The effects of rifampicin on wound healing

Karapolat, Banu; Karapolat, Sami; Buran, Alaaddin; Okatan, Burcu Kemal

doi:10.5455/annalsmedres.2019.10.662

Cited by 2 publications

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“…[ 33 ] In another study on skin defect healing in rats, it was reported that the recovery rates did not differ at the end of the study (10 days), but RF had positive effects on collagen accumulation and shrinkage of the skin defect in the initial stage (third and seventh days). [ 34 ] A review of the literature indicates that various proinflammatory agents, such as interleukin-1 beta and tumor necrosis factor-alpha (TNF-α), have been shown to impede the formation of type 1 collagen, leading fibroblasts to increase the synthesis of catabolic and inflammatory enzymes. [ 12 , 35 ] Notably, a study suggests that inhibiting TNF-α contributes to enhanced tendon strength following repair.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats

Mahsut Dincel,

Can,

Karabag

2023

Jt Dis Relat Surg

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Objectives This study aimed to examine the effect of irrigation fluids containing povidone-iodine (PVP-I), rifampicin (RF), and chlorhexidine gluconate (CHG) used during surgery on healing on a rat Achilles tendon model. Materials and methods Twenty-eight male Sprague-Dawley rats (range, 300 to 400 g) were used in the experiment carried out between November 2022 and December 2022. The rats were divided into PVP-I, RF, CHG, and control groups, with seven rats in each group. Following the tenotomy and repair of the right Achilles tendon, the surgical site was irrigated using PVP-I, RF, CHG, or normal saline (the control group) for 2 min. All rats were sacrificed on the 21 st postoperative day. The samples were evaluated histomorphometrically using the scoring system modified by Svensson, Soslowsky, and Cook and histopathologically using the Bonar and Movin classifications. Results The RF group gave better results in all three scoring systems compared to the control, PVP-I, and CHG groups (p=0.008, p=0.002, and p=0.006, respectively). Cellularity, rounding, and tenocyte morphology showed a significant difference in favor of the RF group (p=0.004). While the distribution of ground substance glycosaminoglycans showed a significant difference in favor of the RF group, there was no significant difference among the other groups (p=0.22). Conclusion Irrigation solutions containing PVP-I, RF, or CHG show no negative effect on Achilles tendon healing. Moreover, the findings suggest that RF irrigation can accelerate the healing process.

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Section: Discussionmentioning

confidence: 99%

Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats

Mahsut Dincel,

Can,

Karabag

2023

Jt Dis Relat Surg

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“…5-Nitrofurazone (chemical name, 2-[(5-Nitro-2-furanyl)methylene]-hydrazinecarboxamide; CAS No, 59-87-0; molecular formula, C 6 H 6 N 4 O 4 ; Figure 1) generally exists as a lemon yellow fine crystalline powder, which starts to melt and decompose when heated to about 511.15 K. 5-Nitrofurazone has wide antibacterial spectrum, with antibacterial activity against gram-positive negative bacteria, and also has a certain effect on anaerobic bacteria. 1 Due to its multiactivity nature, 5nitrofurazone was found to have potential for reuse and development. 2 El-Wakil et al 3 reported the repurposing of the antimicrobial drug 5-nitrofurazone as a potential anticancer agent against CaCo-2 and HepG-2 cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Thermodynamic Modeling of 5-Nitrofurazone in Pure Solvents and Binary Solvent Mixtures

Yan

et al. 2023

J. Chem. Eng. Data

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In this work, the solubility of 5-nitrofurazone (Form α) in 10 pure solvents (water, methanol, ethanol, acetonitrile, ethyl acetate, n-propanol, isopropanol, acetone, formamide, N,N-dimethylformamide) and two binary mixed solvents (N,N-dimethylformamide + water, N,N-dimethylformamide + acetonitrile) were measured by ultraviolet–visible spectrophotometry from 278.15 to 313.15 K. The experimental results showed that the solubility of 5-nitrofurazone (Form α) in all pure solvents and binary mixed solvents was positively correlated with temperature. Additionally, the modified Apelblat equation, the λh equation, and the nonrandom two-liquid (NRTL) model were used to correlate the experimental solubility results. The results showed that all of these models could correlate the experimental data well, and the modified Apelblat equation provided the best fitting results. Finally, the mixing and dissolution thermodynamic properties of 5-nitrofurazone (Form α) in 10 pure solvents and two binary solvents, including enthalpy, entropy, and Gibbs energy, were calculated by experimental results and the NRTL model.

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The effects of rifampicin on wound healing

Cited by 2 publications

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Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats

Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats

Solubility and Thermodynamic Modeling of 5-Nitrofurazone in Pure Solvents and Binary Solvent Mixtures

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