The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts

Akgun-Unal, Nilufer; Özyıldırım, Serhan; Ünal, Ömer; Gulbahce-Mutlu, Elif; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım

doi:10.1016/j.exger.2022.112043

Cited by 6 publications

(6 citation statements)

References 69 publications

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“…It is noteworthy that the dietary supplementation with resveratrol over RCL and HFHLD significantly elevated the serum melatonin level compared with the findings of group 2. Earlier studies on the diabetic-aged rat model demonstrated that the effect of resveratrol and melatonin administered separately and their combination could increase SIRT1 gene expression in heart tissue [ 18 ] that can lead to the reduction of the activity of several pro-inflammatory and pro-oxidant transcription factors, such as NF-κB, STAT3, FOXO, and p53 [ 26 ]. The NF-κB suppression restricts the transcription of the crucial enzyme in pineal melatonin synthesis—arylalkylamine N-acetyltransferase [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a natural phytoalexin, is also able to concurrently suppress NF-κB and activate Nrf2–antioxidant response element (ARE) signalling pathway [ 15 , 16 ], alleviate NF-κB-dependent pro-inflammatory hypercytokinaemia and endothelium dysfunction (in higher degree compared to quercetin) [ 17 ], and, in combination with melatonin, enhances antioxidant activity and decreases gene expression of the insulin-regulated glucose transporter GLUT4, sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in heart tissue in a diabetic aged rat model [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Frenkel

Черно

Kostenko³

et al. 2023

Pathophysiology

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This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were randomly divided into 3 groups: control (group 1, n = 7); HFHLD for 8 weeks + round-the-clock lighting (RCL) (group 2, n = 7); HFHLD + RCL + Resveratrol (in a daily dose of 5 mg/kg intragastrically (group 3, n = 7). Results show that the combined effect of HFHLD and RCL reduces the serum melatonin (p < 0.001) and accelerates pro-inflammatory activities, oxidative stress, and metabolic disorder. There is a significant increase in the serum tumour necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) (both p < 0.001), blood malondialdehyde—thiobarbituric acid adducts (MDA-TBA2) (p < 0.001), serum glucose (p < 0.01), insulin concentration, and the homeostatic model assessment insulin resistance (HOMA-IR) index (both p < 0.001), serum with very low-density lipoprotein (VLDL), and triacylglycerol (TAG) (both p < 0.001). At the same time, the decrease in the serum high-density lipoprotein (HDL) level (p < 0.001) is observed in the HFHLD + RCL group compared to the control. In the HFHLD + RCL + Resveratrol group, hypomelatonaemia (p < 0.001), pro-inflammatory actions, oxidative stress, and metabolic disorder were mitigated. Resveratrol can cause a significant rise in the serum melatonin and reduce serum TNF-α and CRP levels (both p < 0.001), blood MDA-TBA2 (p < 0.001), serum glucose (both p < 0.01), insulin concentration, and HOMA-IR (both p < 0.001), serum VLDL and TAG (both p < 0.001) compared to the group 2, while serum HDL level increases (p < 0.01). Resveratrol attenuates pro-inflammatory responses and prevents considerable metabolic disorder in rats fed HFHLD under RCL.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Frenkel

Черно

Kostenko³

et al. 2023

Pathophysiology

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“…SIRTs represent a family of enzymes, primarily functioning as NAD + -dependent deacetylases, consisting of seven members in humans and other mammals [30,31]. Bene cial effects of RSV have been recently documented in a diabetic elderly female rat model, in which RSV-treatment resulted in cardioprotective activity [32,33].…”

Section: Anti-in Ammatory Action Of Rsvmentioning

confidence: 99%

Anti-inflammatory action of resveratrol in the central nervous system in relation to glucose concentration - an in vitro study on a blood-brain barrier model

