The effects of prometryne on subchronically treated mice evaluated by SCGE assay

Đikić, Domagoj; Židovec-Lepej, Snježana; Remenar, Anica; Horvat-Knežević, Anica; Benković, Vesna; Lisičić, Duje; Sajli, Lana; Springer, Oskar

doi:10.1556/abiol.60.2009.1.4

Cited by 12 publications

(9 citation statements)

References 18 publications

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“…The only records available in literature refer to the neurotoxic kinetics of atrazine, a pesticide structurally similar to prometryne (23,24,26). Due to similar structure, the two compounds may share some toxicological properties (33,34). Our results confi rm this assumption, as they correspond to the fi ndings of Stoker and Cooper (40), who examined the toxicokinetics of atrazine in rat brain and other organs.…”

Section: Discussionsupporting

confidence: 85%

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Brain Toxicokinetics of Prometryne in Mice

Đikić

Sajli

Benković

et al. 2010

Archives of Industrial Hygiene and Toxicology

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Prometryne is a methylthio-s-triazine herbicide. Signifi cant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg -1 ) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was similar to that reported for the structurally related herbicide atrazine.

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Section: Discussionsupporting

confidence: 85%

“…One of the goals was to compare the allometric differences (30)(31)(32) between rats used in the study of Maynard et al (22) and mice which we regularly used in earlier prometryne toxicity studies (33,34). One of the key documents that directed the experiment was the OECD 407 guideline for 28-day subchronic toxicity studies in rodents (21).…”

Section: Discussionmentioning

confidence: 99%

Brain Toxicokinetics of Prometryne in Mice

Đikić

Sajli

Benković

et al. 2010

Archives of Industrial Hygiene and Toxicology

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“…Since prometryn is widely used across the world as an herbicide to control the growth of annual broadleaf and weeds in many cultivated plants, there are possible cases that humans are at risk of being exposed to prometryn and other commonly used pesticides more than expected. Prometryn is relatively persistent in waters, soil, and even air near application sites [29]. Significant traces of prometryn have been documented to be remnant in plants used for human and domestic animal consumption [30,31] and some medicinal plants that were protected with prometryn [32].…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn

Sule,

Phinney,

Salemi

et al. 2023

IJMS

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Prometryn is a methylthio-s-triazine herbicide used to control the growth of annual broadleaf and grass weeds in many cultivated plants. Significant traces of prometryn are documented in the environment, mainly in waters, soil, and plants used for human and domestic consumption. Previous studies have shown that triazine herbicides have carcinogenic potential in humans. However, there is limited information about the effects of prometryn on the cardiac system in the literature, or the mechanisms and signaling pathways underlying any potential cytotoxic effects are not known. It is important to understand the possible effects of exogenous compounds such as prometryn on the heart. To determine the mechanisms and signaling pathways affected by prometryn (185 mg/kg every 48 h for seven days), we performed proteomic profiling of male mice heart with quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) using ten-plex tandem mass tag (TMT) labeling. The data suggest that several major pathways, including energy metabolism, protein degradation, fatty acid metabolism, calcium signaling, and antioxidant defense system were altered in the hearts of prometryn-treated mice. Proteasome and immunoproteasome activity assays and expression levels showed proteasome dysfunction in the hearts of prometryn-treated mice. The results suggest that prometryn induced changes in mitochondrial function and various signaling pathways within the heart, particularly affecting stress-related responses.

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“…They reported a significant increase in comet TL in atrazine-exposed animals compared to controls, in blood and liver cells. In a study of prometryn on mice exposed to three doses for 28 days, Đikić et al [63] found dose-and exposure-related DNA damage in the leukocytes.…”

Section: Discussionmentioning

confidence: 99%

DNA Damage and Glutathione Peroxidase Activity in Liver and Kidney Cells in Wistar Rats Exposed to Terbuthylazine (TERB) for 28 Consecutive Days

Kašuba¹,

Micek²,

Pizent³

et al. 2021

Rodents

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The potential of low doses of the chloro-triazine herbicide terbuthylazine to induce DNA damage and impair activity of glutathione peroxidase (GPx) was evaluated in kidney and parenchymal and non-parenchymal liver cells of adult male rats. In a 28-day study, terbuthylazine was applied daily by oral gavage at doses: 0.004, 0.4 and 2.29 mg/kg bw/day. Tail Intensity (T Int) and Tail Length (TL) were used as descriptors of DNA damage. In the kidney, Tail Int was significantly different in all treated groups, while TL was different in 0.4 and 2.29 mg/kg bw/day groups, compared to controls. Significant differences in TL were recorded in parenchymal and non-parenchymal liver cells of all treated groups. Tail Int was significantly different from controls in non-parenchymal liver cells at all applied doses and in parenchymal cells at terbuthylazine doses of 0.004 and 2.29 mg/kg bw/day. A significant increase in GPx activity was observed only in the kidney at doses 0.4 and 2.29 mg/kg bw/day compared to the controls indicating its possible role in the protection of kidney from free radicals. It appears that repeated exposure to low doses of terbuthylazine could cause DNA instability in kidney cells and in parenchymal and non-parenchymal liver cells in rats.

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The effects of prometryne on subchronically treated mice evaluated by SCGE assay

Cited by 12 publications

References 18 publications

Brain Toxicokinetics of Prometryne in Mice

Brain Toxicokinetics of Prometryne in Mice

Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn

DNA Damage and Glutathione Peroxidase Activity in Liver and Kidney Cells in Wistar Rats Exposed to Terbuthylazine (TERB) for 28 Consecutive Days

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