The effects of prolonged fasting on the levels of adiponectin, leptin, apelin, and omentin in pregnant women

Abstract

The aim of the present study was to evaluate serum adiponectin, leptin, apelin and omentin levels to explore metabolic changes occurring during fasting in the month of Ramadan. The study was designed as a prospective study. The patients were divided into two groups, each comprising 20 patients: Group I, fasting pregnant women, and Group II, non-fasting pregnant women. The patients' age, parity, gestational week and body mass index were recorded. Adiponectin and omentin levels were significantly lower in fasting pregnant women (p < 0.001). When the two groups were compared in terms of serum leptin and apelin levels, both were found to be significantly higher in Group I than in Group II. The findings of the present study suggest that pregnant women who are willing to fast during 24-38 weeks' gestation should be informed about insulin resistance.

Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes

“…For women with diabetic pregnancy, the circulating level of adiponectin is low, and this is associated with increased fetal growth [29]. Adiponectin and omentin levels are markedly lower in fasting than non-fasting pregnant women [30]. The decreased serum omentin-1 level may be also related to increased fetal growth.…”

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

“…Of the 494 articles that were retrieved, 20 were included in the meta-analysis; four were apelin studies [4,6,7,11], nine were chemerin studies [5,8,15,16,[23][24][25][26][27], five were omentin studies [28][29][30][31][32], one study involved both apelin and omentin [12], and one study involved both chemerin and omentin [33]. The 20 studies enrolled 2981 participants, of which 1493 were GDM patients and 1488 were healthy pregnant women (controls) [4-8, 11, 12, 15, 16, 23-33] (Fig.…”

“…Elsehmawy et al [10] have described apelin as a novel adipokine that is produced and secreted by mature human adipocytes. Studies of serum or plasma apelin concentration in GDM patients by Baris et al found lower circulating apelin in women with GDM than in controls; however, Emel et al reported an increased apelin concentration in GDM patients [11,12].…”

Peer Review #2 of "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system (v0.3)"

“…Nevertheless, the correlation of APLN levels with GDM has not yet reached an agreement in clinical researches. Three studies reported a decrease of serum APLN level in GDM patients (Aydin, 2010;Boyadzhieva et al, 2013;Akinci et al, 2014) while two other groups revealed an increase (Aslan et al, 2012;Caglayan et al, 2016). In contrast, there were also no significant association reports between normal control and GDM patients (Telejko et al, 2010;Oncul et al, 2013).…”