2019
DOI: 10.1016/j.bbamem.2019.04.009
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The effects of radioprotectant and potential antioxidant agent amifostine on the structure and dynamics of DPPC and DPPG liposomes

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Cited by 15 publications
(2 citation statements)
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“…[ 20 ] For example, amifostine, the first FDA‐approved intravenous radioprotector in the clinic, achieved the radioprotection by eradicating the toxic free radicals induced by irradiation. [ 21 ] Therefore, the potential of CNSI as a radioprotector was preliminarily evaluated by comparing its radical scavenging ability with amifostine in vitro. First, two classical model radicals, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical and 2,2′‐azinobis (3‐ethylbenzthiazoline‐6‐sulfonate) (ABTS), were applied for comparison.…”
Section: Resultsmentioning
confidence: 99%
“…[ 20 ] For example, amifostine, the first FDA‐approved intravenous radioprotector in the clinic, achieved the radioprotection by eradicating the toxic free radicals induced by irradiation. [ 21 ] Therefore, the potential of CNSI as a radioprotector was preliminarily evaluated by comparing its radical scavenging ability with amifostine in vitro. First, two classical model radicals, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical and 2,2′‐azinobis (3‐ethylbenzthiazoline‐6‐sulfonate) (ABTS), were applied for comparison.…”
Section: Resultsmentioning
confidence: 99%
“…Thirdly, its administration was associated with DNA condensation reducing damage efficiency ( 386 ). Fourthly, amifostine may alter lipid membrane dynamics affecting membrane proteins and therefore it can influence downstream signaling pathways of transmembrane receptors ( 387 ).…”
Section: Protecting Normal Tissue During Radiotherapymentioning
confidence: 99%