The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice

Hahn, Martin E.; Benno, Robert H.; Schanz, Norman; Phadia, Eswar G.

doi:10.1016/s0091-3057(00)00418-4

Cited by 28 publications

(42 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, it can be noted that the virtual absence of gender differences in infant mice calling is in accordance with the vast majority of the literature (Hahn et al 1997, Hahn et al 2000Hahn and Schanz 2002;Roubertoux et al 1996;but see: Hahn et al 1998). …”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 86%

“…The finding that early environmental factors can influence calling behavior is in accordance with studies on the effects of prenatal malnutrition (Tonkiss et al 2003), prenatal stress (Morgan et al 1999;Williams et al 1998), perinatal asphyxia (Calmandrei et al 2004) or pre-and postnatal exposure of various substances, like alcohol (Barron and Gilbertson 2005;Marino et al 2002;Tatolli et al 2001), cocaine (Hahn et al 2000), lead (De Marco et al 2005), aluminum (Alleva et al 1998), or carbon monoxide (Di Giovanni et al 1993) on ultrasonic calling in infant rodents. However, in the natural context, variations in maternal care might be of major importance.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 85%

See 1 more Smart Citation

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

View full text Add to dashboard Cite

Infant rodents emit ultrasonic vocalizations when isolated from dam and littermates. Due to the context of their occurrence and the well described bidirectional modulation by substances known for their capability to influence emotionality, it was postulated that such calls reflect a negative affective state akin anxiety. Comparative studies observed pronounced differences in calling behavior between strains, which were paralleled by differences in maternal care. Therefore, it was recently hypothesized that early environmental factors may have strong impact on call production. Here, the relative contributions of genetic background, gender, and early environmental factors on calling behavior in C57BL/6JOlaHsd and C57BL/6NCrl were studied by using an embryo-transfer procedure. The results show that these sub-strains differ in the amount of calling and specific call features, like call frequency and amplitude. The embryo-transfer procedure indicated that the observed differences in the amount of ultrasonic calling are dependent on the dyadic interaction between mother and pup. Conversely, call features were primarily dependent on the genotype of the pup. Thus, call frequency and frequency modulation were solely dependent on the pup, i.e. its genotype and gender. However, there was one exception, namely call amplitude, which was solely dependent on the genotype of the mother, i.e. on early environmental factors. Furthermore, it was shown that particularly changes in call amplitude might be of high functional relevance, since a sub-strain dependent preference towards pups emitting calls with high amplitudes was observed. In total, it can be concluded that both genomic and nongenomic factors can tune calling behavior in mouse pups.

show abstract

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 86%

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 85%

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Conspecifics appear to interpret and respond to these auditory and olfactory emissions. One well-characterized method for apparent social communicative interactions in rodents is the ultrasonic vocalization that appears to be reflexively emitted by pups when they are out of the nest [Hofer, 1996;Branchi et al, 1998;Brunner et al, 1999;Winslow et al, 2000;Hofer et al, 2001;Hahn and Schanz, 2002]. The parents detect this 50 -80 kHz ultrasonic "distress" call, locate the pup, and retrieve it to the nest.…”

Section: Social Communicationmentioning

confidence: 99%

Designing mouse behavioral tasks relevant to autistic‐like behaviors

Crawley

2004

Ment. Retard. Dev. Disabil. Res. Rev.

