The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats

Abstract

We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were randomly divided into an untreated control group (C), a C + RSG group which was treated with RSG (4 mg kg(-1)) two times a day by gavage, a diabetic group (D) that was treated with a single intraperitoneal injection of STZ (45 mgkg(-1)), D + RSG group which were treated with RSG two times a day by gavage, respectively. Lipid profiles, HbA(1c) and blood glucose levels in the circulation and malondialdehyde (MDA) and 3-nitrotyrosine (3-NT) levels in left ventricular muscle were measured. Treatment of D rats with RSG resulted in a time-dependent decrease in blood glucose. We found that the lipid profile and HbA(1c) levels in D + RSG group reached the C rat values at the end of the treatment period. There was a statistically significant difference between the C + RSG and C groups in 3-NT levels. In group D, 3-NT and MDA levels were found to be increased when compared with C, C + RSG and D + RSG groups. In the D + RSG group, MDA levels were found to be decreased when compared with C and C + RSG. Our study suggests that the treatment of D rats with RSG for 8 weeks may decrease the oxidative/nitrosative stress in left ventricular tissue of rats. Thus in diabetes-related vascular diseases, RSG treatment may be cardioprotective.

Neuroprotective effect of resveratrol in diabetic cerebral ischemic-reperfused rats through regulation of inflammatory and apoptotic events

“…One week later, blood samples were collected and processed for blood glucose determination. Rats which achieved fasting serum glucose level ≥200 mg/dl were considered diabetic and selected for this study [17] . …”

Deterioration of Bone Quality by Streptozotocin (STZ)-Induced Type 2 Diabetes Mellitus in Rats

“…At the end of the acclimation period, the rats were divided randomly into two groups: nondiabetic (n=8; intact group) and diabetic rats (n= 8; STZ-induced). Diabetes was induced by single intravenous injection of STZ (45 mg/kg [30,31]) dissolved in 0.01 M sodium citrate (pH adjusted to 4.5) under ether anesthesia. After 3 days following STZ administration, blood was collected from tail vein, and samples were analyzed for blood glucose by using a glucometer (Aquo-Check, Roche).…”

Antinociceptive and antiallodynic effects ofMomordica charantiaL. in tibial and sural nerve transection-induced neuropathic pain in rats

“…Earlier, PPAR-gamma agonists have also been reported to decrease oxidative stress. 50 Hence, the results of this study give the impression that TST-induced nociceptive alterations may be due to the dysregulation of PPAR-gamma receptor activity along with increase in inflammation and oxidative stress. Therefore, it may be proposed that MCmediated PPAR-gamma agonistic activity, antiinflammatory activity, and decrease in the oxidative stress are responsible for its ameliorative role in TSTinduced neuropathic pain.…”