The Effects of Satureja hortensis L. Dried Leaves on Serum Sugar, Lipid Profiles, hs-CRP, and Blood Pressure in Metabolic Syndrome Patients: A Double-Blind Randomized Clinical Trial

Nikaein, Farzad; Babajafari, Siavash; Mazloomi, Seyed Mohammad; Zibaeenezhad, Mohammad Javad; Zargaran, Arman

doi:10.5812/ircmj.34931

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Another study compared the cardiovascular-protective effect of cardamom, cinnamon, saffron, and ginger, demonstrating that all of them showed potent abilities in controlling blood pressure and improving endothelial function [ 33 ]. Besides, daily ingestion of Satureja hortensis L. effectively improved the lipid profile in patients with metabolic syndrome by lowering TC, TG, and LDL-C and increasing HDL-C [ 109 ]. Moreover, garlic and cumin showed a strong hypotensive effect on patients with type 2 diabetes [ 110 ].…”

Section: Clinical Trialsmentioning

confidence: 99%

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Zhou

Luo

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.

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Section: Clinical Trialsmentioning

confidence: 99%

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Zhou

Luo

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…This plant is resistant to various weather conditions and has many medicinal properties, such as antioxidant, antifungal, antibacterial, and antiseptic properties. Moreover, it is an LDL cholesterol-lowering agent rich in oily and protein substances [16][17][18][19]. Interestingly, from the 305 articles searched in the Scopus database between the years 1989 to 2018, 209 papers had focused on the summer savory effects [19].…”

Section: Introductionmentioning

confidence: 99%

Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract

Ahmadi

Fazilati

Mousavi

et al. 2020

Journal of Experimental Nanoscience

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Nowadays, the expansion of nanoparticles as antimicrobial and anticancer agents is one of the most exciting methods for cancer therapy and microbial diseases that can vanquish the problems of drug resistance. In this research, the biosynthesis of silver nanoparticles (AgNPs) was stated using Summer Savory extract. Moreover, these AgNPs by UV-Vis spectroscopy, FTIR, XRD, FESEM, EDX, PSA, and zeta potential analysis were characterized, and by antimicrobial and anti-cancerous performance was evaluated. The maximum absorption peak at 472 nm by UV-Visible spectra confirmed the formation of Ag nanoparticles. The results obtained by FT-IR determined the presence of organic compounds such as amines, alkenes, alcohols, phenols, which performed significant roles in the fixating of these nanoparticles. The results obtained from FESEM, EDX, PSA, and Zeta Potential Analysis revealed that synthesized AgNPs had a hexagonal structure with a size ranging from 10 to 100 nm. The antimicrobial properties of the synthesized AgNPs were examined by Minimum Inhibitory Concentration, Minimum Bactericidal Concentration, and Minimum Fungal Concentration against five microbial strains included Klebsiella pneumonia, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Saccharomyces cerevisiae. The results demonstrated that biosynthesized AgNPs had the most antimicrobial activity, especially against E. Coli. The anti-cancerous results of these nanoparticles through MTT assay demonstrated exceptional anticancer effects against K-562 and MCF-7 human cancer cell lines with IC50 values 50 and 200 mg/ml, respectively.

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“…Upon evaluating the results of the studies, it becomes evident that herbs play a significant role in addressing various aspects of metabolic syndrome. A wide array of herbs have demonstrated the capacity to directly influence key metabolic parameters such as blood pressure, blood glucose levels, lipid profiles, obesity, and cholesterol and triglyceride levels ( Nikaein et al, 2016 ; Seong et al, 2021 ; Amin et al, 2015 ; Belcaro et al, 2013 ; Devaraj et al, 2013 ; Najmi et al, 2013 ; Mansouri et al, 2012 ; Shah et al, 2012 ; Basu et al, 2010 ; Gupta Jain et al, 2017 ; Mopuri et al, 2018 ; Cicolari et al, 2020 ; Chae et al, 2022 ; Dobhal et al, 2022 ; Jakovljevic et al, 2018 ; Reshidan et al, 2019 ; Verhoeven et al, 2015 ; Gurrola-Dlaz et al, 2010 ; Benkhaled et al, 2022 ; Li et al, 2020 ; Hermans et al, 2020 ; De Martin et al, 2018 ; Mayer et al, 2022 ; Kasabri et al, 2014 ; Tan et al, 2011 ; Kuate et al, 2015 ; Kho et al, 2016 ). However, while the breadth of herbs studied is extensive, evaluations reveal variations in their efficacy and mechanisms of action.…”

Section: Resultsmentioning

confidence: 99%

Natural products for managing metabolic syndrome: a scoping review

Abdulghani,

Al-Fayyadh

2024

Front. Pharmacol.

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IntroductionMetabolic syndrome comprises a collection of metabolic disorders stemming from factors like genetic predisposition, inadequate nutrition, stress, decreased physical activity, aging, and ethnicity. Although traditional pharmaceutical treatments exist for metabolic syndrome, their limited popularity is attributed to high costs and adverse effects. Consequently, natural products with fewer side effects have been explored for managing this condition. This literature review aims to explore the role of natural products including herbs, botanicals, vitamins, minerals, probiotics, and dietary supplements in managing metabolic syndrome.MethodsThis scoping review was conducted in five steps, involving the formulation of a research question, the retrieval and extraction of relevant studies, the selection of pertinent studies, the organization of information into tables, and the reporting of results. Data was collected from various databases including Embase, Science Direct, PubMed, Google Scholar, Scopus, and Web of Science, with a focus on studies published from 2010 to the present, available in English and with full-text accessibility.ResultsWe identified 1,259 articles, screened their titles, abstracts, and full texts, ultimately incorporating 169 pertinent articles into this review (comprising 90 review articles, 32 trial articles, 6 in vitro articles, 38 in vivo articles, 1 experimental article and 2 observational articles). The study’s outcomes revealed that natural products, encompassing plants and their derivatives, vitamins and supplements, as well as probiotics, can exert a beneficial influence on metabolic syndrome by regulating blood sugar, blood pressure, lipid profiles, obesity, and abnormal cholesterol and triglyceride levels.ConclusionThe current study underscores the significance of natural products in addressing metabolic syndrome. Consequently, it is advisable to conduct further extensive research to assess the efficacy of these products, potentially integrating them into treatment regimens for individuals with metabolic syndrome.

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The Effects of Satureja hortensis L. Dried Leaves on Serum Sugar, Lipid Profiles, hs-CRP, and Blood Pressure in Metabolic Syndrome Patients: A Double-Blind Randomized Clinical Trial

Cited by 8 publications

References 31 publications

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract

Natural products for managing metabolic syndrome: a scoping review

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