The effects of pre- and post-natal nicotine exposure and genetic background on the striatum and behavioral phenotypes in the mouse

Balsevich, Georgia; Poon, Anna K.; Goldowitz, Dan; Wilking, Jennifer A.

doi:10.1016/j.bbr.2014.02.038

Cited by 22 publications

(18 citation statements)

References 69 publications

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“…To observe how acute and repeated treatment with THC may differentially affect behavior when administered during adolescence or adulthood we used inbred C57Bl/6J (B6) and DBA/2J (D2) mice from Jackson Laboratories. These strains have been previously demonstrated to exhibit strain- and age-specific differences in NOR, EPM, and open field behaviors at the time of acute adolescent exposure used in the current study (Moore et al, 2011; Balsevich et al, 2014). Identification of strain-specific differences may help to identify genetic markers of THC-related susceptibility.…”

Section: Introductionmentioning

confidence: 84%

“…Thus, it is possible that mice never exposed to shipping stress may display different behavioral responses to THC than that seen in the current study. The use of only male mice in the current study is also a major drawback, as females may show sex-specific differences in these tasks as well as susceptibility to THC treatment in adulthood and across development (Rodriguez de Fonsesca et al, 1993; Podhorna & Brown, 2002; Moore et al, 2007; Llorent-Berzal et al, 2013; Balsevich et al, 2014). Future studies should include female mice and may consider pair housing animals to reduce the harm of long-term isolated housing.…”

Section: Discussionmentioning

confidence: 99%

“…To conserve power, data for B6 and D2 mice were analyzed separately due to differences in baseline behavior seen previously. Independent samples t-tests were also used to determine drug effects in each age group due to previously documented age effects in these tasks (Moore et al, 2010; 2011; Balsevich et al, 2014). Alpha level for t-tests were corrected to .0125.…”

Section: Methodsmentioning

confidence: 99%

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Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Kasten

Zhang

Boehm

2017

Pharmacology Biochemistry and Behavior

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Use of exogenous cannabinoids disrupts the fine-tuned endocannabinoid receptor system, possibly leading to alterations in cognition, memory, and emotional processes that endure long after cannabinoid use has stopped. Long-term adolescent use may uniquely disrupt these behaviors when compared to adult use. The current study explored the acute and long-term behavioral effects of six 10 mg/kg Δ9-tetrahydrocannabinol (THC) injections across the adolescent or early adult period in male inbred C57Bl/6J and DBA/2J mice. The acute and prolonged effects of THC on object memory using the novel object recognition task, unconditioned anxiety in the elevated plus maze and open field, and sedative effects in the open field were examined. Acute THC treatment resulted in anxiogenic activity in both strains, but only caused sedation in B6 mice. Repeated THC treatment resulted in a protracted effect on object recognition, but not unconditioned anxiety, assessed 4 weeks later. In both strains, an adolescent history of THC treatment disrupted later object recognition. Interestingly, in B6 mice an adult history of THC exposure appeared to rescue a deficit in object recognition observed in vehicle-treated adults. Repeated THC administration also produced a protracted effected on CB1R protein expression. Animals treated with THC in adolescence maintained increased levels of CB1R protein expression compared to their adult THC-treated counterparts at five weeks following the last injection. These results indicate that THC use may have long-lasting effects with adolescence being a unique period of susceptibility.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Kasten

Zhang

Boehm

2017

Pharmacology Biochemistry and Behavior

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“…Because of the dynamic nature of developmental processes, the central nervous system is vulnerable to damage by environmental toxins during fetal and early postnatal life [45, 47]. Abnormal behaviors in offspring have been associated with maternal smoking during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Camellia sinensis Prevents Perinatal Nicotine‐Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Ajarem

Al-Basher

Allam

et al. 2017

Oxidative Medicine and Cellular Longevity

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Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible protective effects of green tea (Camellia sinensis) against perinatal nicotine-induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50 mg/kg C. sinensis on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25 mg/kg nicotine from PD12 to D15. Nicotine-exposed newborns showed significant delay in eye opening and hair appearance and declined body weight at birth and at D21. Nicotine induced neuromotor alterations in both male and female newborns evidenced by the suppressed righting, rotating, and cliff avoidance reflexes. Nicotine-exposed newborns exhibited declined memory, learning, and equilibrium capabilities, as well as marked anxiety behavior. C. sinensis significantly improved the physical development, neuromotor maturation, and behavioral performance in nicotine-exposed male and female newborns. In addition, C. sinensis prevented nicotine-induced tissue injury and lipid peroxidation and enhanced antioxidant defenses in the cerebellum and medulla oblongata of male and female newborns. In conclusion, this study shows that C. sinensis confers protective effects against perinatal nicotine-induced neurobehavioral alterations, tissue injury, and oxidative stress in mice newborns.

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“…Prenatal nicotine exposure in CD1 mice led to greater anxiety in the elevated platform and Suok tests but not in the elevated plus maze (Santiago and Huffman 2014). Prenatal and postnatal nicotine exposure to nicotine reduced time spent in open arms in C57BL/6 male mice as adults but increased open-arm time in DBA/2J female adult mice (Balsevich et al 2014). In rats, adolescent nicotine exposure led to decreased exploration in the open field and quicker retreat to the perimeter of the field, suggesting heightened anxiety (Slawecki et al 2003(Slawecki et al , 2004.…”

Section: Nicotine In Development and Anxietymentioning

confidence: 94%

Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?

Foll

Ng²,

Ciano

et al. 2015

The Neuropharmacology of Nicotine Dependence

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Epidemiological studies indicate a high prevalence of tobacco smoking in subjects with psychiatric disorders. Notably, there is a high prevalence of smoking among those with dependence to other substances, schizophrenia, mood, or anxiety disorders. It has been difficult to understand how these phenomena interact with clinical populations as it is unclear what preceded what in most of the studies. These comorbidities may be best understood by using experimental approaches in well-controlled conditions. Notably, animal models represent advantageous approaches as the parameters under study can be controlled perfectly. This review will focus on evidence collected so far exploring how behavioral effects of nicotine are modified in animal models of psychiatric conditions. Notably, we will focus on behavioral responses induced by nicotine that are relevant for its addictive potential. Despite the clinical relevance and frequency of the comorbidity between psychiatric issues and tobacco smoking, very few studies have been done to explore this issue in animals. The available data suggest that the behavioral and reinforcing effects of nicotine are enhanced in animal models of these comorbidities, although much more experimental work would be required to provide certainty in this domain.

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The effects of pre- and post-natal nicotine exposure and genetic background on the striatum and behavioral phenotypes in the mouse

Cited by 22 publications

References 69 publications

Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Camellia sinensis Prevents Perinatal Nicotine‐Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?

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