Komorowska,

Watroba,

Bednarzak

et al. 2024

Preprint

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Objective and Design: This study aimed to investigate the anti-inflammatory properties of resveratrol (RSV) on astrocyte cytokine profiles within the in vitro model of blood-brain barrier (BBB) under varying glucose concentrations (2.2, 5.0, and 25.0 mmol/L). Material:The subjects comprised the in vitro co-cultures of endothelial cells and astrocytes within the BBB model with 0.4-µm-wide pores between them. Treatment:RSV was administered at a dosage of 50 μM to the microvascular compartment (MC), and the duration of the intervention was 24 hours. Methods: Cytokine levels (IL-1 α, IL-1 β, IL-2, IL-4, IL-6, IL-8) in the brain compartment (BC) were assessed using a Multi-Analyte ELISArray Kit before and after the addition of LPS and RSV. Statistical analysis was conducted to determine significance levels. Results: RSV significantly reduced the concentration of all studied cytokines in the BC, regardless of glucose levels. The most substantial decrease occurred under normoglycemic conditions. The concentration of RSV in the BC was highest in normoglycemic conditions compared to hypo- and hyperglycemia. Conclusions:Administration of RSV in the MC demonstrated anti-inflammatory effects within BC, particularly in normoglycemia-simulating conditions. Future in vivostudies, including animal and human research, are needed to explore the bioavailability of RSV within the CNS.

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“…Epigallocatechin gallate (EGCG), a natural antioxidant, reduced high glucoseinduced oxidative stress and inhibited cardiac interstitial fibrosis in a diabetic rat model [38]; Curcumin, a natural polyphenol, reduced oxidative stress and inhibited Akt/GSK-3βinduced fibrosis in a diabetic rat model [39]; and N-acetylcysteine (NAC), a glutathione precursor, reduced high glucose-induced oxidative stress and inhibited interstitial fibrosis in a diabetic mice model [40]. Melatonin, a natural antioxidant, and Resveratrol, a natural polyphenol, also reduced oxidative stress and inhibited myocardial interstitial fibrosis in a diabetic rat model [41]. These are just a few examples of the many studies investigating pharmacological inhibitors targeting oxidative stress and myocardial interstitial fibrosis in diabetic cardiomyopathy.…”

Section: Ros-dependent Microvascular Inflammationmentioning

confidence: 99%

The Role of Cardiac Fibrosis in Diabetic Cardiomyopathy: From Pathophysiology to Clinical Diagnostic Tools

Pan

Hsu

Chang

et al. 2023

IJMS

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Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to inadequate insulin secretion, resistance, or both. The cardiovascular complications of DM are the leading cause of morbidity and mortality in diabetic patients. There are three major types of pathophysiologic cardiac remodeling including coronary artery atherosclerosis, cardiac autonomic neuropathy, and DM cardiomyopathy in patients with DM. DM cardiomyopathy is a distinct cardiomyopathy characterized by myocardial dysfunction in the absence of coronary artery disease, hypertension, and valvular heart disease. Cardiac fibrosis, defined as the excessive deposition of extracellular matrix (ECM) proteins, is a hallmark of DM cardiomyopathy. The pathophysiology of cardiac fibrosis in DM cardiomyopathy is complex and involves multiple cellular and molecular mechanisms. Cardiac fibrosis contributes to the development of heart failure with preserved ejection fraction (HFpEF), which increases mortality and the incidence of hospitalizations. As medical technology advances, the severity of cardiac fibrosis in DM cardiomyopathy can be evaluated by non-invasive imaging modalities such as echocardiography, heart computed tomography (CT), cardiac magnetic resonance imaging (MRI), and nuclear imaging. In this review article, we will discuss the pathophysiology of cardiac fibrosis in DM cardiomyopathy, non-invasive imaging modalities to evaluate the severity of cardiac fibrosis, and therapeutic strategies for DM cardiomyopathy.

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The effects of resveratrol and melatonin on biochemical and molecular parameters in diabetic old female rat hearts

Cited by 6 publications

References 69 publications

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Anti-inflammatory action of resveratrol in the central nervous system in relation to glucose concentration - an in vitro study on a blood-brain barrier model

The Role of Cardiac Fibrosis in Diabetic Cardiomyopathy: From Pathophysiology to Clinical Diagnostic Tools

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