1998
DOI: 10.1007/s002130050546
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The effects of selected antidepressant drugs on timing behaviour in rats

Abstract: It has been suggested that the increased reinforcement rate on a differential-reinforcement-of-low-rate of responding (DRL) schedule observed following acute antidepressant administration in the rat is due to an improvement in timing accuracy. The aim of the present work was to evaluate the effects of antidepressants in another schedule that requires accurate estimation of time intervals, the peak procedure. Three antidepressant drugs were tested, the tricyclic antidepressant imipramine (1.0-10.0 mg/kg, i.p.) … Show more

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Cited by 40 publications
(29 citation statements)
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“…To our knowledge, the effect of d-amphetamine on performance on the free-operant psychophysical procedure has not been examined previously. However, the effects seen here closely resemble previously reported effects of d-amphetamine and related drugs in another free-operant timing schedule, the fixed-interval peak procedure (Meck 1986(Meck , 1996Frederick and Allan 1996;Kraemer et al 1997; but see also Bayley et al 1998). In terms of pacemaker/accumulator models of timing, the effects are consistent with a combination of two separate effects, reduction of the period of the pacemaker (reduced T 50 ) and an impairment of the precision of timing (increased Weber fraction) (Gibbon et al 1997).…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…To our knowledge, the effect of d-amphetamine on performance on the free-operant psychophysical procedure has not been examined previously. However, the effects seen here closely resemble previously reported effects of d-amphetamine and related drugs in another free-operant timing schedule, the fixed-interval peak procedure (Meck 1986(Meck , 1996Frederick and Allan 1996;Kraemer et al 1997; but see also Bayley et al 1998). In terms of pacemaker/accumulator models of timing, the effects are consistent with a combination of two separate effects, reduction of the period of the pacemaker (reduced T 50 ) and an impairment of the precision of timing (increased Weber fraction) (Gibbon et al 1997).…”
Section: Discussionsupporting
confidence: 82%
“…However, some studies have yielded results that do not support this hypothesis. For example, Bayley et al (1998) found no effect of d-amphetamine on peak time in the fixed-interval peak procedure, and there have been several reports of d-amphetamine and the D 2 receptor agonist quinpirole having inconsistent effects on temporal discrimination in conditional discrimination tasks or, in some cases, inducing a bias towards the operandum associated with the shorter duration, consistent with an increase, rather than a decrease, of the bisection point (Stubbs and Thomas 1974;Rapp and Robbins 1976;Lejeune et al 1995;Santi et al 1995;Stanford and Santi 1998).…”
Section: Introductionmentioning
confidence: 98%
“…Psychostimulant drugs, which promote dopamine release or block dopamine uptake, for example methamphetamine, d-amphetamine and cocaine, have generally been found to reduce peak time (i.e. to displace the function to the left) in this schedule (Maricq et al 1981;Eckerman et al 1987;Meck 1996;Kraemer et al 1997;Buhusi and Meck 2002;Matell et al 2004, Saulsgiver et al 2006; however, see Bayley et al 1998, for an exception). The effect of psychostimulants on peak time is believed to be mediated mainly by D 2 -like dopamine receptors because the effect can be mimicked by the D 2 -like dopamine receptor agonist quinpirole (Frederick and Allen 1996) and an effect opposite to that of the psychostimulants (i.e.…”
Section: Introductionmentioning
confidence: 93%
“…Unfortunately, the effects of DA agents on intervaltiming tasks have occasionally been inconsistent with some authors reporting results that support a clockspeed interpretation (e.g., Abner et al 2001;Buhusi and Meck 2002;Cevik 2003;Drew et al 2003;Eckerman et al 1987;Frederick and Allen 1996;Liao and Cheng 2005;Maricq and Church 1983;Maricq et al 1981;Meck 1983Meck , 1986Meck , 1996, while others finding general disruptions to temporally controlled behavior, as evidenced by a flattening of the timing function (e.g., Bayley et al 1998;Frederick and Allen 1996;McClure et al 2005;Odum et al 2002;Odum and Ward 2004;Santi et al 1995). In light of these inconsistencies, recent reports have begun calling into question the mechanism by which dopaminergic drugs impact timing and time perception.…”
Section: Introductionmentioning
confidence: 94%