The Effects of Salvianolate Combined With Western Medicine on Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Shen, Yuehong; Wang, Shulin; Liu, Yuanyuan; Ge, Lan; Xia, Lili; Zhang, Xiaoxiao; Miao, Yuying; Shen, Jianping; Zhou, Qian

doi:10.3389/fphar.2020.00851

“…As mentioned above, for patients with peripheral neuropathy caused by glucose metabolism disorder, the treatment method of integrated traditional Chinese and western medicine is very helpful for the rapid recovery of the patient's health [10] . From the results, it also has a significant improvement compared with the original physical condition.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Peng

¹

,

Duan

²

2021

JCNR

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Objective: Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine, and the final results were observed. Methods: 70 patients with such symptoms were randomly divided into two groups. The number of people is the same, and the treatment methods are different. The control group uses western medicine, while the observation group uses traditional Chinese medicine to evaluate the treatment effect. Results: After treatment, the effective rate of the observation group was (P < 0.05), indicating that the treatment effect was significantly better. Conclusion: Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair, and with Chinese medicine, the effect is more satisfactory, and the effect is positive, so as to promote the optimization of their health.

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“…Studies stating that participants had renal damage, but without baseline GFR, Ccr, or SCr; participants with diabetic nephropathy. These issues had been investigated in a previous study [ 13 ]; studies involving Salvia miltiorrhiza as one of several active components in a compound recipe were not included.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of Salvia miltiorrhiza for Treating Chronic Kidney Diseases: A Systematic Review and Meta-Analysis

Zhang

¹

,

Li²,

Yang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This meta-analysis evaluated the effects and potential harms of Salvia miltiorrhiza or its extracts Salvianolate and Tanshinone for the treatment of population with a chronic kidney disease (CKD). Methods. We searched for the randomized clinical trials (RCTs) through databases including the Cochrane Library, PubMed, Embase, Web of Science, Current Controlled Trials, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Biology Medicine Disc (SinoMed), and Chinese Clinical Trial Registry (ChiCTR). Meta-analysis was performed with STATA 16 software after data extraction. The risk of bias was assessed with the Cochrane risk-of-bias tool (RoB 2.0), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework was employed to evaluate the quality of evidence. Result. A total of 32 studies were included involving 2264 participants. Compared to the control group, the treatment group significantly decreased serum creatinine (SCr) (SMD −0.60, 95% CI −0.79 to −0.41, P < 0.0001 ), blood urea nitrogen (BUN) (SMD −0.66, 95% CI −0.81 to −0.50, P < 0.0001 ), Cystatin C (CysC) (SMD −5.16, 95% CI −14.84 to 4.53, P = 0.297 ), 24 hour urine protein (24 h UPE) (SMD −0.70, 95% CI −1.21 to −0.19, P = 0.008 ), time to initiation of dialysis (Log RR 0.43, 95% CI 0.23 to 0.81, P = 0.0089 ), serum total cholesterol (TC) (SMD −0.53, 95% CI −0.88 to −0.17, P = 0.0042 , P = 0.0035 ), plasma fibrinogen (FIB) (SMD −0.79, 95% CI −1.12 to −0.46, P < 0.0001 ), C-reactive protein (CRP) (SMD −0.56, 95% CI −0.93 to −0.19, P = 0.0029 ); increased creatinine clearance (Ccr) (SMD 0.92, 95% CI 0.43 to 1.41, P = 0.0002 ), glomerular filtration rate (GFR) (SMD 0.56, 95% CI 0.30 to 0.83, P < 0.001 ), effective rate (Log RR 0.30, 95% CI 0.23 to 0.37, P < 0.0001 ), and hemoglobin (Hb) (SMD 0.42, 95% CI 0.13 to 0.71, P = 0.0042 ). Moreover, the incidences of adverse effects were similar between the two groups. Conclusions. Salvia miltiorrhiza or its extracts Salvianolate and Tanshinone, as a complementary therapy to conventional medicine, presents potential impacts to improve kidney functions and delay the progression of CKD without obvious adverse effects. However, the certainty of the evidence and the risk of bias are suboptimal and further clinical studies are still required to determine the underlying effects.

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“…Therefore, the dysbiosis of gut microbiota has a critical effect on DKD. Increased evidence has demonstrated that a number of natural products could improve the dysbiosis of gut microbiota in DKD [68][69][70][71][72].…”

Section: Iga Nephropathymentioning

confidence: 99%

Recent advances of gut microbiota in chronic kidney disease patients

Zhao

¹

2022

Exploration of Medicine

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Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of these pathological development and progression remains to be fully understood. The human gut microbiota is made up of approximately 100 trillion microbial cells including anaerobic and aerobic species. In recent years, more and more evidence has indicated a clear association between dysbiosis of gut microbiota and CKD including immunoglobulin A (IgA) nephropathy, diabetic kidney disease, membranous nephropathy, chronic renal failure and end-stage renal disease. The current review describes gut microbial dysbiosis and metabolites in patients with CKD thus helping to understand human disease. Treatment with prebiotics, probiotics and natural products can attenuate CKD through improving dysbiosis of gut microbiota, indicating a novel intervention strategy in patients with CKD. This review also discusses therapeutic options, such as prebiotics, probiotics and natural products, for targeting dysbiosis of gut microbiota in patients to provide more specific concept-driven therapy strategy for CKD treatment.

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The Effects of Salvianolate Combined With Western Medicine on Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Cited by 14 publications

References 49 publications

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Efficacy and Safety of Salvia miltiorrhiza for Treating Chronic Kidney Diseases: A Systematic Review and Meta-Analysis

Recent advances of gut microbiota in chronic kidney disease patients

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