The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress

Tang, Jing; Liang, Xin; Zhang, Yang; Chen, Linmu; Wang, Feifei; Tan, Chuanxue; Luo, Yang; Xiao, Qian; Chao, Feng‐lei; Zhang, Lei; Gao, Yuan; Huang, Chunxia; Qi, Yingqiang; Tang, Yong

doi:10.1016/j.brainresbull.2019.04.001

Cited by 38 publications

(31 citation statements)

References 60 publications

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“…In addition, animal studies have indicated that physical exercise could increase the oligodendrocyte proliferation in the PFC of animal models 32 , while other studies have demonstrated that physical exercise showed the opposite effect on oligodendrocyte proliferation but enhanced oligodendrocyte differentiation 33 . Treadmill running has been reported to alleviate the depressive-like behavior in several animal models useful for the study of depression 27,34–37 . Our previous studies found that running exercise had positive effects on the myelinated fibers of white matter and the oligodendrocytes of the hippocampus in rats exposed to CUS 36,37 .…”

Section: Introductionmentioning

confidence: 99%

“…Treadmill running has been reported to alleviate the depressive-like behavior in several animal models useful for the study of depression 27,34–37 . Our previous studies found that running exercise had positive effects on the myelinated fibers of white matter and the oligodendrocytes of the hippocampus in rats exposed to CUS 36,37 . However, the effects of running exercise on the mPFC volume and the oligodendrocytes in the mPFC in the context of MDD are unclear.…”

Section: Introductionmentioning

confidence: 99%

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Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

et al. 2019

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Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase+ oligodendrocytes and Olig2+ oligodendrocytes, reduced the ratio between Olig2+/NG2+ oligodendrocytes and Olig2+ oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2+ oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

et al. 2019

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“…In adult male Sprague‐Dawley rats, 4 weeks of chronic unpredictable stress increased depressive‐like behaviors, as evidenced by a decrease of sucrose consumption. This behavioral change was accompanied by a decrease in the oligodendrocyte markers MBP and oligodendrocyte transcription factor 2 (Olig2) . In attempts to reverse this, 4 weeks of running exercise was introduced to these animals.…”

Section: Myelin Maturationmentioning

confidence: 99%

“…This behavioral change was accompanied by a decrease in the oligodendrocyte markers MBP and oligodendrocyte transcription factor 2 (Olig2). 108 In attempts to reverse this, 4 weeks of running exercise was introduced to these animals. Data collected show that exercise restored MBP and Olig2 levels to those seen in nonstressed controls, as well as reversed anhedonia in stress-exercised rats.…”

Section: Synaptic Maturationmentioning

confidence: 99%

Adolescent maturation of the prefrontal cortex: Role of stress and sex in shaping adult risk for compromise

Shaw

Dupree

Neigh

2019

Genes Brain and Behavior

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Adolescence is a highly dynamic period of development, which includes the final organizational phases of neural maturation within the prefrontal cortex (PFC). The organizational events of neural pruning and myelination occur in a sex‐specific manner, potentially giving rise to the disparities in mood disorders in adulthood. Because of the extended developmental time period of the PFC, environmental insults, including psychosocial stressors, may play a major role in steering the maturation of this region. In this review, the literature surrounding the sex specific alterations that occur in the PFC in rodent models following adolescent stress will be discussed. This will be complimented by a brief review on the state of human research in PFC sex differences in the development of white matter and cytoarchitecture across the lifespan. Taken together, the impact of developmental psychosocial stress on the circuitry of the PFC and resulting adult phenotypes will be summarized with a focus on the importance of considering sex differences in order to build a better understanding of developmental influences on adult disorders.

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“…Bu çalışmanın amacı serebral hipoperfüzyon koşullarında EE'nin etkisinin depresyon benzeri davranış, BDNF, IL-1β ve kaspaz-1 düzeylerinin belirlenmesiyle değerlendirmektir. (35). Depresyonda IL-1β gibi proinflamatuar sitokinlerin artışının yanı sıra BDNF düzeylerinde azalmanın olduğu da bildirilmiştir (36).…”

Section: Glialunclassified

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

Çengil¹,

Özaçmak²,

TURAN³

et al. 2019

MJWBS

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Bu çalışma çevresel zenginleştirmenin (EE) kronik serebral hipoperfüzyonla (KSH) oluşturulan vasküler demans modelinde depresyon benzeri davranış, serebral korteks ve hipokampüsde beyin kaynaklı nörotrofik faktör (BDNF), kaspaz-1 ve IL-1β seviyeleri üzerine etkisini incelemek için tasarlanmıştır. Daha önceki çalışmalar EE'nin KSH modelinde oksidatif stres inhibisyonu ve endojen nörokoruyucu faktörlerin artırılmasını içeren yararlı etkilere sahip olduğunu göstermişlerdir. Gereç ve Yöntemler: KSH sıçanlarda bilateral ortak karotid arterlerin oklüzyonu ile oluşturulmuştur. Hayvanlar 3 gruba ayrılmıştır: Sham, standart kafes koşulları ve 4 hafta boyunca zenginleştirilmiş koşullara maruz bırakılan grup. Sükroz tercih testi ve zorlu yüzme testi (FST) KSH sonrası depresif davranışı değerlendirmek için kullanılmıştır. BDNF, IL-1β ve kaspaz-1 düzeylerindeki değişim incelenmiştir. Bulgular: KSH, hipokampüsde BDNF seviyesinde azalmaya, IL-1β ve kaspaz-1 düzeylerinde artış ile birlikte depresyon benzeri davranışa neden olmuştur.. Sonuç: EE serebral hipoperfüzyon durumunda inflamatuar yanıtı azaltarak ve BDNF seviyelerini koruyarak depresif davranışı iyileştirmede farmakolojik olmayan yeni bir strateji olabilir.

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The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress

Cited by 38 publications

References 60 publications

Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

Adolescent maturation of the prefrontal cortex: Role of stress and sex in shaping adult risk for compromise

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

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