The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women With Postmenopausal Osteoporosis

Meunier, Pierre J.; Roux, Christian; Seeman, Ego; Ortolani, S.; Badurski, J; Spector, Tim D.; Cannata, J.; Balogh, Á.; Lemmel, E.-M.; Pors-Nielsen, S.; Rizzoli, René; Genant, Harry K.; Reginster, Jean‐Yves

doi:10.1097/00006254-200407000-00021

Cited by 168 publications

(287 citation statements)

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“…19,20 Indeed, strontium ranelate is a drug used for the treatment of osteoporosis, thanks to its ability to increase bone neoformation and to reduce bone resorption. [21][22][23] Furthermore, strontium has a positive effect on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), [24][25][26][27][28] which are resident at the implant site and are characterized by an intrinsic osteogenic potential. [29][30][31] It has been demonstrated that the use of autologous bone marrow concentrate, obtained by an intra-operative approach, improves bone healing.…”

Section: Introductionmentioning

confidence: 99%

Orthopedic bioactive implants: Hydrogel enrichment of macroporous titanium for the delivery of mesenchymal stem cells and strontium

Lopa¹,

Mercuri

Colombini³

et al. 2013

J Biomedical Materials Res

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Insufficient implant stability is an important determinant in the failure of cementless prostheses. To improve osseointegration, we aim at generating a bioactive implant combining a macroporous titanium (TT) with a biocompatible hydrogel to encapsulate osteo-inductive factors and osteoprogenitor cells. Amidation and cross-linking degree of an amidated carboxymethylcellulose hydrogel (CMCA) were characterized by FT-IR spectrometry and mechanical testing. Bone marrow mesenchymal stem cells (BMSCs) from osteoarthritic patients were cultured on CMCA hydrogels, TT, and TT loaded with CMCA (TT þ CMCA) with an optimized concentration of SrCl 2 to evaluate cell viability and osteo-differentiation. Amidation and cross-linking degree were homogeneous among independent CMCA batches. SrCl 2 at 5 lg/mL significantly improved BMSCs osteo-differentiation increasing calcified matrix (P < 0.01), type I collagen expression (P < 0.05) and alkaline phosphatase activity. TT þ CMCA samples better retained cells into the TT mesh, significantly improving cell seeding efficiency with respect to TT (P < 0.05). BMSCs on TT þ CMCA underwent a more efficient osteo-differentiation with higher alkaline phosphatase (P < 0.05) and calcium levels compared to cells on TT. Based on these in vitro results, we envision the association of TT with strontium-enriched CMCA and BMSCs as a promising strategy to generate bioactive implants promoting bone neoformation at the implant site.

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Section: Introductionmentioning

confidence: 99%

Orthopedic bioactive implants: Hydrogel enrichment of macroporous titanium for the delivery of mesenchymal stem cells and strontium

Lopa¹,

Mercuri

Colombini³

et al. 2013

J Biomedical Materials Res

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“…Так, бисфосфонаты, ак-тивные антирезорбенты, могут быть препаратами выбора в лечении остеопороза при заболеваниях с ускоренной кост-ной резорбцией, в частности, тиреотоксикоза [21]. Однако данные в отношении использования этой группы при СД2 противоречивы: от схожих результатов на увеличение МПК независимо от наличия состояния углеводного обмена, до сниженного ответа на алендронат кортикальной кости (бе-дро, луч) и отсутствия влияния бисфосфонатов на снижение риска переломов [18].…”

Section: оригинальные статьи № 3/2013 остеопороз и остеопатииunclassified

Parameters of Bone Metabolism in Pre-and Postmenopausal Women With Type 2 Diabetes Mellitus in the Rationale for the Choice of Antiosteoporotic Therapy

Ruyatkina¹,

Ломова²,

Ruyatkin³

et al. 2013

Osteopor Bone Dis

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Introduction. Bone health in type 2 diabetes mellitus (T2DM) is discussed for a long time as a known fact for increased risk of fractures. Purpose. To estimate the parameters of bone remodeling in pre-andpostmenopausal women with T2DM. Materials and Methods. In a cross-sectional pilot study which included 80 women: 40 with T2DM and 40 without disturbances of glucose metabolism (K), divided into subgroups of premenopausal (pre) and natural menopause (post) — 20 patients each. Results and conclusions. We found a tendency toward a decrease in bone turnover in patients T2DM, a significant negative relationship with C-peptide and ALP in T2DM, a positive correlation with tartrate — resistant acid phosphatase in the control group, although the levels of C-peptide did not differ in patients with T2DM and in the control group . Identified characteristics of decreased bone remodeling in patients with T2DM pathogenically justify the use of anabolic antiosteoporotic drugs for treatment of osteoporosis in such patients.

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“…A less common adverse event was venous thromboembolism, which was slightly more frequent among strontium ranelate users. [42,43] Examples of non-pharmacological interventions are nutrition, exercise and hip protectors [7].…”

Section: Parathyroid Hormones (Pth)mentioning

confidence: 99%

“…Raloxifene and strontium ranelate are two drugs that have been shown to reduce the risk of fractures in large clinical trials [39,42,43]. Based on the results in these trials, two studies were conducted to estimate the cost-effectiveness of each drug for women in a Swedish setting.…”

Section: Modelling the Cost-effectiveness Of Osteoporosis Treatments mentioning

confidence: 99%

“…The Spinal Osteoporosis Therapeutic Intervention (SOTI) study was a five-year multinational randomised double blind, placebo controlled study, with a main statistical analysis over three years, including 1 649 postmenopausal women aged 50 years or more (mean age=69 years) with at least one radiographically confirmed vertebral fracture and a lumbar spine BMD lower than 0.840g/cm 2 [42]. …”

Section: Clinical Datamentioning

confidence: 99%

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Health economics of osteoporosis

Borgström¹,

Kanis²

2008

Best Practice & Research Clinical Endocrinology & Metab

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The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women With Postmenopausal Osteoporosis

Cited by 168 publications

References 0 publications

Orthopedic bioactive implants: Hydrogel enrichment of macroporous titanium for the delivery of mesenchymal stem cells and strontium

Orthopedic bioactive implants: Hydrogel enrichment of macroporous titanium for the delivery of mesenchymal stem cells and strontium

Parameters of Bone Metabolism in Pre-and Postmenopausal Women With Type 2 Diabetes Mellitus in the Rationale for the Choice of Antiosteoporotic Therapy

Health economics of osteoporosis

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