The Effects of Prenatal Methamphetamine Exposure on Childhood Growth Patterns from Birth to 3 Years of Age

Zabaneh, Rachel N.; Smith, Lynne M.; LaGasse, Linda L.; Derauf, Chris; Newman, Elana; Shah, Rizwan; Arria, Amelia M.; Huestis, Marilyn A.; Haning, William; Strauss, Arthur; Grotta, Sheri Della; Dansereau, Lynne M.; Lin, Hai; Neal, Charles R.; Lester, Barry M.

doi:10.1055/s-0031-1285094

Cited by 31 publications

(28 citation statements)

References 31 publications

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“…Focusing on physical growth patterns, Zabaneh et al (2012) found children exposed prenatally to METH have a modest decrease in height during the first 3 years of life with no observed difference in weight, head circumference, or weight-for-length trajectories. Prenatal METH exposure also is associated with significantly reduced caudate nucleus volume and cortical thickness increases in perisylvian and orbital-frontal cortices Zabaneh et al, 2012). Diffusion tensor imaging (DTI) suggests lower diffusion and higher fractional anisotropy in METHexposed children at 3-4 years of age, indicating that fetal METH may alter white matter tracts .…”

Section: Psychostimulants Methamphetaminementioning

confidence: 96%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

342

241

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Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, often differ from their effects on mature systems. In this review, we describe current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates (among other drugs) produce alterations in neurodevelopmental trajectory. We focus both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies. Early studies of fetal exposures focused on classic teratological methods that are insufficient for revealing more subtle effects that are nevertheless very behaviorally relevant. Modern mechanistic approaches have informed us greatly as to how to potentially ameliorate the induced deficits in brain formation and function, but conclude that better delineation of sensitive periods, dose-response relationships, and long-term longitudinal studies assessing future risk of offspring to exhibit learning disabilities, mental health disorders, and limited neural adaptations are crucial to limit the societal impact of these exposures.

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Section: Psychostimulants Methamphetaminementioning

confidence: 96%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

342

241

View full text Add to dashboard Cite

show abstract

“…Intrauterine exposure causes decreased growth parameters of exposed newborns [8] as well the decreased growth trajectory in the first 3 years of life [10]. Infants that have been exposed to concurrent cigarette smoke as well as methamphetamine in utero are more likely to have intrauterine growth restriction.…”

Section: Methamphetamine In Special Populations: the Pregnant Woman Amentioning

confidence: 99%

“…Infants that have been exposed to concurrent cigarette smoke as well as methamphetamine in utero are more likely to have intrauterine growth restriction. Other long-term consequences are neurobehavioral and include increased aggressive behavior, delayed acquisition of mathematics and language skills, and poorer visual recognition memory [10,11].…”

Section: Methamphetamine In Special Populations: the Pregnant Woman Amentioning

confidence: 99%

Stimulant Methamphetamine and Dextromethorphan Use Among Thai Adolescents: Implications for Health of Women and Children

Chomchai

Manaboriboon

2012

J. Med. Toxicol.

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For over a decade, amphetamine-type stimulants have made their way into the adolescent culture of Thailand. Coupled with the more recent emergence of the legal, overthe-counter cough medicine dextromethorphan (DM), they represent the most commonly abused substances among Thai youths today. Methamphetamine is the second most popular drug of abuse in Thailand, the first being cannabis. It is available in the crystalline version, ICE, and the less pure methamphetamine tablets. The tablets are frequently crushed and smoked. Its use has gained enormous popularity among teenagers and young adults, including women of child-bearing age. As such, it has become the most common drug being detected in the urine of peripartum women, resulting in peripartum and postpartum complications for both mother and child. DM is a newer drug which has gained popularity among middle school and high school students due to its easy availability as a single product over the counter. It is usually taken with soft drinks at parties and gathering. It is metabolized by CYP4502D6 to dextrorphan, the substance responsible for the feeling of euphoria. Consequently, those who are poor metabolizers often experience the "negative" effects associated with the drug. The recreational use of methamphetamine and dextromethorphan in teenagers and young adults in Thailand is a serious problem. Recognizing not only the toxicological but also the emotional and psychosocial impacts of these drugs on Thai youth is an integral part of approaching the problem.

