The effects of silver dressings on chronic and burns wound healing

Elliott, Chris

doi:10.12968/bjon.2010.19.sup5.77707

Cited by 67 publications

(27 citation statements)

References 20 publications

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“…The extensive knowledge of respondents is also demonstrated in their awareness of early signs and symptoms of the disease, which was reported as either a painless itch or boils or rashes. These are consistent with biomedical knowledge Elliott, 2010;Nienhuis et al, 2010). These findings could serve as entry points for educational messages targeting early reporting to the health facility for diagnosis and treatment.…”

Section: Discussionsupporting

confidence: 79%

Community Knowledge and Perceptions about Buruli Ulcers in Obom Sub-District of the Ga South Municipality in the Greater Accra Region of Ghana

Koka¹

2018

AASoci

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Community knowledge and perceptions of the cause and consequently the appropriate measure to remedy an ailment determine whom people turn to for advice, help, information and treatment when bogged down with a disease. The role that community plays in the etiology, explanation, prognosis and treatment seeking behaviour cannot be underscored, because it provides in-depth information on the burden of the disease, the local understanding of the causes of the disease and therefore its management. The purpose of the study was to describe community knowledge and perceptions about Buruli ulcer (BU) and how to prevent Buruli ulcer in the Obom sub-district of Ghana. Survey questionnaire was used as an instrument for data collection to solicit information on community knowledge and perceptions of Buruli ulcer in the communities. In selecting respondents for the community survey, systematic sampling was used to select 300 respondents for the study. The study revealed a high level of knowledge about Buruli ulcer in the selected endemic communities. However, Buruli ulcer patients were perceived as people who have been bewitched (36.7%). Others (21%) blamed them as people who did not take good care of themselves while another 11.1% saw Buruli ulcer infected people as having normal wounds. Findings therefore show that although there was a high knowledge of signs and symptoms of Buruli ulcer among community members in the Obom sub-district, their understandings and interpretations of its causative factors varied from those of the biomedical understandings. Based on the results of the study, it is recommended that community outreach and education on the treatment and management of Buruli ulcer should be continued on a sustainable basis in the endemic communities.

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Section: Discussionsupporting

confidence: 79%

Community Knowledge and Perceptions about Buruli Ulcers in Obom Sub-District of the Ga South Municipality in the Greater Accra Region of Ghana

Koka¹

2018

AASoci

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“…For example, AgNPs could be used as substrates for Surface Enhanced Raman Scattering (SERS) to probe single molecules [6], and also useful catalysts for the oxidation of methanol to formaldehyde [7]. AgNPs has been known as excellent antimicrobial and anti-inflammatory agents, and thus were used to improve wound healing [8]. To date, a number of physical and chemical strategies were employed for the synthesis of AgNPs [9,10].…”

Section: Introductionmentioning

confidence: 99%

Fungus-Mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus

Qian

et al. 2011

IJMS

426

165

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The biosynthesis of nanoparticles has received increasing attention due to the growing need to develop safe, cost-effective and environmentally friendly technologies for nano-materials synthesis. In this report, silver nanoparticles (AgNPs) were synthesized using a reduction of aqueous Ag+ ion with the culture supernatants of Aspergillus terreus. The reaction occurred at ambient temperature and in a few hours. The bioreduction of AgNPs was monitored by ultraviolet-visible spectroscopy, and the AgNPs obtained were characterized by transmission electron microscopy and X-ray diffraction. The synthesized AgNPs were polydispersed spherical particles ranging in size from 1 to 20 nm and stabilized in the solution. Reduced nicotinamide adenine dinucleotide (NADH) was found to be an important reducing agent for the biosynthesis, and the formation of AgNPs might be an enzyme-mediated extracellular reaction process. Furthermore, the antimicrobial potential of AgNPs was systematically evaluated. The synthesized AgNPs could efficiently inhibit various pathogenic organisms, including bacteria and fungi. The current research opens a new avenue for the green synthesis of nano-materials.

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“…Due to their antibacterial activity, silver-nanoparticles (NPs) are used commonly in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. In medical applications, silver-NPs have been used for silver-based dressings [1,2], silver-coated catheters [3,4], silver-based hydrogel [5-7]. Silver-NP-hydrogel composites are composed of silver-NP and hydrogel which are used as carrier for silver particles.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

Takemura

et al. 2012

J Nanobiotechnol

124

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BackgroundSince silver-nanoparticles (NPs) possess an antibacterial activity, they were commonly used in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. Various silver-NP based medical devices are available for clinical uses, such as silver-NP based dressing and silver-NP based hydrogel (silver-NP-hydrogel) for medical applications. Although the previous data have suggested silver-NPs induced toxicity in vivo and in vitro, there is lack information about the mechanisms of biological response and potential toxicity of silver-NP-hydrogel.MethodsIn this study, the genotoxicity of silver-NP-hydrogel was assayed using cytokinesis-block micronucleus (CBMN). The molecular response was studied using DNA microarray and GO pathway analysis.Results and discussionThe results of global gene expression analysis in HeLa cells showed that thousands of genes were up- or down-regulated at 48 h of silver-NP-hydrogel exposure. Further GO pathway analysis suggested that fourteen theoretical activating signaling pathways were attributed to up-regulated genes; and three signal pathways were attributed to down-regulated genes. It was discussed that the cells protect themselves against silver NP-mediated toxicity through up-regulating metallothionein genes and anti-oxidative stress genes. The changes in DNA damage, apoptosis and mitosis pathway were closely related to silver-NP-induced cytotoxicity and chromosome damage. The down-regulation of CDC14A via mitosis pathway might play a role in potential genotoxicity induced by silver-NPs.ConclusionsThe silver-NP-hydrogel induced micronuclei formation in cellular level and broad spectrum molecular responses in gene expression level. The results of signal pathway analysis suggested that the balances between anti-ROS response and DNA damage, chromosome instability, mitosis inhibition might play important roles in silver-NP induced toxicity. The inflammatory factors were likely involved in silver-NP-hydrogel complex-induced toxic effects via JAK-STAT signal transduction pathway and immune response pathway. These biological responses eventually decide the future of the cells, survival or apoptosis.

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The effects of silver dressings on chronic and burns wound healing

Cited by 67 publications

References 20 publications

Community Knowledge and Perceptions about Buruli Ulcers in Obom Sub-District of the Ga South Municipality in the Greater Accra Region of Ghana

Community Knowledge and Perceptions about Buruli Ulcers in Obom Sub-District of the Ga South Municipality in the Greater Accra Region of Ghana

Fungus-Mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus

Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

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