451

357

View full text Add to dashboard Cite

The importance of genetic factors in autism has prompted the development of mutant mouse models to advance our understanding of biological mechanisms underlying autistic behaviors. Mouse models of human neuropsychiatric diseases are designed to optimize (1) face validity, i.e., resemblance to the human symptoms; (2) construct validity, i.e., similarity to the underlying causes of the disease; and (3) predictive validity, i.e., expected responses to treatments that are effective in the human disease. There is a growing need for mouse behavioral tasks with all three types of validity for modeling the symptoms of autism. We are in the process of designing a set of tasks with face validity for the defining features of autism: deficits in appropriate reciprocal social interactions, deficits in verbal social communication, and high levels of ritualistic repetitive behaviors. Social approach is tested in an automated three-chambered apparatus that offers the subject a choice between a familiar environment, a novel environment, and a novel environment containing a stranger mouse. Preference for social novelty is tested in the same apparatus, with a choice between the start chamber, the chamber containing a familiar mouse, and the chamber containing a stranger mouse. Social communication is evaluated by measuring the ultrasonic distress vocalizations emitted by infant mouse pups and the parental response of retrieving the pup to the nest. Resistance to change in ritualistic repetitive behaviors is modeled by forcing a change in habit, including reversal of the spatial location of a reinforcer in a T-maze task and in the Morris water maze. Mouse behavioral tasks that may model additional features of autism are discussed, including tasks relevant to anxiety, seizures, sleep disturbances, and sensory hypersensitivity. Applications of these tests include (1) behavioral phenotyping of transgenic and knockout mice with mutations in genes relevant to autism, (2) characterization of mutant mice derived from random chemical mutagenesis, (3) DNA microarray analyses of genes in inbred strains of mice that differ in social interaction, social communication and resistance to change in habit, and (4) evaluation of proposed therapeutics for the treatment of autism.

show abstract

“…In fact, differences in USV rate and acoustic structures have been observed between various strains of mice or rats (Bell et al, 1972;Robinson and D'Udine, 1982;Sales, 1979;Sales and Smith, 1978), and have been shown to be linked to sex (Naito and Tonoue, 1987), single-gene mutations (Bolivar and Brown, 1994;D'Udine et al, 1982), or knockouts (Weller et al, 2001;Winslow et al, 2000). Further, selective breeding for properties of USVs (Brunelli et al, 1997(Brunelli et al, , 2002Brunelli, this issue) and selective crossing of mouse strains to produce genetic variants that were tested for effects on and correlations with USV properties (Hahn et al, 1987(Hahn et al, , 1997(Hahn et al, , 1998Hahn and Schanz, 2002;Hofer et al, 2001;Roubertoux et al, 1996;Thornton et al, this issue) have shown, in summary, that USV rate and probably all acoustic characteristics of USVs have a multiple genetic background. The numerous genetic influences acting on USV properties may add up or subtract in their effects and, depending on the postnatal age, seem to produce a mosaic of changing net-effects with or without becoming statistically significant (see also Brunelli, this issue, for further discussion).…”

Section: Sender Behavior and Signal Propertiesmentioning

confidence: 99%

Infant Rodent Ultrasounds ? A Gate to the Understanding of Sound Communication

2005

View full text Add to dashboard Cite

Components of the communication system between infant and adult rodents based on ultrasonic vocalizations (USVs) of infants are analyzed. USVs are most often emitted from a pup lost outside the nest in response to changes of: (i) body temperature, (ii) contact with adults/littermates, (iii) handling, and (iv) smell. These changes modulate the state of arousal and the emotional/motivational states and, as a result, USVs are produced. Acoustic properties of USVs seem to reflect the degrees of changes in arousal and emotion/motivation. Adult rodents are aroused by perceiving the USVs, locate the sender and show a phonotaxic approach to the sender. Acoustic properties of USVs in the frequency and time domains are described based on which adult rodents discriminate the USVs from other ultrasounds and take the USVs or adequate models of them as preferred goals of their phonotaxic approach. The preferred approach to adequate USVs is modulated by emotions/motivations, the sex of the receiver, hormonal states, experience with pups and neurotransmitter systems of the brain. The phonotaxis can be understood as the appetitive component of a pup-caring instinct. The consummatory act of the instinct is the retrieval of the lost pup. This retrieval is independent of USV presence, but it closes the communication loop activated by the emission of USVs. Communication with USVs can be used as a tool to investigate genetic and brain mechanisms of behavioral control.

show abstract

The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice

Cited by 28 publications

References 23 publications

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Designing mouse behavioral tasks relevant to autistic‐like behaviors

Infant Rodent Ultrasounds ? A Gate to the Understanding of Sound Communication

Contact Info

Product

Resources

About