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“…2 Unlike with other drugs of abuse, more women than men are first-time users and comprise one-half of those seeking treatment of MA use, raising concern for the impact of prenatal MA use on children. In 2009, 6.7% of those seeking treatment of MA abuse in the United States were pregnant women. 3 Research on the impact of prenatal MA exposure on child development is emerging from the only large, prospective longitudinal study of prenatal MA use, the Infant Development, Environment, and Lifestyle (IDEAL) study.…”

mentioning

confidence: 99%

“…3 Research on the impact of prenatal MA exposure on child development is emerging from the only large, prospective longitudinal study of prenatal MA use, the Infant Development, Environment, and Lifestyle (IDEAL) study. 4 Previous MA findings from IDEAL include increased small for gestational size at birth 5 and decreased length through 3 years, 6 poor quality of movement, low arousal, and increased stress signs in the newborn period 7 and poor grasping ability at 1 and 3 years of age. 8 The only comparable study conducted in Sweden showed increased drowsiness during the newborn period 9 and increased behavior problems in amphetamineexposed children.…”

mentioning

confidence: 99%

Prenatal Methamphetamine Exposure and Childhood Behavior Problems at 3 and 5 Years of Age

2012

PEDIATRICS

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WHAT'S KNOWN ON THIS SUBJECT: Prenatal methamphetamine exposure has been related to deficits in fetal growth, changes in infant neurobehavior, and fine motor deficits, but little is known about its developmental effects on behavior problems in early childhood. WHAT THIS STUDY ADDS:This is the first prospective study to identify behavior problems associated with prenatal methamphetamine exposure. Mood difficulties and acting-out behavior are increased in exposed children by age 3 years. Early identification and intervention may prevent escalation into delinquency and psychopathology. abstract OBJECTIVE: We evaluated behavior problems in children who were prenatally exposed to methamphetamine (MA) at ages 3 and 5 years. METHODS:The Infant Development, Environment, and Lifestyle study, a prospective, longitudinal study of prenatal MA exposure and child outcome, enrolled subjects postpartum in Los Angeles, California; Honolulu, Hawaii; Des Moines, Iowa; and Tulsa, Oklahoma. Prenatal exposure was determined by maternal self-report and/or meconium results. Exposed and comparison groups were matched on race, birth weight, public health insurance, and education. Mothers in the comparison group denied use and had a negative meconium screen for amphetamines. Prenatal exposures to tobacco, alcohol, or marijuana occurred in both groups. At ages 3 and 5 years, 330 children (166 exposed and 164 comparison) were assessed for behavior problems by using the caregiver report on the Child Behavior Checklist. General linear mixed models were used to determine the effects of prenatal MA exposure, including heavy exposure ($3 days per week), age, and the interaction of exposure and age on behavior problems with adjustment for other drugs of abuse and environmental risk factors. RESULTS:MA exposure was associated with increased emotional reactivity and anxious/depressed problems at both ages and externalizing and attention-deficit/hyperactivity disorder problems by age 5 years. Heavy exposure was related to attention problems and withdrawn behavior at both ages. There were no effects of MA on the internalizing or total behavior problems scales.CONCLUSIONS: This first report of behavior problems in patients as young as 3 years associated with MA exposure identifies an important public health problem. Continued follow-up can inform the development of preventive intervention programs. Pediatrics 2012;129:681-688

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The Effects of Prenatal Methamphetamine Exposure on Childhood Growth Patterns from Birth to 3 Years of Age

Cited by 31 publications

References 31 publications

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Stimulant Methamphetamine and Dextromethorphan Use Among Thai Adolescents: Implications for Health of Women and Children

Prenatal Methamphetamine Exposure and Childhood Behavior Problems at 3 and 5 Years of Age

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