The effects of smoking and indomethacin on small intestinal permeability

Suenaert, Peter; Bulteel, Veerle; Hond, Elly Den; Hiele, Martin; Peeters, Maria C. W.; Monsuur, Fred; Ghoos, Yvo; Rutgeerts, Paul

doi:10.1046/j.1365-2036.2000.00754.x

Cited by 47 publications

(34 citation statements)

References 18 publications

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“…kg -1 ), since the aim of these studies was to induce macroscopic lesions in the GIT mucosa, such as ulceration. In contrast, in study of Suenaert et al (2000) on human volunteers the drug at a dose of 125 was administered only in order to increase IP. Thus, the doses of IM as well as the route of drug administration in our experiment were based on the design of these human studies, taking into account the weight difference between calves and adult humans.…”

Section: Discussionmentioning

confidence: 99%

“…IP may also be enhanced with some chemical or physical stimuli, long-time fasting, exercise (Pals et al, 1997), following the administration of non-steroid antiinflammatory drugs (Suenaert et al, 2000;Gotteland et al, 2001) or alcohol (Napolitano et al, 1995). IP is also enhanced by the exposure to γ-radiation, mainly during abdominal or pelvic rtg-examination (Pia de la Maza et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Fasting and experimentally induced abdominal burn injury was used in rats (Pernet et al, 1998). In human volunteers, IP was experimentally enhanced, e.g., with endotoxin (O'Dwyer et al, 1988) or by nonsteroidal antiinflammatory drugs such as Indomethacin (Suenaert et al, 2000;Gotteland et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of intestinal permeability in preruminant calves by lactulose/mannitol test

Klein¹,

Moravcová²,

Kleinová³

et al. 2007

J. Anim. Feed Sci.

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The aim of this study was to utilize the lactulose/mannitol test for assessment of intestinal permeability (IP) in preruminant calves. IP was increased experimentally by administration of Indomethacin. Both sugar markers were determined simultaneously as silyl-derivates in 5 h urinary production using the gas liquid chromatography technique. The index of IP was determined as the ratio between urinary recovery (%) of 10 g lactulose to 5 g D-mannitol. The IP index in control calves was 0.242±0.048. Doses of 20 and 60 mg Indomethacin did not significantly affect IP, but the IP index was significantly enhanced in calves receiving 120 mg of drug (0.541±0.091; P<0.01). Results of this study show that ratio of lactulose to D-mannitol in urine reflected the treatment by the highest dose of Indomethacin and that the test may be used for determination of IP in preruminant calves.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of intestinal permeability in preruminant calves by lactulose/mannitol test

Klein¹,

Moravcová²,

Kleinová³

et al. 2007

J. Anim. Feed Sci.

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“…71 Indomethacin, a nonsteroidal inflammatory drug, increases intestinal permeability, but this effect is abrogated in smokers. 72 Another study on UC subjects, however, did not show significant improvement in intestinal permeability in smokers. 73 Nicotine may influence inflammation in IBD through direct ligand-receptor binding of the nicotinic acetylcholine receptors (nAChR) of the small bowel.…”

Section: 21mentioning

confidence: 99%

Review article: ulcerative colitis, smoking and nicotine therapy

Lunney

Leong

2012

Aliment Pharmacol Ther

121

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SummaryBackgroundSmoking is the best‐characterised environmental association of ulcerative colitis (UC). Smoking has been observed to exert protective effects on both the development and progression of UC.AimsTo examine the association between UC and smoking, possible pathogenic mechanisms and the potential of nicotine as a therapeutic agent in the treatment of UC.MethodsA literature search was conducted through MEDLINE, using the MeSH search terms ‘ulcerative colitis’ and ‘smoking’ or ‘nicotine’. Relevant articles were identified through manual review. The reference lists of these articles were reviewed to include further appropriate articles.ResultsUlcerative colitis is less prevalent in smokers. Current smokers with a prior diagnosis of UC are more likely to exhibit milder disease than ex‐smokers and nonsmokers. There is conflicting evidence for smokers having reduced rates of hospitalisation, colectomy and need for oral corticosteroids and immunosuppressants to manage their disease. Multiple potential active mediators in smoke may be responsible for these clinical effects, including nicotine and carbon monoxide, but the precise mechanism remains unknown. Nicotine has demonstrated variable efficacy in the induction of remission in UC when compared to placebo and conventional medicines. Despite this, the high frequency of adverse events limits its clinical significance.ConclusionsNicotine's application as a therapeutic treatment in ulcerative colitis is limited. Presently, it may be an option considered only in selected cases of acute ulcerative colitis refractory to conventional treatment options. This review also questions whether nicotine is the active component of smoking that modifies risk and inflammation in ulcerative colitis.

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“…Finally, chronic exposure of rats to nicotine inhibits the antibody-forming cell response, impairs the antigenmediated signaling in T-cells and induces T-cell anergy [62] . Other effects of nicotine or smoking on the intestine include the alteration of gut motility, the reduction of smooth muscle tone and contractility (modulated by nitric oxide) [63] , decreased permeability [64] , and alterations in the microcirculation [65] , Furthermore, smoking also increases lipid peroxidation.…”

Section: Mechanisms Behind the Effect Of Smoking On Ibdmentioning

confidence: 99%

Smoking in inflammatory bowel diseases: Good, bad or ugly?

Lakatos¹

2007

WJG

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Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn's disease (CD). A recent meta-analysis partially confirmed previous findings that smoking was found to be p r o t e c t i v e a g a i n s t u l c e r a t i v e c o l i t i s a n d , a f t e r onset of the disease, might improve its course, d e c r e a s i n g t h e n e e d f o r c o l e c t o m y . H o w e v e r , smoking increases the risk of developing Crohn's disease and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Smoking cessation aggravates ulcerative colitis and improves Crohn's disease. Data are however, largely conflictive as well as the potential mechanisms involved in this dual relationship are still unknown. In this review article, the authors review the role of smoking in inflammatory bowel diseases.

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The effects of smoking and indomethacin on small intestinal permeability

Cited by 47 publications

References 18 publications

Assessment of intestinal permeability in preruminant calves by lactulose/mannitol test

Assessment of intestinal permeability in preruminant calves by lactulose/mannitol test

Review article: ulcerative colitis, smoking and nicotine therapy

Smoking in inflammatory bowel diseases: Good, bad or ugly?

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