The Effects Of Stem Cells On Epilepsy

Abstract

Epilepsy is a neurological disorder that yields recurring and uncontrollable seizures, as a result of the hypersynchronous discharge of neurons that impacts individuals of all ages. Cases of epilepsy are classified by seizure type and etiology. Antiepileptic drugs (AEDs) are the standard treatment for the disorder, but surgical and neurostimulation options are also available; however, none of the mentioned treatments are 100% effective in eliminating seizures in epileptic patients. One-fifth of those diagnosed with epilepsy are AED resistant, also known as refractory epilepsy. Stem cell transplantation is a regenerative therapy capable of replacing non-functional cells in the brains of those with epilepsy. Embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs) are capable of differentiating into specialized cell types. Stem cell therapy as an alternative treatment of epilepsy has exhibited success by way of preclinical animal research and clinical trials.

Anti-Oxidative Property of Pennisetum Glaucum (Poaceae) Supplement Contributes To Its Anti- Convulsant Activity In Pentylenetetrazole- Kindled Wistar Rats

“…NEpilepsy remains a common cause of morbidity and mortality in spite of the advances in management regimens [1]. People with epilepsy are at higher risk of death than those without epilepsy with an adjusted life years (a measure of the years lost living in those with the disease) of more than 13 million globally [2]. In addition, epilepsy burden caused 14.8 million disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost due to premature mortality and years lived with disability) [3].…”