agrobo

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Free radicals have an important role in food and in chemical material degradation, contributing to the occurrence of many human health problems, but the antioxidants can considerably delay or prevent the oxidation of easily oxidable substrates. The present research aimed to assess the antioxidant activity, expressed by the presence of polyphenols, flavonols, flavones, anthocyanidins and flavanols, in several Romanian and Cypriot wines. The wine phenolics content was analysed by highperformance liquid chromatograph (HPLC) Shimadzu equipped with two chromatographic columns. Higher concentrations were registered in all red wines. The antioxidant activity quantification was carried out by the DPPH method, a simple and cheap approach based on the absorbance decrease determination of the DPPH radical (2,2-diphenyl-1-picrylhydrazyl) in the presence of antioxidants. The highest antioxidant activity for white wines was determined at 'Spouriko' for Cypriot wine from 2013 (EC 50 = 1/38) while for Romanian wines, the highest value was found in a 'Tămâioasă românească' (EC50 = 1/58) and for red wines at 'Maratheftiko' wine from 2012 (EC50 = 1/680) and in 'Fetească Neagră' wine from 2014 (EC50 =1/590). This study provides relevant information to consumers and industry alike regarding the beneficial role wine plays for human health. It also can act as a baseline for choosing a certain product, according to its sanogenic potential.

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Section: Reagentssupporting

confidence: 51%

Assay of Antioxidant Capacity and Phenolic Compounds in some Romanian and Cypriot Wine

Luchian

Colibaba

Codreanu

et al. 2018

Not Bot Horti Agrobo

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“…A possible mechanism of decreasing oxidative damage in cells by garlic extracts is by preventing lipid peroxidation (Fenercioglu et al, 2010). In the present study, the extracts demonstrated a high antioxidant activity against hydrolytic rancidity of crude palm oil in a concentration dependent manner.…”

Section: Discussionsupporting

confidence: 55%

Determination of in vitro Antioxidant and Radical Scavenging Activities of Different Extracts of Allium sativum (Garlic)

Dandare¹,

Ezeonwumelu²,

Ezeh³

et al. 2014

IOSRJPBS

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“…Therefore, development of targeted therapeutics is needed in order to ameliorate or eliminate diabetes associated kidney damage. In both experimental and clinical models of diabetes, antioxidants have been reported to reduce markers of oxidative stress [12,13]. Besides, some studies have showed that antioxidants are effective and cheaper than conventional therapy in management of some diseases [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

Daniel¹

2015

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Abstract:The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.

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The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications

Cited by 112 publications

References 22 publications

Assay of Antioxidant Capacity and Phenolic Compounds in some Romanian and Cypriot Wine

Assay of Antioxidant Capacity and Phenolic Compounds in some Romanian and Cypriot Wine

Determination of in vitro Antioxidant and Radical Scavenging Activities of Different Extracts of Allium sativum (Garlic)

Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats

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