The effects of starvation, high fat diets, and ketone infusions on uric acid balance

Lecocq, Frank R.; McPhaul, John J.

doi:10.1016/s0026-0495(65)80039-7

Cited by 60 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rare instances, hyperketonemia, by reducing renal uric acid clearance, can raise plasma uric acid to levels sufficient to precipitate a flare in gout-susceptible individuals [22]. Drugs that inhibit uric acid synthesis can prevent this complication.…”

Section: Clinical Response Of a Patient With Ad Dementia To Kme Trmentioning

confidence: 99%

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

Newport¹,

VanItallie²,

Kashiwaya³

et al. 2014

Alzheimer's & Dementia

174

157

View full text Add to dashboard Cite

BackgroundProviding ketone bodies to the brain can bypass metabolic blocks to glucose utilization and improve function in energy‐starved neurons. For this, plasma ketones must be elevated well above the ≤0.2 mM default concentrations normally prevalent. Limitations of dietary methods currently used to produce therapeutic hyperketonemia have stimulated the search for better approaches.MethodDescribed herein is a new way to produce therapeutic hyperketonemia, entailing prolonged oral administration of a potent ketogenic agent—ketone monoester (KME)—to a patient with Alzheimer's disease dementia and a pretreatment Mini‐Mental State Examination score of 12.ResultsThe patient improved markedly in mood, affect, self‐care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20‐month treatment period. Cognitive performance tracked plasma β‐hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.ConclusionKME‐induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet.

show abstract

Section: Clinical Response Of a Patient With Ad Dementia To Kme Trmentioning

confidence: 99%

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

Newport¹,

VanItallie²,

Kashiwaya³

et al. 2014

Alzheimer's & Dementia

174

157

View full text Add to dashboard Cite

show abstract

“…4 The exeessive aeeumulation of urate has been shown to result from aeeelerated nucleoprotein breakdown during the initial period of fasting 12 and from impairment of renal urate clearanee. 2,4,5,7,11,14 In order to prevent or minimize hyperurieemia during fasting, drugs ean be used to reduee urate synthesis or to inerease renal clear-anee of urie acid. Experienee has shown that urieosurie drugs are not entirely satisfactory for this purpose.…”

mentioning

confidence: 99%

The effect of allopurinol on the hyperuricemia of fasting

Drenick

Fisler

Dennin

1971

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

F asting obese subjects were treated with allopurinol or probenecid in order to prevent systemic and renal complications of hyperuricemia. Allopurinol in a dose of 600 mg. per day curbed excessive urate synthesis during early fasting. Renal urate excretion in the allopurinol-treated subjects was the same as that of untreated patients. Urinary oxypurine excretion increased 400 per cent during administration of allopurinol. When 600 mg. of allopurinol per day was given during the first month of fasting and 300 mg. per day during the second month, a uricosuric agent was not needed. Stable and neal' normal serum urate levels during the second month of fasting could be maintained in some subjects with the aid of uricosuric probenecid, permitting a gross estimate of a daily urate turnover rate of 480 to 500 mg. This suggests that during prolonged fasting, the initially accelerated catabolism of nucleoprotein decreases, although to a lesser degree than that of body protein in general.

show abstract

“…In each instance this complication of established cardiovascular ~Began probenecid 500 mg. t.i.d. 14 None of these subjects had a history of gout for many years. When permitted a daily "leave" from the hospital to visit his office, which was nearby, he took a circuitous route and walked rwo miles each way.…”

Section: Prtwentable Hasardamentioning

confidence: 99%