The Effects of Sildenafil Citrate on Choroidal Thickness as Determined by Enhanced Depth Imaging Optical Coherence Tomography

Vance, Sushma K; Imamura, Yutaka; Freund, K. Bailey

doi:10.1097/iae.0b013e3181eef0ae

Cited by 158 publications

(95 citation statements)

References 23 publications

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“…16 In previous studies, sildenafil citrate has been reported to increase choroidal thickness due to a vasodilatory effect of sildenafil citrate on the choroidal circulation. 17 This correlation was further investigated by Kim et al 18 using swept-scan high-frequency digital ultrasound to measure the ocular blood flow. In addition, in a latter study by Ulas¸et al, 19 significant choroidal thinning was noted in chronic renal failure patients after hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

Karalezlı

Şimşek

Çelik

et al. 2014

Eye

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Purpose The purpose of this study was to assess choroidal thickness in migraine patients during acute migraine attacks and compare them with healthy controls, using spectral domain optical coherence tomography (OCT). Patients and methods In this prospective case-control study, choroidal thicknesses of 46 migraine patients during acute migraine attacks and 46 age-and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain-OCT device. All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (0900 hours), in order to minimize the effects of diurnal variation. Results There was a statistically significant difference in mean choroidal thickness between the migraine patients during acute migraine attacks (356.3 ± 21.46 mm) and the controls (302.3 ± 18.34 mm; P ¼ 0.000). There were significant differences at all measurement points (Po0.001 for all). Conclusion The increased choroidal thickness of the migraine patients during acute migraine attacks might be related to the vascular pathology of the disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and acute migraine attack.

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Section: Discussionmentioning

confidence: 99%

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

Karalezlı

Şimşek

Çelik

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

“…However, in two different studies, the authors reported that sildenafil citrate increases choroidal thickness because of the vasodilatory effect of sildenafil citrate on the choroidal circulation. 25,26 Histopathological studies showed that PEX accumulations in the ocular and peribulbar tissues have been detected not only in affected eyes, but also clinically unaffected eyes and therefore it was stated that the socalled unilateral PEX syndrome is clinically asymmetric rather than truly unilateral. 27 Our study showed that the eyes of patients in the bilateral PEX group (group 3) and the affected eyes of the patients in the unilateral PEX group displayed choroidal thicknesses that were thinner than those of the eyes of normal subjects (group 4) and the unaffected eyes of the patients in the unilateral PEX group (group 2).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome

Eroglu

Asena

Şimşek

et al. 2015

Eye

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“…We also excluded patients taking medication implicated in altering the choroidal vasculature, including corticosteroid and sildenafil. 20,21 For the estimation of SFCT, after complete resolution of SRF in CSC, SFCT of 32 normal volunteers were also evaluated.…”

Section: Methodsmentioning

confidence: 99%

Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy

Kang

2013

Eye

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Purpose To assess the change in subfoveal choroidal thickness (SFCT) in central serous chorioretinopathy (CSC) following spontaneous resolution and low-fluence photodynamic therapy (PDT) using the enhanced depth imaging optical coherence tomography (EDI-OCT). Methods A total of 36 consecutive eyes of 36 patients were included in this retrospective study: 16 eyes with spontaneously resolved CSC and 20 eyes with PDT-treated CSC. Best-corrected visual acuity and SFCT were evaluated at each visit until complete absorption of the subretinal fluid. SFCT of 32 normal subjects were also measured, as the control group. Wilcoxon's singed-rank test was used to evaluate the effects of spontaneous resolution and PDT. To compare the SFCT of the eyes with resolved CSC with that of the normal eyes, Mann-Whitney U-test with Bonferroni correction was also employed. Results SFCT of patients was 459.16 ± 77.50 lm at the baseline, and decreased to 419.31±54.49lm after a spontaneous resolution (P ¼ 0.015). However, SFCT was not normalized in comparison with that of the normal subjects (Po0.001). SFCT in PDT group was also reduced from 416.43 ± 74.01 to 349.50 ± 88.99 lm (Po0.001), with no significant difference with the normal value (P ¼ 0.087).Conclusions SFCT in patients with CSC decreased both after spontaneous resolution and low-fluence PDT. However, only in the PDT group, after disappearance of subretinal fluid, did it decrease to that of normal subjects.

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The Effects of Sildenafil Citrate on Choroidal Thickness as Determined by Enhanced Depth Imaging Optical Coherence Tomography

Cited by 158 publications

References 23 publications

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study

Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome

Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy

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