The effects of pyospermia and ureaplasma urealyticum culture positivity on semen quality in subfertile men

McGill, John; Baker, Karen; Starks, Christopher; Barazani, Yagil; Sabanegh, Edmund

doi:10.1016/j.fertnstert.2013.07.1302

Cited by 2 publications

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“…This deformity likely develops distortions such as a decrease in the sperm’s overall antioxidant capacity and flaws emerging in DNA repair ( 8 ). Therefore, a positive correlation between U. urealyticum infection and semen parameters suggests that U. urealyticum infection is a possible index of male infertility ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Xianchun

Fang²,

Dai³

et al. 2023

Front. Endocrinol.

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IntroductionUreaplasma urealyticum (U. urealyticum) infection is primarily associated with damage to male fertility through its effects on male sperm parameters. However, its effects on sperm semiological variables remain unclear. Therefore, this study aimed to investigate whether U. urealyticum infection was associated with semen quality and sperm morphology.MethodsFrom 2019 to 2021, this cross-sectional study analyzed infective pathogens and semen variables in 1064 males (22–30 years old) recruited from our reproductive center and the general public. Routine semen parameters and normal sperm morphology rate were analyzed using methods outlined by the World Health Organization. The associations between semen quality, sperm morphology, and U. urealyticum infection were studied using general linear models.ResultsThe participants were categorized into three groups: (i) U. urealyticum infection (n=328), (ii) non-U. urealyticum infection (including males with urogenital tract infection symptoms but no U. urealyticum detected in their semen samples, n=377), and (iii) normal volunteers (males without symptoms of urogenital tract infection and no pathogens detected in semen samples, n=359). U. urealyticum in semen samples was observed to be associated with lower sperm concentrations (p<0.001) and a lower ratio of anterograde motile spermatozoa (p<0.001). Semen cultures positive for U. urealyticum were associated with lower normal sperm morphology (p<0.001) compared to semen cultures negative for U. urealyticum.ConclusionThis study shows the importance of proper investigations for U. urealyticum during routine clinical examinations and diagnoses of males with infertility.

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Section: Introductionmentioning

confidence: 99%

Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Xianchun

Fang²,

Dai³

et al. 2023

Front. Endocrinol.

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Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males

Yang

Zou

Zhou

et al. 2018

Eur J Clin Microbiol Infect Dis

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Whether Ureaplasma spp. are a causative agent of male infertility remains controversial. Previous studies concerning Ureaplasma spp. and male infertility have been confined to the species level of Ureaplasma. Currently, an expanded multilocus sequence typing (eMLST) scheme has been established with high discriminatory power. The aim of this study was to use eMLST to explore the distribution of Ureaplasma spp. and to analyze its role in oligozoospermia and semen quality. A total of 480 semen samples were obtained from Chinese infertile males. The associations between Ureaplasma spp. with oligozoospermia and semen characteristics were further evaluated. Phylogenetic analysis revealed that 102 Ureaplasma spp. could be separated into two clusters and seven sub-groups. Within cluster I (U. parvum), eST16 and eST41 were the most frequent clones. For cluster II (U. urealyticum), eST82 and eST147 were the most prevalent clones. Sub-groups A and C belonging to cluster I and sub-group 1 belonging to cluster II showed an association with oligozoospermia, in contrast with the Ureaplasma spp. negative group (P < 0.05). Compared with the negative group, semen motility decreased in sub-group 2, especially for non-progressive motility (P < 0.05). These results indicated that sub-groups A and C belonging to cluster I (U. parvum) and sub-group 1 belonging to cluster II (U. urealyticum) were shown to be associated with oligozoospermia. Sub-group 2 belonging to cluster II may have the ability to impair semen motility, especially for non-progressive motility.

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The effects of pyospermia and ureaplasma urealyticum culture positivity on semen quality in subfertile men

Cited by 2 publications

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Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males

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