The effects of RNA interference mediated VEGF gene silencing on biological behavior of renal cell carcinoma and transplanted renal tumor in nude mice

Abstract

The VEGF gene silencing could inhibit the cell proliferation, migration and invasion of RCC 786-O cells; inhibition of VEGF protein expression could prevent transplanted RCC growth and tumor angiogenesis.

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

“…These data suggested that CD73 promoted cervical cancer cells proliferation and migration, which was dependent of its non-enzyme activity. EGFR and VEGF have been believed to promote cancer growth and metastasis [ 20 – 23 ]. Co-expression of CD73 and EGFR or VEGF has been found in other type of cancers [ 24 – 26 ].…”

Decreased expression of BRAF-activated long non-coding RNA is associated with the proliferation of clear cell renal cell carcinoma

“…For localized RCC, it has been estimated that more than 25% patients encounter metastases at first visit, while another 25% experience local advancement [ 4 ]. Moreover, RCC has shown strong resistance to radiotherapy and chemotherapy [ 5 , 6 ]. Over the last decade, great progress has been made in genetic and epigenetic variations concerning RCC; Yet, the precise mechanism of RCC pathogenesis still remains unclear.…”

Effects of RNA interference-mediated gene silencing of VEGF on the ultrafiltration failure in a rat model of peritoneal dialysis

“…Vascular endothelial growth factor (VEGF) has a great impact on assorted cells, such as neurones, skeletal muscle, and cardiac cells [ 10 ]. VEGF often functions with gene silencing, which could ultimately act to inhibit cell proliferation, migration, and invasion in relation to the treatment of various diseases [ 11 ]. Moreover, VEGF plays a significant role in wound healing, growth of certain solid tumors, and ascites formation [ 12 ].…”