The effects of pregnancy and parturition on the levels of substance P-like immunoreactivity in different areas of the hypothalamus

Amira, Smain; Morrison, J.F.B.; Rayfield, K. M.

doi:10.1016/0306-3623(94)00241-e

Cited by 1 publication

(1 citation statement)

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“…An increase in SP in the MBH was found in neonatally hyperprolactinemic rats. Similar results were described in puerperal hyperprolactinemia (32). Prolactin also increased in vitro SP release and content in the MBH.…”

Section: Resultssupporting

confidence: 86%

Changes in Substance P Content at the Hypothalamic-Pituitary Axis during the Wallerian Degeneration of Peripheral Sympathetic Neurons after Superior Cervical Ganglionectomy in Male Rats: Effect of Hyperprolactinemia

Duvilanski

Castrillón

Cano

et al. 2001

Exp Biol Med (Maywood)

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The effects of Wallerian degeneration of the peripheral sympathetic neurons projecting to the hypothalamus on the mechanism of interaction between prolactin and substance P (SP) were examined. The effects of superior cervical ganglionectomy (SCGx) on SP content in various hypothalamic regions and in the hypophysis were evaluated in control and hyperprolactinemic rats. Male rats that received pituitary transplants at the age of 5 days and age-matched sham-operated controls were used. Pituitary grafting significantly increased circulating values of prolactin, as did SCGx. In hyperprolactinemic rats, SCGx partially decreased plasma prolactin levels. Neonatal hyperprolactinemia decreased SP content in the anterior (AH) and posterior (PH) hypothalamus and in the median eminence (ME), but increased it in the mediobasal hypothalamus (MBH). Acute SCGx significantly increased SP in the MBH, PH, and ME. SCGx in hyperprolactinemic animals further increased SP content in MBH. In the ME and Ah, SCGx in pituitary grafted rats decreased SP content as compared with the controls. In the pituitary gland (PG), SCGx only decreased SP content in hyperprolactinemic, but not in control rats. An interaction between peripheral noradrenergic neurons and prolactin to regulate SP within the hypothalamus was positive in the MBH, AH, ME, and PG, but not in the PH. These data indicate the existence of interactive mechanisms between prolactin and the peripheral sympathetic neurons to regulate SP content at the hypothalamic-pituitary axis. Interrelationships between prolactin and SP were also observed.

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Section: Resultssupporting

confidence: 86%