The Effects of Stilbestrol on the Retention of Nitrogen, Calcium, Phosphorus, and Potassium in Aged Males with and without Osteoporosis

Bogdonoff, Morton D.; Shock, N. W.; Parsons, Janis

doi:10.1093/geronj/9.3.262

Cited by 24 publications

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“…Bogdanoff, Shock and Parsons (4) showed in their all‐male study that administration of 6 mg. of stilbestrol daily produced a downward trend in the amount of retained nitrogen, and that there was no evidence that stilbestrol had any additional influence on nitrogen retention in subjects who received an adequate amount of protein in their diet. In our earlier studies, moderate amounts of estrogen (Progynon B) given to elderly subjects showing positive nitrogen balance produced no marked changes in nitrogen retention (3).…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

“…Our earlier studies as well as those of other investigators demonstrated that androgens, especially testosterone, play a significant role in the retention of nitrogen in older people (1) and that under certain circumstances other hormone substances (2), including estrogens, assist in this retention. It has also been shown that estrogens when administered alone generally have relatively little influence on the ability of elderly persons to retain additional nitrogen (1,3,4).Since there are different forms of chemical compounds which have estrogenlike activity (5), it was thought desirable to study further the influence of the various compounds which act similarly, in order to ascertain whether there is a difference in the effect of these important substances on nitrogen retention in elderly people. It has been established that estradiol, when it is needed, tends to increase nitrogen retention in elderly subjects.…”

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The Action of Chlorotrianisene (Tace) With Androgen on Nitrogen Retention in Elderly People

Kountz¹,

Kheim²,

Toro³

et al. 1959

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The Action of Chlorotrianisene (Tace) With Androgen on Nitrogen Retention in Elderly People

Kountz¹,

Kheim²,

Toro³

et al. 1959

J American Geriatrics Society

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“…The basis for my discussion stems from studies carried out in our laboratories, in collaboration with Dr. Morton Bogdonoff and Dr. Donald Watkin, utilizing the metabolic balance technic (8, 9).…”

Section: Schematic Presentation Of Factors Influencing Spontaneous Anmentioning

confidence: 99%

Panel Discussion on Osteoporosis†

Shorr¹,

László²,

Shock³

et al. 1957

J American Geriatrics Society

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Senile Osteoporosis

Moldawer¹

1955

AMA Arch Intern Med

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OSTEOPOROSIS is as universal an alteration of aging bone as is osteoarthritis of aging joints. Together these comprise the main symptom-producing manifestations of skeletal senility. Although osteoporosis appears to be physiological in aging bone, its degree is very variable from person to person. PATHOLOGICAL PHYSIOLOGYPathologically, osteoporotic bone is characterized by fewer and less thick trabeculae. Functionally such bone is more susceptible to compression and fracture, but until fracture occurs there is preservation of bone contour. So far as is now known, there is no biochemical difference between the thin trabeculae and those of normal presenile bone ; the protein matrix is the same, as is the bone salt, which is deposited in the matrix in an apatite crystal lattice. The ratio of minerals to matrix is probably the same in osteoporotic as in normal bone.The skeleton is normally in a state of dynamic equilibrium, with bone resorption and bone production occurring constantly at dif¬ ferent trabecular surfaces (Fig., left). Re¬ sorption of bone salt is a passive process, which occurs because the body fluids are undersaturated with respect to calcium and phosphorus, the main components of the bone salt. Concomitant with résorption of the bone salt the matrix in which it had been deposited disappears. Osteoclasts are an index of this process and are engaged in the removal of the matrix. Bone production is an active process : Osteoblasts manufacture ma¬ trix and the enzyme alkaline phosphatase, which increases the local concentration of phosphorus by its action on organic phos¬ phates. The increased phosphorus concen¬ tration permits immediate precipitation of bone salt into the newly formed bone matrix.The number of osteoblasts is an index of the activity of bone production. The level of the serum alkaline phosphatase is a rough index of osteoblastic activity.In osteoporosis (Fig., right) the serum levels of calcium and phosphorus are normal, and the rate of bone résorption is therefore assumed to be normal. The thin trabeculae, then, must be due to an underproduction of sufficient new bone to maintain normal bal¬ ance.Histologically, the osteoblasts and osteoclasts appear qualitatively and quantita¬ tively normal. The level of the serum alka¬ line phosphatase also tends to be normal in osteoporosis. Thus, proof that osteoporosis is due to decreased bone production rather than to increased bone résorption is not avail¬ able histologically or chemically. It none¬ theless appears to be the more logical cause of osteoporosis if it is agreed that résorption is a passive process, while production of bone is a more complicated active process.The slowness with which senile osteo¬ porosis develops suggests that the decrease in osteoblastic activity is exceedingly small relative to continuing bone production, and a decrease in osteoblasts would not be ex¬ pected to be observable by routine histological study. Similarly, a decrease in alkaline phosphatase would not be anticipated.With equilibrium of bone résorption and ...

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The Effects of Stilbestrol on the Retention of Nitrogen, Calcium, Phosphorus, and Potassium in Aged Males with and without Osteoporosis

Cited by 24 publications

References 0 publications

The Action of Chlorotrianisene (Tace) With Androgen on Nitrogen Retention in Elderly People

The Action of Chlorotrianisene (Tace) With Androgen on Nitrogen Retention in Elderly People

Panel Discussion on Osteoporosis†

Senile Osteoporosis

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